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Gene Ontology Browser
Term Detail
GO term:DNA-(apurinic or apyrimidinic site) lyase activity
Synonym: AP endonuclease class I activity
Synonym: AP lyase activity
Synonym: AP site-DNA 5'-phosphomonoester-lyase activity
Synonym: deoxyribonuclease (apurinic or apyrimidinic) activity
Synonym: DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase activity
Synonym: E. coli endonuclease III
Synonym: E. coli endonuclease III activity
Synonym: endodeoxyribonuclease (apurinic or apyrimidinic) activity
Synonym: endonuclease VIII activity
Synonym: micrococcus luteus UV endonuclease
Synonym: Micrococcus luteus UV endonuclease activity
Synonym: phage-T4 UV endonuclease
Synonym: Phage-T(4) UV endonuclease activity
Synonym: Phage-T4 UV endonuclease activity
Synonym: X-ray endonuclease III
GO id:GO:0003906
Definition:Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
Number of paths to term: 3

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-ahydrolase activity
                                is-ahydrolase activity, acting on ester bonds
                                        is-anuclease activity
                                                is-adeoxyribonuclease activity
                                                        is-aendodeoxyribonuclease activity
                                                                is-aDNA-(apurinic or apyrimidinic site) lyase activity [GO:0003906] (13 genes, 21 annotations)
                                                                        is-aoxidized purine nucleobase lesion DNA N-glycosylase activity +
                                                                        is-aoxidized pyrimidine nucleobase lesion DNA N-glycosylase activity +
                                                                        is-apyrimidine dimer DNA N-glycosylase activity
                                                                is-adouble-stranded DNA endodeoxyribonuclease activity
                                                                is-aendodeoxyribonuclease activity, producing 3'-phosphomonoesters +
                                                                is-aendodeoxyribonuclease activity, producing 5'-phosphomonoesters +
                                                                is-aexcinuclease ABC activity
                                                                is-aflap endonuclease activity +
                                                                is-apyrimidine dimer DNA N-glycosylase activity
                                                                is-arestriction endodeoxyribonuclease activity +
                                                                is-aretroviral 3' processing activity
                                                                is-asingle-stranded DNA endodeoxyribonuclease activity
                                                                is-asite-specific endodeoxyribonuclease activity, specific for altered base +


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-ahydrolase activity
                                is-ahydrolase activity, acting on ester bonds
                                        is-anuclease activity
                                                is-aendonuclease activity
                                                        is-aendodeoxyribonuclease activity
                                                                is-aDNA-(apurinic or apyrimidinic site) lyase activity [GO:0003906] (13 genes, 21 annotations)
                                                                        is-aoxidized purine nucleobase lesion DNA N-glycosylase activity +
                                                                        is-aoxidized pyrimidine nucleobase lesion DNA N-glycosylase activity +
                                                                        is-apyrimidine dimer DNA N-glycosylase activity
                                                                is-adouble-stranded DNA endodeoxyribonuclease activity
                                                                is-aendodeoxyribonuclease activity, producing 3'-phosphomonoesters +
                                                                is-aendodeoxyribonuclease activity, producing 5'-phosphomonoesters +
                                                                is-aexcinuclease ABC activity
                                                                is-aflap endonuclease activity +
                                                                is-apyrimidine dimer DNA N-glycosylase activity
                                                                is-arestriction endodeoxyribonuclease activity +
                                                                is-aretroviral 3' processing activity
                                                                is-asingle-stranded DNA endodeoxyribonuclease activity
                                                                is-asite-specific endodeoxyribonuclease activity, specific for altered base +


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-alyase activity
                                is-acarbon-oxygen lyase activity
                                        is-a2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity
                                        is-a5'-deoxyribose-5-phosphate lyase activity
                                        is-acarbon-oxygen lyase activity, acting on phosphates +
                                        is-acarbon-oxygen lyase activity, acting on polysaccharides +
                                        is-acarboxymethyloxysuccinate lyase activity
                                        is-acysteine synthase activity
                                        is-aDNA-(apurinic or apyrimidinic site) lyase activity [GO:0003906] (13 genes, 21 annotations)
                                                is-aoxidized purine nucleobase lesion DNA N-glycosylase activity +
                                                is-aoxidized pyrimidine nucleobase lesion DNA N-glycosylase activity +
                                                is-apyrimidine dimer DNA N-glycosylase activity
                                        is-ahydro-lyase activity +
                                        is-aO-acetylhomoserine sulfhydrylase activity


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory