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Aplnr Gene Detail
Summary
  • Symbol
    Aplnr
  • Name
    apelin receptor
  • Synonyms
    Agtrl1, apelin receptor, APJ, msr/apj
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346086
    NCBI Gene: 23796
  • Gene Overview
    MyGene.info: APLNR
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:85136360-85139923 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 49.45 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    68 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346086
protein coding gene Chr2:85136225-85139923 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025922
protein coding gene Chr2:85847149-85850847 (+)
A/J MGP_AJ_G0025896
protein coding gene Chr2:82511995-82515696 (+)
AKR/J MGP_AKRJ_G0025866
protein coding gene Chr2:84645253-84648954 (+)
BALB/cJ MGP_BALBcJ_G0025893
protein coding gene Chr2:82642815-82646516 (+)
C3H/HeJ MGP_C3HHeJ_G0025652
protein coding gene Chr2:84878782-84882483 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026339
protein coding gene Chr2:88494503-88498201 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023741
protein coding gene Chr2:79335941-79339670 (+)
CAST/EiJ MGP_CASTEiJ_G0025113
protein coding gene Chr2:85431782-85435478 (+)
CBA/J MGP_CBAJ_G0025633
protein coding gene Chr2:91644354-91648055 (+)
DBA/2J MGP_DBA2J_G0025764
protein coding gene Chr2:82047989-82051690 (+)
FVB/NJ MGP_FVBNJ_G0025727
protein coding gene Chr2:81303166-81306855 (+)
LP/J MGP_LPJ_G0025852
protein coding gene Chr2:85628714-85632415 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025757
protein coding gene Chr2:93957067-93960759 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026395
protein coding gene Chr2:84889679-84893371 (+)
PWK/PhJ MGP_PWKPhJ_G0024857
protein coding gene Chr2:81897948-81901637 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024661
protein coding gene Chr2:85017928-85021628 (+)
WSB/EiJ MGP_WSBEiJ_G0025183
protein coding gene Chr2:85549144-85552842 (+)



Homology
more
  • Human Ortholog
    APLNR, apelin receptor
  • Vertebrate Orthologs
    7
  • Human Ortholog
    APLNR, apelin receptor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AGTRL1, APJ, APJR, HG11
  • Links
    NCBI Gene ID: 187
    neXtProt AC: NX_P35414
    UniProt: P35414

  • Chr Location
    11q12.1; chr11:57233577-57237453 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 5 alleles in 5 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit early lethality, decreased cardiac contractility, and decreased exercise endurance. Mice for another knock-out allele develop pulmonary venoocclusive disease with heart right ventricle hypertrophy and elevated pulmonary pressures.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 23796 NCBI Gene Model | MGI Sequence Detail 3564 C57BL/6J ±  kb
    transcript NM_011784 RefSeq | MGI Sequence Detail 3573 C57BL/6  
    polypeptide Q9WV08 UniProt | EBI | MGI Sequence Detail 377 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 44
      cDNA 43
      Other 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 21
      Gene Ontology 6
      Phenotypes 26
    • Earliest
      J:56817 Devic E, et al., Amino acid sequence and embryonic expression of msr/apj, the mouse homolog of Xenopus X-msr and human APJ. Mech Dev. 1999 Jun;84(1-2):199-203
    • Latest
      J:259848 Chal J, et al., Recapitulating early development of mouse musculoskeletal precursors of the paraxial mesoderm in vitro. Development. 2018 Mar 19;145(6)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory