Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Aplnr

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes APLNR
- Mouse genes Aplnr
- Rat genes Aplnr
- Zfish genes aplnra,aplnrb
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Aplnr

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0060182	apelin receptor activity	aplnra	IDA		Zfish	PMID:30631305
Molecular Function	GO:0060182	apelin receptor activity	aplnrb	IDA		Zfish	PMID:30631305
Molecular Function	GO:0060182	apelin receptor activity	aplnrb	IDA		Zfish	PMID:17336906
Molecular Function	GO:0005515	protein binding	APLNR	IPI	UniProtKB:P30556	Human	PMID:21412239
Molecular Function	GO:0005515	protein binding	APLNR	IPI	UniProtKB:P41145	Human	PMID:22200678
Molecular Function	GO:0005515	protein binding	APLNR	IPI	UniProtKB:P30556	Human	PMID:22935142
Molecular Function	GO:0005515	protein binding	APLNR	IPI	UniProtKB:P29033	Human	PMID:32296183
Cellular Component	GO:0016020	membrane	Aplnr	IDA		Rat	PMID:14645236\|RGD:1304466
Cellular Component	GO:0005886	plasma membrane	APLNR	IDA		Human	PMID:25639753
Cellular Component	GO:0005886	plasma membrane	Aplnr	IDA		Rat	PMID:11359874\|RGD:12907555
Biological Process	GO:0007512	adult heart development	Aplnr	IMP		Mouse	MGI:MGI:5913613\|PMID:28663440
Biological Process	GO:0035479	angioblast cell migration from lateral mesoderm to midline	aplnrb	IGI	ZFIN:ZDB-GENE-060929-512	Zfish	PMID:26017639
Biological Process	GO:0035479	angioblast cell migration from lateral mesoderm to midline	aplnrb	IMP	ZFIN:ZDB-MRPHLNO-070522-4	Zfish	PMID:26017639
Biological Process	GO:0035479	angioblast cell migration from lateral mesoderm to midline	aplnra	IGI	ZFIN:ZDB-GENE-050913-90	Zfish	PMID:26017639
Biological Process	GO:0035479	angioblast cell migration from lateral mesoderm to midline	aplnra	IMP	ZFIN:ZDB-MRPHLNO-070525-6	Zfish	PMID:26017639
Biological Process	GO:0035904	aorta development	Aplnr	IMP		Mouse	MGI:MGI:5584055\|PMID:23603510
Biological Process	GO:0060183	apelin receptor signaling pathway	Aplnr	IMP		Mouse	MGI:MGI:5584055\|PMID:23603510
Biological Process	GO:0060183	apelin receptor signaling pathway	aplnrb	IDA		Zfish	PMID:30631305\|ZFIN:ZDB-PUB-190113-16
Biological Process	GO:0003171	atrioventricular valve development	Aplnr	IMP		Mouse	MGI:MGI:5584055\|PMID:23603510
Biological Process	GO:0048738	cardiac muscle tissue development	aplnrb	IMP		Zfish	PMID:17336906\|ZFIN:ZDB-PUB-070310-9
Biological Process	GO:0016477	cell migration	aplnrb	IMP		Zfish	PMID:17336906\|ZFIN:ZDB-PUB-070310-9
Biological Process	GO:0042074	cell migration involved in gastrulation	aplnra	IMP	ZFIN:ZDB-MRPHLNO-110413-7	Zfish	PMID:19922670
Biological Process	GO:0042074	cell migration involved in gastrulation	aplnra	IMP	ZFIN:ZDB-MRPHLNO-110413-2	Zfish	PMID:19922670
Biological Process	GO:0042074	cell migration involved in gastrulation	aplnra	IMP	ZFIN:ZDB-MRPHLNO-110413-3	Zfish	PMID:19922670
Biological Process	GO:0060976	coronary vasculature development	Aplnr	IMP		Mouse	MGI:MGI:5584055\|PMID:23603510
Biological Process	GO:0060976	coronary vasculature development	Aplnr	IMP		Mouse	MGI:MGI:5914956\|PMID:28890073
Biological Process	GO:0061371	determination of heart left/right asymmetry	aplnra	IMP	ZFIN:ZDB-MRPHLNO-070525-6	Zfish	PMID:31223282
Biological Process	GO:0061371	determination of heart left/right asymmetry	aplnrb	IMP	ZFIN:ZDB-MRPHLNO-070522-4	Zfish	PMID:31223282
Biological Process	GO:0007368	determination of left/right symmetry	aplnra	IMP	ZFIN:ZDB-MRPHLNO-070525-6	Zfish	PMID:31223282
Biological Process	GO:0071910	determination of liver left/right asymmetry	aplnra	IMP	ZFIN:ZDB-MRPHLNO-070525-6	Zfish	PMID:31223282
Biological Process	GO:0071910	determination of liver left/right asymmetry	aplnrb	IMP	ZFIN:ZDB-MRPHLNO-070522-4	Zfish	PMID:31223282
Biological Process	GO:0003272	endocardial cushion formation	Aplnr	IMP		Mouse	MGI:MGI:5584055\|PMID:23603510
Biological Process	GO:0035987	endodermal cell differentiation	aplnrb	IGI	ZFIN:ZDB-GENE-060929-512	Zfish	PMID:27077952
Biological Process	GO:0035987	endodermal cell differentiation	aplnra	IGI	ZFIN:ZDB-GENE-050913-90	Zfish	PMID:27077952
Biological Process	GO:0055113	epiboly involved in gastrulation with mouth forming second	aplnra	IMP	ZFIN:ZDB-MRPHLNO-110413-2	Zfish	PMID:19922670
Biological Process	GO:0055113	epiboly involved in gastrulation with mouth forming second	aplnra	IMP	ZFIN:ZDB-MRPHLNO-110413-7	Zfish	PMID:19922670
Biological Process	GO:0055113	epiboly involved in gastrulation with mouth forming second	aplnra	IMP	ZFIN:ZDB-MRPHLNO-110413-3	Zfish	PMID:19922670
Biological Process	GO:0090162	establishment of epithelial cell polarity	aplnrb	IMP	ZFIN:ZDB-GENO-170413-7	Zfish	PMID:27248505
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	APLNR	IMP		Human	PMID:25639753
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Aplnr	IMP		Rat	PMID:11359874\|RGD:12907555
Biological Process	GO:0007369	gastrulation	aplnrb	IMP		Zfish	PMID:17336905
Biological Process	GO:0001702	gastrulation with mouth forming second	aplnrb	IMP		Zfish	PMID:17336905\|ZFIN:ZDB-PUB-070310-8
Biological Process	GO:0007507	heart development	aplnra	IGI	ZFIN:ZDB-GENE-050913-90	Zfish	PMID:17336906\|ZFIN:ZDB-PUB-070310-9
Biological Process	GO:0007507	heart development	aplnrb	IMP		Zfish	PMID:17336905\|ZFIN:ZDB-PUB-070310-8
Biological Process	GO:0007507	heart development	aplnrb	IMP		Zfish	PMID:24316148\|ZFIN:ZDB-PUB-140106-3
Biological Process	GO:0007507	heart development	aplnrb	IMP		Zfish	PMID:17336906\|ZFIN:ZDB-PUB-070310-9
Biological Process	GO:0007507	heart development	aplnrb	IMP	ZFIN:ZDB-MRPHLNO-070522-4	Zfish	PMID:17336905
Biological Process	GO:0007507	heart development	aplnrb	IMP	ZFIN:ZDB-GENO-070525-1	Zfish	PMID:17336906
Biological Process	GO:0007507	heart development	aplnrb	IMP	ZFIN:ZDB-MRPHLNO-070531-1	Zfish	PMID:17336906
Biological Process	GO:0007507	heart development	aplnrb	IGI	ZFIN:ZDB-GENE-060929-512	Zfish	PMID:27077952
Biological Process	GO:0007507	heart development	aplnra	IGI	ZFIN:ZDB-GENE-050913-90	Zfish	PMID:27077952
Biological Process	GO:0001947	heart looping	Aplnr	IMP		Mouse	MGI:MGI:5584055\|PMID:23603510
Biological Process	GO:0070121	Kupffer's vesicle development	aplnra	IMP	ZFIN:ZDB-MRPHLNO-070525-6	Zfish	PMID:31223282
Biological Process	GO:0001945	lymph vessel development	aplnra	IMP	ZFIN:ZDB-MRPHLNO-140317-4	Zfish	PMID:24311379
Biological Process	GO:0008078	mesodermal cell migration	aplnrb	IMP	ZFIN:ZDB-MRPHLNO-070531-1	Zfish	PMID:17336906
Biological Process	GO:0043951	negative regulation of cAMP-mediated signaling	APLNR	IMP		Human	PMID:25639753
Biological Process	GO:0043951	negative regulation of cAMP-mediated signaling	Aplnr	IMP		Rat	PMID:11359874\|RGD:12907555
Biological Process	GO:0010629	negative regulation of gene expression	Aplnr	IMP		Mouse	MGI:MGI:5584055\|PMID:23603510
Biological Process	GO:0045766	positive regulation of angiogenesis	APLNR	IMP		Human	PMID:25639753
Biological Process	GO:1903589	positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	Aplnr	IMP		Mouse	MGI:MGI:5914956\|PMID:28890073
Biological Process	GO:0031065	positive regulation of histone deacetylation	Aplnr	IMP		Mouse	MGI:MGI:5584055\|PMID:23603510
Biological Process	GO:1904325	positive regulation of inhibitory G protein-coupled receptor phosphorylation	APLNR	IMP		Human	PMID:25639753
Biological Process	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	APLNR	IMP		Human	PMID:25639753
Biological Process	GO:0050878	regulation of body fluid levels	Aplnr	IMP		Rat	PMID:12787050\|RGD:1304389
Biological Process	GO:1903596	regulation of gap junction assembly	Aplnr	IMP		Mouse	MGI:MGI:5584055\|PMID:23603510
Biological Process	GO:0010468	regulation of gene expression	Aplnr	IMP		Mouse	MGI:MGI:5584055\|PMID:23603510
Biological Process	GO:1900107	regulation of nodal signaling pathway	aplnrb	IGI	ZFIN:ZDB-GENE-060929-512	Zfish	PMID:27077952
Biological Process	GO:1900107	regulation of nodal signaling pathway	aplnra	IGI	ZFIN:ZDB-GENE-050913-90	Zfish	PMID:27077952
Biological Process	GO:0002040	sprouting angiogenesis	aplnra	IGI	ZFIN:ZDB-GENO-220906-5	Zfish	PMID:32955436
Biological Process	GO:0002040	sprouting angiogenesis	aplnrb	IGI	ZFIN:ZDB-GENO-220906-5	Zfish	PMID:32955436
Biological Process	GO:0035886	vascular associated smooth muscle cell differentiation	Aplnr	IMP		Mouse	MGI:MGI:5584055\|PMID:23603510
Biological Process	GO:0001944	vasculature development	Aplnr	IMP		Mouse	MGI:MGI:5584055\|PMID:23603510
Biological Process	GO:0001570	vasculogenesis	Aplnr	IMP		Mouse	MGI:MGI:5913613\|PMID:28663440
Biological Process	GO:0060841	venous blood vessel development	Aplnr	IMP		Mouse	MGI:MGI:5584055\|PMID:23603510
Biological Process	GO:0060412	ventricular septum morphogenesis	Aplnr	IMP		Mouse	MGI:MGI:5584055\|PMID:23603510

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.