Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CLDN19
  • Mouse genes Cldn19
  • Rat genes Cldn19
  • Zfish genes cldn19
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cldn19

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	Cldn19	IPI	UniProtKB:P01558	Mouse	MGI:MGI:5917869|PMID:25678664
Cellular Component	GO:0043296	apical junction complex	CLDN19	IDA		Human	PMID:16427635
Cellular Component	GO:0043296	apical junction complex	CLDN19	IMP		Human	PMID:27593915
Cellular Component	GO:0016323	basolateral plasma membrane	CLDN19	IDA		Human	PMID:16427635
Cellular Component	GO:0005923	bicellular tight junction	CLDN19	IDA		Human	PMID:16427635
Cellular Component	GO:0005923	bicellular tight junction	Cldn19	IDA		Mouse	PMID:27583434
Cellular Component	GO:0005923	bicellular tight junction	Cldn19	IDA		Mouse	PMID:15883201
Cellular Component	GO:0030054	cell junction	Cldn19	IDA		Mouse	PMID:16427635
Cellular Component	GO:0005737	cytoplasm	Cldn19	IDA		Mouse	PMID:16427635
Cellular Component	GO:0005634	nucleus	Cldn19	IDA		Mouse	PMID:16427635
Cellular Component	GO:0048471	perinuclear region of cytoplasm	CLDN19	IMP		Human	PMID:27593915
Cellular Component	GO:0005886	plasma membrane	CLDN19	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	Cldn19	IDA		Mouse	MGI:MGI:5917869|PMID:25678664
Biological Process	GO:0031532	actin cytoskeleton reorganization	CLDN19	IMP		Human	PMID:27593915
Biological Process	GO:0043297	apical junction assembly	Cldn19	IMP	MGI:MGI:3583804	Mouse	PMID:15883201
Biological Process	GO:0030336	negative regulation of cell migration	CLDN19	IMP		Human	PMID:27593915
Biological Process	GO:0008285	negative regulation of cell population proliferation	CLDN19	IMP		Human	PMID:27593915
Biological Process	GO:0010629	negative regulation of gene expression	CLDN19	IMP		Human	PMID:27593915
Biological Process	GO:0061045	negative regulation of wound healing	CLDN19	IMP		Human	PMID:27593915
Biological Process	GO:0019227	neuronal action potential propagation	Cldn19	IMP	MGI:MGI:3583804	Mouse	PMID:15883201
Biological Process	GO:1901890	positive regulation of cell junction assembly	CLDN19	IMP		Human	PMID:27593915
Biological Process	GO:0010628	positive regulation of gene expression	CLDN19	IMP		Human	PMID:27593915
Biological Process	GO:0001934	positive regulation of protein phosphorylation	CLDN19	IMP		Human	PMID:27593915
Biological Process	GO:0150111	regulation of transepithelial transport	CLDN19	IMP		Human	PMID:27593915
Biological Process	GO:0120193	tight junction organization	Cldn19	IMP	MGI:MGI:3583804	Mouse	PMID:15883201

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern