About   Help   FAQ
Bace2
Gene Detail
 Symbol
Name
ID
Bace2
beta-site APP-cleaving enzyme 2
MGI:1860440
Synonyms 1110059C24Rik, ALP56, ARP1, ASP21, BAE2, CDA13, CEAP1
Feature Type protein coding gene
Genetic Map
Chromosome 16
57.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:97356728-97439012 bp, + strand
From NCBI annotation of GRCm38

  82285 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22696  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: memapsin
Gene Tree: Bace2

Human
homologs
Human Homolog BACE2, beta-site APP-cleaving enzyme 2
NCBI Gene ID 25825
neXtProt AC  NX_Q9Y5Z0
Human Synonyms  AEPLC, ALP56, ASP1, ASP21, BAE2, CEAP1, DRAP
Human Chr (Location)  21q22.3; chr21:41167801-41282534 (+)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in impaired APP processing by neurons and glia.
 
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process membrane protein ectodomain proteolysis, negative regulation of amyloid precursor protein biosynthetic process, ...
Component endoplasmic reticulum, endosome, ...
Function aspartic-type endopeptidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (239)    Tissues (154)    Images (22)
Theiler Stages: 13, 15, 17, 20, 22, 23, 26, 27, 28
Assay TypeResults
RNA in situ 212
RT-PCR 27
cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(14) cDNA(12) Primer pair(2)
Microarray probesets(8)
Other database
links
Ensembl Gene ModelENSMUSG00000040605 (Evidence)
Entrez Gene56175 (Evidence)
DFCITC1576248, TC1744223
DoTSDT.110734587, DT.40141912, DT.94295732
NIA Mouse Gene IndexU017427
EC3.4.23.45
Consensus CDS ProjectCCDS28359.1
International Mouse Knockout Project StatusBace2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 56175 NCBI Gene Model | MGI Sequence Detail 82285 C57BL/6J ±  kb
transcript NM_019517 RefSeq | MGI Sequence Detail 3736 C57BL/6 
polypeptide Q9JL18 UniProt | EBI | MGI Sequence Detail 514 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(444 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021109 Aspartic peptidase
InterPro IPR001461 Peptidase A1
InterPro IPR009121 Peptidase A1, beta-site APP cleaving enzyme 2, BACE 2
InterPro IPR009119 Peptidase A1, beta-site APP cleaving enzyme, BACE
InterPro IPR001969 Peptidase aspartic, active site
Protein Ontology PR:000004616 beta-secretase 2
Graphical View of Protein Domain Structure
References (Earliest) J:65205 Marcinkiewicz M, et al., Coordinated expression of beta-amyloid precursor protein and the putative beta-secretase BACE and alpha-secretase ADAM10 in mouse and human brain. J Neurochem. 2000 Nov;75(5):2133-43
(Latest) J:197977 Rochin L, et al., BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells. Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10658-63
All references(45)
Other
accession IDs
MGI:1916053, MGI:2146505

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory