Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Ccnd2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes CCND2
- Mouse genes Ccnd2
- Rat genes Ccnd2
- Zfish genes ccnd2a,ccnd2b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ccnd2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity	CCND2	IDA		Human	PMID:18827403
Molecular Function	GO:0005515	protein binding	CCND2	IPI	UniProtKB:P11802	Human	PMID:11896535
Molecular Function	GO:0005515	protein binding	CCND2	IPI	UniProtKB:P38936	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	CCND2	IPI	UniProtKB:P46527	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	CCND2	IPI	UniProtKB:P38936	Human	PMID:16765349
Molecular Function	GO:0005515	protein binding	CCND2	IPI	UniProtKB:Q00535	Human	PMID:23455922
Molecular Function	GO:0005515	protein binding	CCND2	IPI	UniProtKB:Q00535	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	CCND2	IPI	UniProtKB:P38936	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	CCND2	IPI	UniProtKB:P38936	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CCND2	IPI	UniProtKB:Q00535	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CCND2	IPI	UniProtKB:P11802	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	CCND2	IPI	UniProtKB:P46527	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	CCND2	IPI	UniProtKB:Q00535	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	CCND2	IPI	UniProtKB:P11802	Human	PMID:27107012
Molecular Function	GO:0005515	protein binding	CCND2	IPI	UniProtKB:P38936	Human	PMID:27107012
Molecular Function	GO:0005515	protein binding	CCND2	IPI	UniProtKB:Q00535	Human	PMID:27107012
Molecular Function	GO:0005515	protein binding	CCND2	IPI	UniProtKB:P11802	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CCND2	IPI	UniProtKB:P38936	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CCND2	IPI	UniProtKB:P46527	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CCND2	IPI	UniProtKB:Q00535	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CCND2	IPI	UniProtKB:P11802	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	CCND2	IPI	UniProtKB:P38936	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	CCND2	IPI	UniProtKB:P11802	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CCND2	IPI	UniProtKB:P38936	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CCND2	IPI	UniProtKB:Q00535	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CCND2	IPI	UniProtKB:Q00535	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	Ccnd2	IPI	PR:P46414	Mouse	PMID:8033213
Molecular Function	GO:0005515	protein binding	Ccnd2	IPI	PR:Q64261	Mouse	PMID:21652635
Molecular Function	GO:0019901	protein kinase binding	CCND2	IPI	UniProtKB:Q00534	Human	PMID:8114739
Molecular Function	GO:0019901	protein kinase binding	Ccnd2	IPI	RGD:621120	Rat	PMID:15809057\|RGD:1582338
Molecular Function	GO:0019901	protein kinase binding	Ccnd2	IPI	RGD:621121	Rat	PMID:15809057\|RGD:1582338
Cellular Component	GO:0000785	chromatin	CCND2	IDA		Human	PMID:18827403
Cellular Component	GO:0097129	cyclin D2-CDK4 complex	CCND2	IPI		Human	PMID:11896535
Cellular Component	GO:0097129	cyclin D2-CDK4 complex	Ccnd2	IDA		Mouse	PMID:7739547
Cellular Component	GO:0097129	cyclin D2-CDK4 complex	Ccnd2	IDA		Mouse	PMID:8543804
Cellular Component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	CCND2	IDA		Human	PMID:18827403
Cellular Component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	CCND2	IDA		Human	PMID:8114739
Cellular Component	GO:0005737	cytoplasm	Ccnd2	IDA		Mouse	PMID:26657864
Cellular Component	GO:0005829	cytosol	CCND2	IDA		Human	PMID:18827403
Cellular Component	GO:0031965	nuclear membrane	CCND2	IDA		Human	PMID:18827403
Cellular Component	GO:0005730	nucleolus	CCND2	IDA		Human	PMID:18827403
Cellular Component	GO:0005654	nucleoplasm	CCND2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	CCND2	IDA		Human	PMID:18827403
