Gene Expression Literature Summary

• Symbol: Aplnr
• Name: apelin receptor
• ID: MGI:1346086

41 matching records from 41 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E6.5	E7	E7.5	E8	E8.5	E9	E9.5	E10	E10.5	E11.5	E12.5	E13	E13.5	E14.5	E15	E15.5	E16.5	E17	E17.5	E18.5	P
Immunohistochemistry (section)									1	1	1	1	1	1				1		1	1
In situ RNA (section)		1	2	2	2	1	3		3	1	1		1	2		3	1		1	1	5
Immunohistochemistry (whole mount)	1	1	1	1			1			1	1	1	2	2	1	3	1
In situ RNA (whole mount)	1	1	4	3	5	2	6	2	2	2	1		1	1							1
In situ reporter (knock in)																					1
RT-PCR					1		3		1	4	3	1	1	2		1	1				3

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Aplnr  apelin receptor   (Synonyms: Agtrl1, apelin receptor, APJ, msr/apj)
Results	Reference
14	J:288357 Arita Y, Nakaoka Y, Matsunaga T, Kidoya H, Yamamizu K, Arima Y, Kataoka-Hashimoto T, Ikeoka K, Yasui T, Masaki T, Yamamoto K, Higuchi K, Park JS, Shirai M, Nishiyama K, Yamagishi H, Otsu K, Kurihara H, Minami T, Yamauchi-Takihara K, Koh GY, Mochizuki N, Takakura N, Sakata Y, Yamashita JK, Komuro I, Myocardium-derived angiopoietin-1 is essential for coronary vein formation in the developing heart. Nat Commun. 2014 Jul 29;5:4552
5	J:237925 Azizoglu DB, Chong DC, Villasenor A, Magenheim J, Barry DM, Lee S, Marty-Santos L, Fu S, Dor Y, Cleaver O, Vascular development in the vertebrate pancreas. Dev Biol. 2016 Dec 01;420(1):67-78
3*	J:335085 Baral K, D'amato G, Kuschel B, Bogan F, Jones BW, Large CL, Whatley JD, Red-Horse K, Sharma B, APJ+ cells in the SHF contribute to the cells of aorta and pulmonary trunk through APJ signaling. Dev Biol. 2023 Apr 8;498:77-86
1	J:286694 Barry DM, McMillan EA, Kunar B, Lis R, Zhang T, Lu T, Daniel E, Yokoyama M, Gomez-Salinero JM, Sureshbabu A, Cleaver O, Di Lorenzo A, Choi ME, Xiang J, Redmond D, Rabbany SY, Muthukumar T, Rafii S, Molecular determinants of nephron vascular specialization in the kidney. Nat Commun. 2019 Dec 13;10(1):5705
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
3	J:330573 Bonet F, Anez SB, Inacio JM, Futschik ME, Belo JA, CCBE1 Is Essential for Epicardial Function during Myocardium Development. Int J Mol Sci. 2022 Oct 20;23(20)
1	J:338402 Cao X, Li T, Xu B, Ding K, Li W, Shen B, Chu M, Zhu D, Rui L, Shang Z, Li X, Wang Y, Zheng S, Alitalo K, Liu G, Tang J, Kubota Y, He Y, Endothelial TIE1 Restricts Angiogenic Sprouting to Coordinate Vein Assembly in Synergy With Its Homologue TIE2. Arterioscler Thromb Vasc Biol. 2023 Aug;43(8):e323-e338
1*	J:259848 Chal J, Al Tanoury Z, Oginuma M, Moncuquet P, Gobert B, Miyanari A, Tassy O, Guevara G, Hubaud A, Bera A, Sumara O, Garnier JM, Kennedy L, Knockaert M, Gayraud-Morel B, Tajbakhsh S, Pourquie O, Recapitulating early development of mouse musculoskeletal precursors of the paraxial mesoderm in vitro. Development. 2018 Mar 19;145(6):dev157339
1*	J:331053 Chandrasekaran P, Negretti NM, Sivakumar A, Liberti DC, Wen H, Peers de Nieuwburgh M, Wang JY, Michki NS, Chaudhry FN, Kaur S, Lu M, Jin A, Zepp JA, Young LR, Sucre JMS, Frank DB, CXCL12 defines lung endothelial heterogeneity and promotes distal vascular growth. Development. 2022 Nov 1;149(21):dev200909
1	J:306392 Chen F, Chen J, Wang H, Tang H, Huang L, Wang S, Wang X, Fang X, Liu J, Li L, Ouyang K, Han Z, Histone Lysine Methyltransferase SETD2 Regulates Coronary Vascular Development in Embryonic Mouse Hearts. Front Cell Dev Biol. 2021;9:651655
3	J:174608 Chong DC, Koo Y, Xu K, Fu S, Cleaver O, Stepwise arteriovenous fate acquisition during mammalian vasculogenesis. Dev Dyn. 2011 Sep;240(9):2153-65
2	J:176969 Costello I, Pimeisl IM, Drager S, Bikoff EK, Robertson EJ, Arnold SJ, The T-box transcription factor Eomesodermin acts upstream of Mesp1 to specify cardiac mesoderm during mouse gastrulation. Nat Cell Biol. 2011 Sep;13(9):1084-91
2	J:164936 D'Aniello C, Lonardo E, Iaconis S, Guardiola O, Liguoro AM, Liguori GL, Autiero M, Carmeliet P, Minchiotti G, G protein-coupled receptor APJ and its ligand apelin act downstream of Cripto to specify embryonic stem cells toward the cardiac lineage through extracellular signal-regulated kinase/p70S6 kinase signaling pathway. Circ Res. 2009 Jul 31;105(3):231-8
4*	J:56817 Devic E, Rizzoti K, Bodin S, Knibiehler B, Audigier Y, Amino acid sequence and embryonic expression of msr/apj, the mouse homolog of Xenopus X-msr and human APJ. Mech Dev. 1999 Jun;84(1-2):199-203
11	J:243623 Freyer L, Hsu CW, Nowotschin S, Pauli A, Ishida J, Kuba K, Fukamizu A, Schier AF, Hoodless PA, Dickinson ME, Hadjantonakis AK, Loss of Apela Peptide in Mice Causes Low Penetrance Embryonic Lethality and Defects in Early Mesodermal Derivatives. Cell Rep. 2017 Aug 29;20(9):2116-2130
2	J:297312 Gillich A, Zhang F, Farmer CG, Travaglini KJ, Tan SY, Gu M, Zhou B, Feinstein JA, Krasnow MA, Metzger RJ, Capillary cell-type specialization in the alveolus. Nature. 2020 Oct;586(7831):785-789
3	J:244834 Ho L, van Dijk M, Chye STJ, Messerschmidt DM, Chng SC, Ong S, Yi LK, Boussata S, Goh GH, Afink GB, Lim CY, Dunn NR, Solter D, Knowles BB, Reversade B, ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice. Science. 2017 Aug 18;357(6352):707-713
4	J:316080 Jackson M, Fidanza A, Taylor AH, Rybtsov S, Axton R, Kydonaki M, Meek S, Burdon T, Medvinsky A, Forrester LM, Modulation of APLNR Signaling Is Required during the Development and Maintenance of the Hematopoietic System. Stem Cell Reports. 2021 Apr 13;16(4):727-740
4*	J:121633 Kalin RE, Kretz MP, Meyer AM, Kispert A, Heppner FL, Brandli AW, Paracrine and autocrine mechanisms of apelin signaling govern embryonic and tumor angiogenesis. Dev Biol. 2007 May 15;305(2):599-614
2	J:320186 Kalisch-Smith JI, Morris EC, Strevens MAA, Redpath AN, Klaourakis K, Szumska D, Outhwaite JE, Sun X, Vieira JM, Smart N, De Val S, Riley PR, Sparrow DB, Analysis of Placental Arteriovenous Formation Reveals New Insights Into Embryos With Congenital Heart Defects. Front Genet. 2021;12:806136
1	J:213291 Kang Y, Kim J, Anderson JP, Wu J, Gleim SR, Kundu RK, McLean DL, Kim JD, Park H, Jin SW, Hwa J, Quertermous T, Chun HJ, Apelin-APJ signaling is a critical regulator of endothelial MEF2 activation in cardiovascular development. Circ Res. 2013 Jun 21;113(1):22-31
2	J:215739 Kazanskaya O, Ohkawara B, Heroult M, Wu W, Maltry N, Augustin HG, Niehrs C, The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development. Development. 2008 Nov;135(22):3655-64
5	J:239279 Kidoya H, Naito H, Muramatsu F, Yamakawa D, Jia W, Ikawa M, Sonobe T, Tsuchimochi H, Shirai M, Adams RH, Fukamizu A, Takakura N, APJ Regulates Parallel Alignment of Arteries and Veins in the Skin. Dev Cell. 2015 May 04;33(3):247-59
4	J:131824 Kidoya H, Ueno M, Yamada Y, Mochizuki N, Nakata M, Yano T, Fujii R, Takakura N, Spatial and temporal role of the apelin/APJ system in the caliber size regulation of blood vessels during angiogenesis. EMBO J. 2008 Feb 6;27(3):522-34
1*	J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
1	J:230747 Li H, Koo Y, Mao X, Sifuentes-Dominguez L, Morris LL, Jia D, Miyata N, Faulkner RA, van Deursen JM, Vooijs M, Billadeau DD, van de Sluis B, Cleaver O, Burstein E, Endosomal sorting of Notch receptors through COMMD9-dependent pathways modulates Notch signaling. J Cell Biol. 2015 Nov 9;211(3):605-17
2	J:332317 Lin X, Swedlund B, Ton MN, Ghazanfar S, Guibentif C, Paulissen C, Baudelet E, Plaindoux E, Achouri Y, Calonne E, Dubois C, Mansfield W, Zaffran S, Marioni JC, Fuks F, Gottgens B, Lescroart F, Blanpain C, Mesp1 controls the chromatin and enhancer landscapes essential for spatiotemporal patterning of early cardiovascular progenitors. Nat Cell Biol. 2022 Jul;24(7):1114-1128
3	J:317975 Lu P, Wang Y, Liu Y, Wang Y, Wu B, Zheng D, Harvey RP, Zhou B, Perinatal angiogenesis from pre-existing coronary vessels via DLL4-NOTCH1 signalling. Nat Cell Biol. 2021 Sep;23(9):967-977
3*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
4	J:315702 Nomaru H, Liu Y, De Bono C, Righelli D, Cirino A, Wang W, Song H, Racedo SE, Dantas AG, Zhang L, Cai CL, Angelini C, Christiaen L, Kelly RG, Baldini A, Zheng D, Morrow BE, Single cell multi-omic analysis identifies a Tbx1-dependent multilineage primed population in murine cardiopharyngeal mesoderm. Nat Commun. 2021 Nov 17;12(1):6645
2	J:286013 Outhwaite JE, Patel J, Simmons DG, Secondary Placental Defects in Cxadr Mutant Mice. Front Physiol. 2019;10:622
1	J:201133 Rattner A, Yu H, Williams J, Smallwood PM, Nathans J, Endothelin-2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):E3830-E3839
2	J:158886 Red-Horse K, Ueno H, Weissman IL, Krasnow MA, Coronary arteries form by developmental reprogramming of venous cells. Nature. 2010 Mar 25;464(7288):549-53
1*	J:338018 Stathopoulou A, Wang P, Thellier C, Kelly RG, Zheng D, Scambler PJ, CHARGE syndrome-associated CHD7 acts at ISL1-regulated enhancers to modulate second heart field gene expression. Cardiovasc Res. 2023 Apr 13;
1*	J:161404 Stevens J, Ermakov A, Braganca J, Hilton H, Underhill P, Bhattacharya S, Brown NA, Norris DP, Analysis of the asymmetrically expressed Ablim1 locus reveals existence of a lateral plate Nodal-independent left sided signal and an early, left-right independent role for nodal flow. BMC Dev Biol. 2010;10:54
2*	J:141291 Tamplin OJ, Kinzel D, Cox BJ, Bell CE, Rossant J, Lickert H, Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. BMC Genomics. 2008;9(1):511
1	J:168146 Teo AK, Arnold SJ, Trotter MW, Brown S, Ang LT, Chng Z, Robertson EJ, Dunn NR, Vallier L, Pluripotency factors regulate definitive endoderm specification through eomesodermin. Genes Dev. 2011 Feb 1;25(3):238-50
2	J:324118 Wang G, Wen B, Deng Z, Zhang Y, Kolesnichenko OA, Ustiyan V, Pradhan A, Kalin TV, Kalinichenko VV, Endothelial progenitor cells stimulate neonatal lung angiogenesis through FOXF1-mediated activation of BMP9/ACVRL1 signaling. Nat Commun. 2022 Apr 19;13(1):2080
1	J:251917 Wang Y, Wu B, Lu P, Zhang D, Wu B, Varshney S, Del Monte-Nieto G, Zhuang Z, Charafeddine R, Kramer AH, Sibinga NE, Frangogiannis NG, Kitsis RN, Adams RH, Alitalo K, Sharp DJ, Harvey RP, Stanley P, Zhou B, Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1. Nat Commun. 2017 Sep 18;8(1):578
2	J:327590 Xia S, Menden HL, Townley N, Mabry SM, Johnston J, Nyp MF, Heruth DP, Korfhagen T, Sampath V, Delta-like 4 is required for pulmonary vascular arborization and alveolarization in the developing lung. JCI Insight. 2021 Apr 8;6(7)
1	J:204703 Zhang Z, Zhou B, Accelerated coronary angiogenesis by vegfr1-knockout endocardial cells. PLoS One. 2013;8(7):e70570