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Cldn19
Gene Detail
 Symbol
Name
ID
Cldn19
claudin 19
MGI:3033992
Feature Type protein coding gene
Genetic Map
Chromosome 4
55.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:119255414-119262438 bp, + strand
From VEGA annotation of GRCm38

  7025 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:17528  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Cldn19

Human
homologs
Human Homolog CLDN19, claudin 19
NCBI Gene ID 149461
neXtProt AC  NX_Q8N6F1
Human Synonyms  HOMG5
Human Chr (Location)  1p34.2; chr1:42733093-42740254 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CLDN19
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
 
Mice homozygous for a knock-out allele exhibit a peripheral neuropathy associated with significant behavioral abnormalities, a complete lack of tight junctions from myelinated Schwann cells, and abnormal nerve conduction parameters of peripheral myelinated fibers.
 
Phenotype Images(1)
Interactions
Cldn19 interacts with 272 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process apical junction assembly, neuronal action potential propagation
Component apical junction complex, basolateral plasma membrane, ...
Function structural molecule activity
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (31)    Tissues (30)    Images (3)
Theiler Stages: 23, 26
Assay TypeResults
RNA in situ 31
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) cDNA(7)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000009224 (Evidence)
Ensembl Gene ModelENSMUSG00000066058 (Evidence)
Entrez Gene242653 (Evidence)
UniGene130701
DFCITC1588392, TC1592321
DoTSDT.40168353, DT.91356719
NIA Mouse Gene IndexU004737
Consensus CDS ProjectCCDS18577.1, CCDS18578.1
International Mouse Knockout Project StatusCldn19
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009224 VEGA Gene Model | MGI Sequence Detail 7025 C57BL/6J ±  kb
transcript OTTMUST00000020878 VEGA | MGI Sequence Detail 924 Not Applicable 
polypeptide OTTMUSP00000009569 VEGA | MGI Sequence Detail 224 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(98 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006187 Claudin
InterPro IPR017974 Claudin, conserved site
InterPro IPR004031 PMP-22/EMP/MP20/Claudin
Protein Ontology PR:000005546 claudin-19
References (Earliest) J:95370 Luk JM, et al., Sp1 site is crucial for the mouse claudin-19 gene expression in the kidney cells. FEBS Lett. 2004 Dec 17;578(3):251-6
(Latest) J:181271 Westmoreland JJ, et al., Dynamic distribution of claudin proteins in pancreatic epithelia undergoing morphogenesis or neoplastic transformation. Dev Dyn. 2012 Mar;241(3):583-94
All references(33)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory