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Aplf Gene Detail
Summary
  • Symbol
    Aplf
  • Name
    aprataxin and PNKP like factor
  • Synonyms
    2010301N04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919353
    NCBI Gene: 72103
Location & Maps
more
  • Sequence Map
    Chr6:87628424-87672193 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      43770 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 38.52 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    APLF, aprataxin and PNKP like factor
  • Vertebrate Orthologs
    8
  • Human Ortholog
    APLF, aprataxin and PNKP like factor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    APFL, C2orf13, PALF, Xip1, ZCCHH1
  • Links
    NCBI Gene ID: 200558
    neXtProt AC: NX_Q8IW19

  • Chr Location
    2p13.3; chr2:68467559-68580162 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Gene trapped
    3
  • Spontaneous
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Aplf
  • Incidental Mutations
Mice homozygous for a gene trap allele exhibit decreased repair of gamma irradiation-induced DNA damage and increased microhomology at class switch recombination junctions in B cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000057210 VEGA Gene Model | MGI Sequence Detail 43770 C57BL/6J ±  kb
transcript OTTMUST00000140848 VEGA | MGI Sequence Detail 1889 Not Applicable  
polypeptide OTTMUSP00000073699 VEGA | MGI Sequence Detail 499 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    168 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 24
    cDNA 24

    Microarray probesets 4
Other
Accession IDs
less
MGI:2141420
References
more
  • Summaries
    All 24
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:168260 Rulten SL, et al., PARP-3 and APLF function together to accelerate nonhomologous end-joining. Mol Cell. 2011 Jan 7;41(1):33-45

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory