Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes BACE2
  • Mouse genes Bace2
  • Rat genes Bace2
  • Zfish genes bace2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Bace2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004190	aspartic-type endopeptidase activity	BACE2	IDA		Human	PMID:10591213
Molecular Function	GO:0008233	peptidase activity	Bace2	IGI	MGI:MGI:109548	Mouse	PMID:31838721
Molecular Function	GO:0008233	peptidase activity	Bace2	IMP		Mouse	PMID:31838721
Molecular Function	GO:0005515	protein binding	BACE2	IPI	UniProtKB:P10997	Human	PMID:26840340
Molecular Function	GO:0005515	protein binding	BACE2	IPI	UniProtKB:O75558	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BACE2	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BACE2	IPI	UniProtKB:P06753-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BACE2	IPI	UniProtKB:P08727	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BACE2	IPI	UniProtKB:P42679	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BACE2	IPI	UniProtKB:P57682	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BACE2	IPI	UniProtKB:Q13510-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BACE2	IPI	UniProtKB:Q14847-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BACE2	IPI	UniProtKB:Q6DKI2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BACE2	IPI	UniProtKB:Q86XM0	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BACE2	IPI	UniProtKB:Q8IUR5-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BACE2	IPI	UniProtKB:Q8TDR4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BACE2	IPI	UniProtKB:Q8WZ73-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BACE2	IPI	UniProtKB:Q92615	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BACE2	IPI	UniProtKB:Q9BSD3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BACE2	IPI	UniProtKB:Q9BXU0	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BACE2	IPI	UniProtKB:Q9BY12-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BACE2	IPI	UniProtKB:Q9NP61	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BACE2	IPI	UniProtKB:Q9Y6W6	Human	PMID:32814053
Cellular Component	GO:0005737	cytoplasm	Bace2	IDA		Rat	PMID:19117266|RGD:13782168
Cellular Component	GO:0031045	dense core granule	Bace2	IDA		Rat	PMID:19117266|RGD:13782168
Cellular Component	GO:0005794	Golgi apparatus	BACE2	IDA		Human	PMID:11423558
Cellular Component	GO:0033162	melanosome membrane	BACE2	IDA		Human	PMID:23754390
Cellular Component	GO:0005886	plasma membrane	BACE2	IDA		Human	PMID:21907142
Cellular Component	GO:0005886	plasma membrane	Bace2	IDA		Mouse	MGI:MGI:5292404|PMID:21907142
Biological Process	GO:0048143	astrocyte activation	Bace2	IEP		Rat	PMID:21073551|RGD:13782176
Biological Process	GO:0048484	enteric nervous system development	bace2	IMP	ZFIN:ZDB-MRPHLNO-220426-2	Zfish	PMID:34136475
Biological Process	GO:0042593	glucose homeostasis	BACE2	IMP		Human	PMID:21907142
Biological Process	GO:0097324	melanocyte migration	bace2	IMP		Zfish	PMID:23406323
Biological Process	GO:0032438	melanosome organization	BACE2	IMP		Human	PMID:23754390
Biological Process	GO:0032438	melanosome organization	Bace2	IMP		Mouse	MGI:MGI:5495053|PMID:23754390
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	BACE2	IDA		Human	PMID:10591213
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	BACE2	IMP		Human	PMID:21907142
Biological Process	GO:0042985	negative regulation of amyloid precursor protein biosynthetic process	BACE2	IMP		Human	PMID:12801932
Biological Process	GO:0016485	protein processing	BACE2	IDA		Human	PMID:23754390
Biological Process	GO:0140448	signaling receptor ligand precursor processing	Bace2	IGI	MGI:MGI:109548	Mouse	PMID:31838721
Biological Process	GO:0140448	signaling receptor ligand precursor processing	Bace2	IMP		Mouse	PMID:31838721

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern