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Aplnr Gene Detail
Summary
  • Symbol
    Aplnr
  • Name
    apelin receptor
  • Synonyms
    Agtrl1, apelin receptor, APJ, msr/apj
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346086
    NCBI Gene: 23796
  • Gene Overview
    MyGene.info: APLNR
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:85136225-85139923 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3699 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 49.45 cM, cytoband E1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    APLNR, apelin receptor
  • Vertebrate Orthologs
    7
  • Human Ortholog
    APLNR, apelin receptor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AGTRL1, APJ, APJR, HG11
  • Links
    NCBI Gene ID: 187
    neXtProt AC: NX_P35414
    UniProt: P35414

  • Chr Location
    11q12.1; chr11:57233577-57237453 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 5 alleles in 5 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit early lethality, decreased cardiac contractility, and decreased exercise endurance. Mice for another knock-out allele develop pulmonary venoocclusive disease with heart right ventricle hypertrophy and elevated pulmonary pressures.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000013465 VEGA Gene Model | MGI Sequence Detail 3699 C57BL/6J ±  kb
    transcript OTTMUST00000032555 VEGA | MGI Sequence Detail 3699 Not Applicable  
    polypeptide OTTMUSP00000014455 VEGA | MGI Sequence Detail 377 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      69 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 44
      cDNA 43
      Other 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 79
      Developmental Gene Expression 21
      Gene Ontology 6
      Phenotypes 26
    • Earliest
      J:56817 Devic E, et al., Amino acid sequence and embryonic expression of msr/apj, the mouse homolog of Xenopus X-msr and human APJ. Mech Dev. 1999 Jun;84(1-2):199-203
    • Latest
      J:259848 Chal J, et al., Recapitulating early development of mouse musculoskeletal precursors of the paraxial mesoderm in vitro. Development. 2018 Mar 19;145(6)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory