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Aplnr
Gene Detail
Symbol

Name
ID
Aplnr
apelin receptor
MGI:1346086
Synonyms
Agtrl1, apelin receptor, APJ, msr/apj
Feature Type
protein coding gene
Genetic Map
Chromosome 2
49.45 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:85136225-85139923 bp, + strand
From VEGA annotation of GRCm38

  3699 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3784  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

HCOP human homology predictions: APLNR
Protein SuperFamily: apelin receptor
Gene Tree: Aplnr

Human
homologs
APLNR, apelin receptor
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 187
neXtProt AC: NX_P35414

Human Synonyms: AGTRL1, APJ, APJR, HG11

Human Chr (Location): 11q12; chr11:57233577-57237453 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Genomic Mutations involving Aplnr (2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit early lethality, decreased cardiac contractility, and decreased exercise endurance.
 
Interactions
Aplnr interacts with 232 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (14 records)
Data Summary: Results (102)    Tissues (78)    Images (30)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 102
cDNA source data(40)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase aplnr ; ZFIN aplnra, aplnrb    NEW 
Molecular
reagents
All nucleic(42) cDNA(42)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000013465 (Evidence)
Ensembl Gene Model ENSMUSG00000044338 (Evidence)
Entrez Gene 23796 (Evidence)
UniGene 29368
DFCI TC1576841
DoTS DT.97375808, DT.94170330, DT.91294039, DT.101228518
NIA Mouse Gene Index U002007
Consensus CDS Project CCDS16201.1
International Mouse Phenotyping Consortium Status Aplnr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013465 VEGA Gene Model | MGI Sequence Detail 3699 C57BL/6J ±  kb
transcript OTTMUST00000032555 VEGA | MGI Sequence Detail 3699 Not Applicable 
polypeptide OTTMUSP00000014455 VEGA | MGI Sequence Detail 377 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(69 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020279 Apelin receptor, C-terminal
InterPro IPR003904 APJ receptor
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001120 apelin receptor
References
(Earliest) J:56817 Devic E, et al., Amino acid sequence and embryonic expression of msr/apj, the mouse homolog of Xenopus X-msr and human APJ. Mech Dev. 1999 Jun;84(1-2):199-203
(Latest) J:213291 Kang Y, et al., Apelin-APJ signaling is a critical regulator of endothelial MEF2 activation in cardiovascular development. Circ Res. 2013 Jun 21;113(1):22-31
All references(54)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory