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Bace2
Gene Detail
Symbol

Name
ID
Bace2
beta-site APP-cleaving enzyme 2
MGI:1860440
Synonyms
1110059C24Rik, ALP56, ARP1, ASP21, BAE2, CDA13, CEAP1
Feature Type
protein coding gene
Genetic Map
Chromosome 16
57.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:97356728-97439012 bp, + strand
From NCBI annotation of GRCm38

  82285 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22696  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: BACE2
Protein SuperFamily: memapsin
Gene Tree: Bace2

Human
homologs
BACE2, beta-site APP-cleaving enzyme 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 25825
neXtProt AC: NX_Q9Y5Z0

Human Synonyms: AEPLC, ALP56, ASP1, ASP21, BAE2, CDA13, CEAP1, DRAP

Human Chr (Location): 21q22.3; chr21:41167801-41282534 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Genomic Mutations involving Bace2 (2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation of this gene results in impaired APP processing by neurons and glia.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Bace2 interacts with 287 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process beta-amyloid metabolic process, membrane protein ectodomain proteolysis, ...
Component endoplasmic reticulum, endosome, ...
Function aspartic-type endopeptidase activity, beta-amyloid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (237)    Tissues (152)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 210
RT-PCR 27
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase bace2    NEW 
Molecular
reagents
All nucleic(14) cDNA(12) Primer pair(2)
Microarray probesets(8)
Other database
links
Ensembl Gene Model ENSMUSG00000040605 (Evidence)
Entrez Gene 56175 (Evidence)
DFCI TC1576248, TC1744223
DoTS DT.110734587, DT.40141912, DT.94295732
NIA Mouse Gene Index U017427
EC 3.4.23.45
Consensus CDS Project CCDS28359.1
International Mouse Phenotyping Consortium Status Bace2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 56175 NCBI Gene Model | MGI Sequence Detail 82285 C57BL/6J ±  kb
transcript NM_019517 RefSeq | MGI Sequence Detail 3736 C57BL/6 
polypeptide Q9JL18 UniProt | EBI | MGI Sequence Detail 514 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(444 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021109 Aspartic peptidase
InterPro IPR001461 Peptidase A1
InterPro IPR009121 Peptidase A1, beta-site APP cleaving enzyme 2, BACE 2
InterPro IPR009119 Peptidase A1, beta-site APP cleaving enzyme, BACE
InterPro IPR001969 Peptidase aspartic, active site
Protein Ontology PR:000004616 beta-secretase 2
Graphical View of Protein Domain Structure
References
(Earliest) J:65205 Marcinkiewicz M, et al., Coordinated expression of beta-amyloid precursor protein and the putative beta-secretase BACE and alpha-secretase ADAM10 in mouse and human brain. J Neurochem. 2000 Nov;75(5):2133-43
(Latest) J:197977 Rochin L, et al., BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells. Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10658-63
All references(45)
Other
accession IDs
MGI:1916053, MGI:2146505

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory