Cldn19
Gene Detail

Symbol Name ID

Cldn19 claudin 19 MGI:3033992

Feature Type

protein coding gene

Genetic Map

Chromosome 4

55.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr4:119255414-119262438 bp, + strand From VEGA annotation of GRCm38   7025 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:17528  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Cldn19

Human homologs

Human Homolog		CLDN19, claudin 19
NCBI Gene ID		149461
neXtProt AC		NX_Q8N6F1
Human Synonyms		HOMG5
Human Chr (Location)		1p34.2; chr1:43198764-43205925 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CLDN19

Alleles and phenotypes

All alleles(5) : Targeted(4) Gene trapped(1)
 

Mice homozygous for a knock-out allele exhibit a peripheral neuropathy associated with significant behavioral abnormalities, a complete lack of tight junctions from myelinated Schwann cells, and abnormal nerve conduction parameters of peripheral myelinated fibers.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	apical junction assembly, neuronal action potential propagation
Component	apical junction complex, basolateral plasma membrane, ...
Function	structural molecule activity

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (4)    Tissues (3)    Images (2)
Theiler Stages: 23

Assay Type	Results
RNA in situ	4

cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(7) cDNA(7)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000009224 (Evidence)
Ensembl Gene Model	ENSMUSG00000066058 (Evidence)
Entrez Gene	242653 (Evidence)
UniGene	130701
DFCI	TC1588392, TC1592321
DoTS	DT.40168353, DT.91356719
NIA Mouse Gene Index	U004737
Consensus CDS Project	CCDS18577.1, CCDS18578.1
International Mouse Knockout Project Status	Cldn19

Sequences

Length	Strain/Species
genomic	OTTMUSG00000009224	VEGA Gene Model | MGI Sequence Detail	7025	C57BL/6J
transcript	OTTMUST00000020878	VEGA | MGI Sequence Detail	924	Not Applicable
polypeptide	OTTMUSP00000009569	VEGA | MGI Sequence Detail	224	Not Applicable

All sequences(28) RefSeq(4) UniProt(2)

Polymorphisms

SNPs(77 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006187	Claudin
InterPro	IPR017974	Claudin, conserved site
InterPro	IPR004031	PMP-22/EMP/MP20/Claudin
Protein Ontology	PR:000005546	claudin-19

References

(Earliest) J:95370 Luk JM, et al., Sp1 site is crucial for the mouse claudin-19 gene expression in the kidney cells. FEBS Lett. 2004 Dec 17;578(3):251-6
(Latest) J:181271 Westmoreland JJ, et al., Dynamic distribution of claudin proteins in pancreatic epithelia undergoing morphogenesis or neoplastic transformation. Dev Dyn. 2012 Mar;241(3):583-94
All references(31)