Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes APLF
  • Mouse genes Aplf
  • Rat genes Aplf
  • Zfish genes aplf
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Aplf

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008408	3'-5' exonuclease activity	APLF	IDA		Human	PMID:17396150
Molecular Function	GO:0160002	ADP-D-ribose modification-dependent protein binding	APLF	IDA		Human	PMID:18172500
Molecular Function	GO:0004520	DNA endonuclease activity	APLF	IDA		Human	PMID:17396150
Molecular Function	GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	APLF	IDA		Human	PMID:17396150
Molecular Function	GO:0042393	histone binding	APLF	IDA		Human	PMID:21211722
Molecular Function	GO:0042393	histone binding	APLF	IDA		Human	PMID:29905837
Molecular Function	GO:0140713	histone chaperone activity	APLF	IDA		Human	PMID:21211722
Molecular Function	GO:0140713	histone chaperone activity	APLF	IDA		Human	PMID:29905837
Molecular Function	GO:0000166	nucleotide binding	APLF	IDA		Human	PMID:18172500
Molecular Function	GO:0072572	poly-ADP-D-ribose binding	APLF	IDA		Human	PMID:18172500
Molecular Function	GO:0072572	poly-ADP-D-ribose binding	APLF	IDA		Human	PMID:21211721
Molecular Function	GO:0072572	poly-ADP-D-ribose binding	APLF	IDA		Human	PMID:30104678
Molecular Function	GO:0005515	protein binding	APLF	IPI	UniProtKB:P18887	Human	PMID:17353262
Molecular Function	GO:0005515	protein binding	APLF	IPI	UniProtKB:Q13426	Human	PMID:17353262
Molecular Function	GO:0005515	protein binding	APLF	IPI	UniProtKB:P09874	Human	PMID:17396150
Molecular Function	GO:0005515	protein binding	APLF	IPI	UniProtKB:P13010	Human	PMID:17396150
Molecular Function	GO:0005515	protein binding	APLF	IPI	UniProtKB:P18887	Human	PMID:17396150
Molecular Function	GO:0005515	protein binding	APLF	IPI	UniProtKB:P49917	Human	PMID:17396150
Molecular Function	GO:0005515	protein binding	APLF	IPI	UniProtKB:Q13426	Human	PMID:17396150
Molecular Function	GO:0005515	protein binding	APLF	IPI	UniProtKB:P09874	Human	PMID:18172500
Molecular Function	GO:0005515	protein binding	APLF	IPI	UniProtKB:P09874	Human	PMID:20098424
Molecular Function	GO:0005515	protein binding	APLF	IPI	UniProtKB:P13010	Human	PMID:20098424
Molecular Function	GO:0005515	protein binding	APLF	IPI	UniProtKB:P13010	Human	PMID:23178593
Molecular Function	GO:0005515	protein binding	APLF	IPI	UniProtKB:P18887	Human	PMID:23178593
Molecular Function	GO:0005515	protein binding	APLF	IPI	UniProtKB:P49917	Human	PMID:23178593
Molecular Function	GO:0005515	protein binding	APLF	IPI	UniProtKB:Q13426	Human	PMID:23178593
Molecular Function	GO:0005515	protein binding	APLF	IPI	UniProtKB:P12956	Human	PMID:23689425
Molecular Function	GO:0005515	protein binding	APLF	IPI	UniProtKB:P13010	Human	PMID:23689425
Molecular Function	GO:0005515	protein binding	APLF	IPI	UniProtKB:Q53SE7	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	APLF	IPI	UniProtKB:P09874	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	APLF	IPI	UniProtKB:P13010	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	APLF	IPI	UniProtKB:P18887	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	APLF	IPI	UniProtKB:P49917	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	APLF	IPI	UniProtKB:Q13426	Human	PMID:28514442
Molecular Function	GO:0044183	protein folding chaperone	APLF	EXP		Human	PMID:29905837
Cellular Component	GO:0005829	cytosol	Aplf	IDA		Mouse	MGI:MGI:6780835|PMID:33277378
Cellular Component	GO:0005654	nucleoplasm	APLF	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	APLF	IDA		Human	PMID:17396150
Cellular Component	GO:0005634	nucleus	APLF	IDA		Human	PMID:18172500
Cellular Component	GO:0005634	nucleus	Aplf	IDA		Mouse	MGI:MGI:6780835|PMID:33277378
Cellular Component	GO:0090734	site of DNA damage	APLF	IDA		Human	PMID:30104678
Cellular Component	GO:0090734	site of DNA damage	APLF	IDA		Human	PMID:21211722
Cellular Component	GO:0035861	site of double-strand break	APLF	IDA		Human	PMID:23689425
Cellular Component	GO:0035861	site of double-strand break	APLF	IDA		Human	PMID:21211721
Biological Process	GO:0006974	DNA damage response	APLF	IDA		Human	PMID:17396150
Biological Process	GO:0006281	DNA repair	APLF	IDA		Human	PMID:21211722
Biological Process	GO:0006281	DNA repair	APLF	IDA		Human	PMID:30104678
Biological Process	GO:0140861	DNA repair-dependent chromatin remodeling	APLF	IDA		Human	PMID:21211722
Biological Process	GO:0140861	DNA repair-dependent chromatin remodeling	APLF	IDA		Human	PMID:29905837
Biological Process	GO:0006302	double-strand break repair	APLF	IMP		Human	PMID:17396150
Biological Process	GO:0006302	double-strand break repair	Aplf	IMP	MGI:MGI:4128102	Mouse	PMID:21211721
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	APLF	IMP		Human	PMID:23689425
Biological Process	GO:0007566	embryo implantation	Aplf	IMP		Mouse	MGI:MGI:6780835|PMID:33277378
Biological Process	GO:0051106	positive regulation of DNA ligation	APLF	IGI	UniProtKB:Q9Y6F1	Human	PMID:21211721
Biological Process	GO:0071168	protein localization to chromatin	APLF	IDA		Human	PMID:21211722
Biological Process	GO:0010717	regulation of epithelial to mesenchymal transition	Aplf	IMP		Mouse	MGI:MGI:6780835|PMID:33277378
Biological Process	GO:0045191	regulation of isotype switching	Aplf	IMP	MGI:MGI:4128102	Mouse	PMID:21211721
Biological Process	GO:0000012	single strand break repair	APLF	IMP		Human	PMID:17396150

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern