About   Help   FAQ
Aplnr
Gene Detail
 Symbol
Name
ID
Aplnr
apelin receptor
MGI:1346086
Synonyms Agtrl1, apelin receptor, APJ, msr/apj
Feature Type protein coding gene
Genetic Map
Chromosome 2
49.45 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:85136225-85139923 bp, + strand
From VEGA annotation of GRCm38

  3699 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3784  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Protein SuperFamily: apelin receptor
Gene Tree: Aplnr

Human
homologs
Human Homolog APLNR, apelin receptor
NCBI Gene ID 187
neXtProt AC  NX_P35414
Human Synonyms  AGTRL1, APJ, APJR, HG11
Human Chr (Location)  11q12; chr11:57233577-57237453 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Genomic Mutations involving Aplnr (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit early lethality, decreased cardiac contractility, and decreased exercise endurance.
 
Interactions
Aplnr interacts with 233 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process gastrulation, G-protein coupled receptor signaling pathway, ...
Component integral component of membrane, membrane, ...
Function G-protein coupled receptor activity, signal transducer activity
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (102)    Tissues (78)    Images (30)
Theiler Stages: 11, 12, 13, 14, 15, 17, 19, 23, 28
Assay TypeResults
RNA in situ 102
cDNA source data(40)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(42) cDNA(42)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000013465 (Evidence)
Ensembl Gene ModelENSMUSG00000044338 (Evidence)
Entrez Gene23796 (Evidence)
UniGene29368
DFCITC1576841
DoTSDT.101228518, DT.91294039, DT.94170330, DT.97375808
NIA Mouse Gene IndexU002007
Consensus CDS ProjectCCDS16201.1
International Mouse Knockout Project StatusAplnr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013465 VEGA Gene Model | MGI Sequence Detail 3699 C57BL/6J ±  kb
transcript OTTMUST00000032555 VEGA | MGI Sequence Detail 3699 Not Applicable 
polypeptide OTTMUSP00000014455 VEGA | MGI Sequence Detail 377 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(69 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020279 Apelin receptor, C-terminal
InterPro IPR003904 APJ receptor
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001120 apelin receptor
References (Earliest) J:56817 Devic E, et al., Amino acid sequence and embryonic expression of msr/apj, the mouse homolog of Xenopus X-msr and human APJ. Mech Dev. 1999 Jun;84(1-2):199-203
(Latest) J:204703 Zhang Z, et al., Accelerated coronary angiogenesis by vegfr1-knockout endocardial cells. PLoS One. 2013;8(7):e70570
All references(54)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory