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Csf2
Gene Detail
Symbol

Name
ID
Csf2
colony stimulating factor 2 (granulocyte-macrophage)
MGI:1339752
Synonyms
Csfgm, Gm-CSf, GMCSF, MGI-IGM
Feature Type
protein coding gene
Genetic Map
Chromosome 11
32.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(59)
Sequence Map
Chr11:54247271-54249667 bp, - strand
From VEGA annotation of GRCm38

  2397 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:600  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: granulocyte-macrophage colony-stimulating factor
Gene Tree: Csf2

Human
homologs
Human Homolog CSF2, colony stimulating factor 2 (granulocyte-macrophage)
NCBI Gene ID 1437
neXtProt AC  NX_P04141
Human Synonyms  GMCSF
Human Chr (Location)  5q31.1; chr5:132073792-132076170 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
 
Homozygotes for targeted null mutations exhibit lung abnormalities with lymphocytic infiltration and accumulation of surfactant lipids. Litter sizes from homozygous breeding pairs are smaller at weaning due to perinatal mortality.
 
Human Diseases Modeled Using Mouse Csf2 (1)    Alleles Annotated to Human Diseases(3)   
Interactions
Csf2 interacts with 63 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (11 records)
Data Summary: Results (45)    Tissues (29)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 39
Nuclease S1 6
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(35) Genomic(13) cDNA(13) Primer pair(8) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000005663 (Evidence)
Ensembl Gene ModelENSMUSG00000018916 (Evidence)
Entrez Gene12981 (Evidence)
UniGene4922
DFCITC1589011
DoTSDT.97391975, DT.40147424
NIA Mouse Gene IndexU032776
Consensus CDS ProjectCCDS24692.1
International Mouse Knockout Project StatusCsf2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005663 VEGA Gene Model | MGI Sequence Detail 2397 C57BL/6J ±  kb
transcript OTTMUST00000012596 VEGA | MGI Sequence Detail 800 Not Applicable 
polypeptide OTTMUSP00000005830 VEGA | MGI Sequence Detail 141 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(4) UniProt(5)
Polymorphisms
All PCR and RFLP(16) : PCR(9) RFLP(7) SNPs within 2kb(67 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012351 Four-helical cytokine, core
InterPro IPR009079 Four-helical cytokine-like, core
InterPro IPR000773 Granulocyte-macrophage colony-stimulating factor
Protein Ontology PR:000005931 granulocyte-macrophage colony-stimulating factor
References
(Earliest) J:7492 Gough NM, et al., Molecular cloning of cDNA encoding a murine haematopoietic growth regulator, granulocyte-macrophage colony stimulating factor. Nature. 1984 Jun 28-Jul 4;309(5971):763-7
(Latest) J:213739 Weber GF, et al., Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis. J Exp Med. 2014 Jun 2;211(6):1243-56
All references(301)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-2187, MGI:88531

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory