About   Help   FAQ
Cldn19
Gene Detail
Symbol

Name
ID
Cldn19
claudin 19
MGI:3033992
Feature Type
protein coding gene
Genetic Map
Chromosome 4
55.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:119255414-119262438 bp, + strand
From VEGA annotation of GRCm38

  7025 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:17528  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CLDN19
Gene Tree: Cldn19

Human
homologs
CLDN19, claudin 19
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 149461
neXtProt AC: NX_Q8N6F1

Human Synonyms: HOMG5

Human Chr (Location): 1p34.2; chr1:42733093-42740254 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CLDN19

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Genomic Mutations involving Cldn19 (1)
 
Mice homozygous for a knock-out allele exhibit a peripheral neuropathy associated with significant behavioral abnormalities, a complete lack of tight junctions from myelinated Schwann cells, and abnormal nerve conduction parameters of peripheral myelinated fibers.
 
Phenotype Images(1)
Interactions
Cldn19 interacts with 271 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process apical junction assembly, neuronal action potential propagation
Component apical junction complex, basolateral plasma membrane, ...
Function structural molecule activity
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (31)    Tissues (30)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 31
cDNA source data(7)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cldn19    NEW 
Molecular
reagents
All nucleic(7) cDNA(7)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000009224 (Evidence)
Ensembl Gene Model ENSMUSG00000066058 (Evidence)
Entrez Gene 242653 (Evidence)
UniGene 130701
DFCI TC1588392, TC1592321
DoTS DT.40168353, DT.91356719
NIA Mouse Gene Index U004737
PDB 3X29
Consensus CDS Project CCDS18577.1, CCDS18578.1
International Mouse Phenotyping Consortium Status Cldn19
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009224 VEGA Gene Model | MGI Sequence Detail 7025 C57BL/6J ±  kb
transcript OTTMUST00000020878 VEGA | MGI Sequence Detail 924 Not Applicable 
polypeptide OTTMUSP00000009569 VEGA | MGI Sequence Detail 224 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(98 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006187 Claudin
InterPro IPR017974 Claudin, conserved site
InterPro IPR004031 PMP-22/EMP/MP20/Claudin
Protein Ontology PR:000005546 claudin-19
References
(Earliest) J:95370 Luk JM, et al., Sp1 site is crucial for the mouse claudin-19 gene expression in the kidney cells. FEBS Lett. 2004 Dec 17;578(3):251-6
(Latest) J:181271 Westmoreland JJ, et al., Dynamic distribution of claudin proteins in pancreatic epithelia undergoing morphogenesis or neoplastic transformation. Dev Dyn. 2012 Mar;241(3):583-94
All references(32)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/18/2015
MGI 6.0
The Jackson Laboratory