Cellular Component	GO:0005634	nucleus	Ccnd2	IDA		Mouse	PMID:12801993
Cellular Component	GO:0005634	nucleus	Ccnd2	IDA		Mouse	PMID:23109711
Cellular Component	GO:0005634	nucleus	Ccnd2	IDA		Mouse	PMID:26657864
Cellular Component	GO:0005634	nucleus	Ccnd2	IDA		Rat	PMID:12387751\|RGD:151660358
Biological Process	GO:0008344	adult locomotory behavior	Ccnd2	IMP	MGI:MGI:2180642	Mouse	PMID:23714078
Biological Process	GO:0071549	cellular response to dexamethasone stimulus	Ccnd2	IEP		Rat	PMID:27302109\|RGD:151660350
Biological Process	GO:0071372	cellular response to follicle-stimulating hormone stimulus	Ccnd2	IEP		Rat	PMID:15613482\|RGD:151660357
Biological Process	GO:0071378	cellular response to growth hormone stimulus	Ccnd2	IEP		Rat	PMID:12586844\|RGD:151660347
Biological Process	GO:0032869	cellular response to insulin stimulus	Ccnd2	IEP		Rat	PMID:16210359\|RGD:1582339
Biological Process	GO:0071394	cellular response to testosterone stimulus	Ccnd2	IEP		Rat	PMID:23028064\|RGD:151664601
Biological Process	GO:0071481	cellular response to X-ray	Ccnd2	IMP	MGI:MGI:2180642	Mouse	PMID:23714078
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	CCND2	IDA		Human	PMID:18827403
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	Ccnd2	IMP		Rat	PMID:12130558\|RGD:625716
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	Ccnd2	IEP		Rat	PMID:7926809\|RGD:724624
Biological Process	GO:0001889	liver development	Ccnd2	IEP		Rat	PMID:15809057\|RGD:1582338
Biological Process	GO:0007616	long-term memory	Ccnd2	IMP	MGI:MGI:2180642	Mouse	PMID:23714078
Biological Process	GO:0043066	negative regulation of apoptotic process	CCND2	IMP		Human	PMID:24130168
Biological Process	GO:2000726	negative regulation of cardiac muscle cell differentiation	Ccnd2	IDA		Rat	PMID:27302109\|RGD:151660350
Biological Process	GO:0001541	ovarian follicle development	Ccnd2	IEP		Rat	PMID:17971845\|RGD:2289161
Biological Process	GO:0060045	positive regulation of cardiac muscle cell proliferation	Ccnd2	IDA		Rat	PMID:27302109\|RGD:151660350
Biological Process	GO:0008284	positive regulation of cell population proliferation	CCND2	IMP		Human	PMID:24130168
Biological Process	GO:0008284	positive regulation of cell population proliferation	Ccnd2	IMP		Rat	PMID:12130558\|RGD:625716
Biological Process	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	CCND2	IDA		Human	PMID:8114739
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	Ccnd2	IMP		Rat	PMID:7811475\|RGD:2289224
Biological Process	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	CCND2	IMP		Human	PMID:24130168
Biological Process	GO:0001934	positive regulation of protein phosphorylation	CCND2	IDA		Human	PMID:8114739
Biological Process	GO:0051726	regulation of cell cycle	Ccnd2	IMP	MGI:MGI:2180642	Mouse	PMID:11809706
Biological Process	GO:0045664	regulation of neuron differentiation	Ccnd2	IEP		Rat	PMID:8028782\|RGD:2289187
Biological Process	GO:0051591	response to cAMP	Ccnd2	IEP		Rat	PMID:9658398\|RGD:2289186
Biological Process	GO:0032355	response to estradiol	Ccnd2	IEP		Rat	PMID:12437973\|RGD:2289184
Biological Process	GO:0043627	response to estrogen	Ccnd2	IEP		Rat	PMID:9658398\|RGD:2289186
Biological Process	GO:0045471	response to ethanol	Ccnd2	IEP		Rat	PMID:12480138\|RGD:2289183
Biological Process	GO:0032354	response to follicle-stimulating hormone	Ccnd2	IEP		Rat	PMID:9658398\|RGD:2289186
Biological Process	GO:0044752	response to human chorionic gonadotropin	Ccnd2	IEP		Rat	PMID:9658398\|RGD:2289186
Biological Process	GO:0014070	response to organic cyclic compound	Ccnd2	IEP		Rat	PMID:7811475\|RGD:2289224
Biological Process	GO:0043434	response to peptide hormone	Ccnd2	IEP		Rat	PMID:14691013\|RGD:2289182
Biological Process	GO:0033574	response to testosterone	Ccnd2	IEP		Rat	PMID:15659706\|RGD:2289162
Biological Process	GO:0007283	spermatogenesis	Ccnd2	IEP		Rat	PMID:15659706\|RGD:2289162

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.