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Cldn19 Gene Detail
Summary
  • Symbol
    Cldn19
  • Name
    claudin 19
  • Feature Type
    protein coding gene
  • IDs
    MGI:3033992
    NCBI Gene: 242653
  • Gene Overview
    MyGene.info: CLDN19
Location & Maps
more
  • Sequence Map
    Chr4:119255414-119262438 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7025 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 55.34 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    CLDN19, claudin 19
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CLDN19, claudin 19
    Orthology source: HomoloGene
  • Synonyms
    HOMG5
  • Links
    NCBI Gene ID: 149461
    neXtProt AC: NX_Q8N6F1

  • Chr Location
    1p34.2; chr1:42733093-42740254 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human CLDN19 associations

Human Disease Mouse Models
       Hypomagnesemia 5, Renal, with Ocular Involvement; HOMG5   OMIM: 248190
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    2
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    6
  • Genomic Mutations
    4 involving Cldn19
Mice homozygous for a knock-out allele exhibit a peripheral neuropathy associated with significant behavioral abnormalities, a complete lack of tight junctions from myelinated Schwann cells, and abnormal nerve conduction parameters of peripheral myelinated fibers.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009224 VEGA Gene Model | MGI Sequence Detail 7025 C57BL/6J ±  kb
transcript OTTMUST00000020878 VEGA | MGI Sequence Detail 924 Not Applicable  
polypeptide OTTMUSP00000009569 VEGA | MGI Sequence Detail 224 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    98 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    cDNA 7

    Microarray probesets 2
References
more
  • Summaries
    All 30
    Developmental Gene Expression 5
    Gene Ontology 4
    Phenotypes 13
  • Earliest
    J:95370 Luk JM, et al., Sp1 site is crucial for the mouse claudin-19 gene expression in the kidney cells. FEBS Lett. 2004 Dec 17;578(3):251-6
  • Latest
    J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory