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Csf2
Gene Detail
 Symbol
Name
ID
Csf2
colony stimulating factor 2 (granulocyte-macrophage)
MGI:1339752
Synonyms Csfgm, Gm-CSf, GMCSF, MGI-IGM
Feature Type protein coding gene
Genetic Map
Chromosome 11
32.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(59)
Sequence Map
Chr11:54247271-54249667 bp, - strand
From VEGA annotation of GRCm38

  2397 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:600  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Protein SuperFamily: granulocyte-macrophage colony-stimulating factor
Gene Tree: Csf2

Human
homologs
Human Homolog CSF2, colony stimulating factor 2 (granulocyte-macrophage)
NCBI Gene ID 1437
neXtProt AC  NX_P04141
Human Synonyms  GMCSF
Human Chr (Location)  5q31.1; chr5:132073792-132076170 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
 
Homozygotes for targeted null mutations exhibit lung abnormalities with lymphocytic infiltration and accumulation of surfactant lipids. Litter sizes from homozygous breeding pairs are smaller at weaning due to perinatal mortality.
 
Human Diseases Modeled Using Mouse Csf2 (1)    Alleles Annotated to Human Diseases(3)   
Interactions
Csf2 interacts with 63 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process dendritic cell differentiation, embryonic placenta development, ...
Component extracellular region, extracellular space
Function cytokine activity, granulocyte macrophage colony-stimulating factor receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (45)    Tissues (29)   
Theiler Stages: 1, 2, 3, 4, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RT-PCR 39
Nuclease S1 6
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(35) Genomic(13) cDNA(13) Primer pair(8) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000005663 (Evidence)
Ensembl Gene ModelENSMUSG00000018916 (Evidence)
Entrez Gene12981 (Evidence)
UniGene4922
DFCITC1589011
DoTSDT.40147424, DT.97391975
NIA Mouse Gene IndexU032776
Consensus CDS ProjectCCDS24692.1
International Mouse Knockout Project StatusCsf2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005663 VEGA Gene Model | MGI Sequence Detail 2397 C57BL/6J ±  kb
transcript OTTMUST00000012596 VEGA | MGI Sequence Detail 800 Not Applicable 
polypeptide OTTMUSP00000005830 VEGA | MGI Sequence Detail 141 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(4) UniProt(3)
Polymorphisms All PCR and RFLP(16) : PCR(9) RFLP(7) SNPs within 2kb(67 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012351 Four-helical cytokine, core
InterPro IPR009079 Four-helical cytokine-like, core
InterPro IPR000773 Granulocyte-macrophage colony-stimulating factor
Protein Ontology PR:000005931 granulocyte-macrophage colony-stimulating factor
References (Earliest) J:7492 Gough NM, et al., Molecular cloning of cDNA encoding a murine haematopoietic growth regulator, granulocyte-macrophage colony stimulating factor. Nature. 1984 Jun 28-Jul 4;309(5971):763-7
(Latest) J:209938 Ko HJ, et al., GM-CSF-responsive monocyte-derived dendritic cells are pivotal in Th17 pathogenesis. J Immunol. 2014 Mar 1;192(5):2202-9
All references(300)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-2187, MGI:88531

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory