Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes B2M
  • Mouse genes B2m
  • Rat genes B2m
  • Zfish genes b2m,b2ml
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set B2m

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	B2M	IPI	UniProtKB:P61769	Human	PMID:17108084
Molecular Function	GO:0042802	identical protein binding	B2M	IPI	UniProtKB:P61769	Human	PMID:18579777
Molecular Function	GO:0042802	identical protein binding	B2M	IPI	UniProtKB:P61769	Human	PMID:19172750
Molecular Function	GO:0042802	identical protein binding	B2M	IPI	UniProtKB:P61769	Human	PMID:19564620
Molecular Function	GO:0042802	identical protein binding	B2M	IPI	UniProtKB:P61769	Human	PMID:20826442
Molecular Function	GO:0042802	identical protein binding	B2M	IPI	UniProtKB:P61769	Human	PMID:21131979
Molecular Function	GO:0042802	identical protein binding	B2M	IPI	UniProtKB:P61769	Human	PMID:21220305
Molecular Function	GO:0042802	identical protein binding	B2M	IPI	UniProtKB:P61769	Human	PMID:21569201
Molecular Function	GO:0042802	identical protein binding	B2M	IPI	UniProtKB:P61769	Human	PMID:22289140
Molecular Function	GO:0042802	identical protein binding	B2M	IPI	UniProtKB:P61769	Human	PMID:22575645
Molecular Function	GO:0005515	protein binding	B2M	IPI	UniProtKB:P29016	Human	PMID:12118248
Molecular Function	GO:0005515	protein binding	B2M	IPI	UniProtKB:P06126	Human	PMID:12833155
Molecular Function	GO:0005515	protein binding	B2M	IPI	UniProtKB:P29016	Human	PMID:14764708
Molecular Function	GO:0005515	protein binding	B2M	IPI	UniProtKB:P06126	Human	PMID:15723809
Molecular Function	GO:0005515	protein binding	B2M	IPI	UniProtKB:Q30201	Human	PMID:15965644
Molecular Function	GO:0005515	protein binding	B2M	IPI	UniProtKB:Q03518	Human	PMID:18802093
Molecular Function	GO:0005515	protein binding	B2M	IPI	UniProtKB:Q9BZW8	Human	PMID:20164429
Molecular Function	GO:0005515	protein binding	B2M	IPI	UniProtKB:Q30201	Human	PMID:20618438
Molecular Function	GO:0005515	protein binding	B2M	IPI	UniProtKB:Q95460-1	Human	PMID:23051753
Molecular Function	GO:0005515	protein binding	B2M	IPI	UniProtKB:P12004	Human	PMID:23527218
Molecular Function	GO:0005515	protein binding	B2M	IPI	UniProtKB:P12004	Human	PMID:26030842
Molecular Function	GO:0005515	protein binding	B2M	IPI	UniProtKB:Q95460	Human	PMID:27043408
Molecular Function	GO:0005515	protein binding	B2M	IPI	UniProtKB:P29016	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	B2M	IPI	UniProtKB:Q9Y3Y4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	B2M	IPI	UniProtKB:P13747	Human	PMID:9427624
Molecular Function	GO:0005515	protein binding	B2M	IPI	UniProtKB:Q30201	Human	PMID:9465039
Molecular Function	GO:0005515	protein binding	B2M	IPI	UniProtKB:Q30201	Human	PMID:9546397
Molecular Function	GO:0005515	protein binding	B2M	IPI	UniProtKB:Q30201	Human	PMID:9990067
Molecular Function	GO:0005515	protein binding	B2m	IPI	PR:Q8HWE7	Mouse	PMID:16920948
Molecular Function	GO:0005515	protein binding	B2m	IPI	PR:P14427	Mouse	PMID:14735325
Molecular Function	GO:0005515	protein binding	B2m	IPI	PR:Q8HWE5	Mouse	PMID:16920948
Molecular Function	GO:0042803	protein homodimerization activity	B2M	IDA		Human	PMID:28468825
Cellular Component	GO:0005829	cytosol	B2M	IDA		Human	GO_REF:0000052
Cellular Component	GO:0009897	external side of plasma membrane	B2m	IDA		Mouse	PMID:1538753
Cellular Component	GO:0070062	extracellular exosome	B2M	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	B2M	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	B2M	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	B2M	HDA		Human	PMID:16502470
Cellular Component	GO:0005615	extracellular space	B2M	HDA		Human	PMID:22664934
Cellular Component	GO:0005615	extracellular space	B2m	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Cellular Component	GO:0005615	extracellular space	B2m	IDA		Rat	PMID:3516141|RGD:1599431
Cellular Component	GO:0005925	focal adhesion	B2M	HDA		Human	PMID:21423176
Cellular Component	GO:0005794	Golgi apparatus	B2M	IDA		Human	GO_REF:0000052
Cellular Component	GO:1990712	HFE-transferrin receptor complex	B2M	IDA		Human	PMID:9990067
Cellular Component	GO:0016020	membrane	B2M	HDA		Human	PMID:19946888
Cellular Component	GO:0042824	MHC class I peptide loading complex	B2M	IDA		Human	PMID:21263072
Cellular Component	GO:0005886	plasma membrane	B2M	IDA		Human	GO_REF:0000052
Biological Process	GO:1990000	amyloid fibril formation	B2M	IDA		Human	PMID:28468825
Biological Process	GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I	B2M	IGI	UniProtKB:P04439	Human	PMID:24643698
Biological Process	GO:0002481	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent	B2m	IMP		Mouse	PMID:16299293
Biological Process	GO:0071281	cellular response to iron ion	B2M	IGI	UniProtKB:P02787,UniProtKB:Q07891,UniProtKB:Q30201,UniProtKB:Q9UP52	Human	PMID:18353247
Biological Process	GO:0071283	cellular response to iron(III) ion	B2m	IMP	MGI:MGI:1927183	Mouse	PMID:9531620
Biological Process	GO:0071316	cellular response to nicotine	B2M	IMP		Human	PMID:28213472
Biological Process	GO:0006879	intracellular iron ion homeostasis	B2M	IDA		Human	PMID:18353247
Biological Process	GO:0006826	iron ion transport	B2m	IMP	MGI:MGI:1927183	Mouse	PMID:9531620
Biological Process	GO:0007611	learning or memory	B2M	IDA		Human	PMID:26147761
Biological Process	GO:0007611	learning or memory	B2m	IMP		Mouse	MGI:MGI:6095052|PMID:28864206
Biological Process	GO:0007611	learning or memory	B2m	IMP		Mouse	MGI:MGI:5708430|PMID:26147761
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	B2m	IMP		Mouse	PMID:11113132
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	B2M	IDA		Human	PMID:28213472
Biological Process	GO:2000978	negative regulation of forebrain neuron differentiation	B2M	IDA		Human	PMID:26147761
Biological Process	GO:2000978	negative regulation of forebrain neuron differentiation	B2m	IMP		Mouse	MGI:MGI:5708430|PMID:26147761
Biological Process	GO:0050768	negative regulation of neurogenesis	B2M	IDA		Human	PMID:26147761
Biological Process	GO:0050768	negative regulation of neurogenesis	B2m	IMP		Mouse	MGI:MGI:5708430|PMID:26147761
Biological Process	GO:0010977	negative regulation of neuron projection development	B2m	IGI	MGI:MGI:95896	Mouse	PMID:20018625
Biological Process	GO:1900121	negative regulation of receptor binding	B2M	IDA		Human	PMID:9465039
Biological Process	GO:2000774	positive regulation of cellular senescence	B2M	IDA		Human	PMID:28213472
Biological Process	GO:1904434	positive regulation of ferrous iron binding	B2M	IGI	UniProtKB:P02786|UniProtKB:P02787|UniProtKB:Q30201|UniProtKB:Q9UP52	Human	PMID:18353247
Biological Process	GO:0032092	positive regulation of protein binding	B2M	IGI	UniProtKB:P02787,UniProtKB:Q07891,UniProtKB:Q30201,UniProtKB:Q9UP52	Human	PMID:18353247
Biological Process	GO:1900122	positive regulation of receptor binding	B2M	IGI	UniProtKB:P02787,UniProtKB:Q07891,UniProtKB:Q30201,UniProtKB:Q9UP52	Human	PMID:18353247
Biological Process	GO:0048260	positive regulation of receptor-mediated endocytosis	B2M	IGI	UniProtKB:P02787,UniProtKB:Q07891,UniProtKB:Q30201,UniProtKB:Q9UP52	Human	PMID:18353247
Biological Process	GO:0002726	positive regulation of T cell cytokine production	B2M	IDA		Human	PMID:24643698
Biological Process	GO:0001916	positive regulation of T cell mediated cytotoxicity	B2m	IMP		Mouse	PMID:16299293
Biological Process	GO:1904437	positive regulation of transferrin receptor binding	B2M	IGI	UniProtKB:P02786|UniProtKB:P02787|UniProtKB:Q30201|UniProtKB:Q9UP52	Human	PMID:18353247
Biological Process	GO:0051289	protein homotetramerization	B2M	IMP		Human	PMID:28468825
Biological Process	GO:0042026	protein refolding	B2m	IDA		Mouse	PMID:16920948
Biological Process	GO:0045646	regulation of erythrocyte differentiation	B2m	IMP	MGI:MGI:1927183	Mouse	PMID:9531620
Biological Process	GO:0034756	regulation of iron ion transport	B2M	IGI	UniProtKB:P02786|UniProtKB:P02787|UniProtKB:Q30201|UniProtKB:Q9UP52	Human	PMID:18353247
Biological Process	GO:0046686	response to cadmium ion	B2m	IEP		Rat	PMID:17327699|RGD:2293801
Biological Process	GO:0002237	response to molecule of bacterial origin	B2m	IMP		Mouse	PMID:16299293
Biological Process	GO:0009410	response to xenobiotic stimulus	B2m	IEP		Rat	PMID:17211973|RGD:1599430
Biological Process	GO:0001895	retina homeostasis	B2M	HEP		Human	PMID:23580065
Biological Process	GO:0007608	sensory perception of smell	B2m	IMP		Mouse	MGI:MGI:1860385|PMID:10912502
Biological Process	GO:0033077	T cell differentiation in thymus	B2m	IGI	MGI:MGI:95663	Mouse	PMID:18776904
Biological Process	GO:0001913	T cell mediated cytotoxicity	B2m	IMP		Mouse	PMID:16299293

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern