Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes APCS
  • Mouse genes Apcs
  • Rat genes Apcs
  • Zfish genes apcs,crp1,crp2,crp6,crp7
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Apcs

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	APCS	IDA		Human	PMID:23544079
Molecular Function	GO:0015485	cholesterol binding	crp7	IDA		Zfish	PMID:30653529
Molecular Function	GO:0015485	cholesterol binding	crp2	IDA		Zfish	PMID:30653529
Molecular Function	GO:0001849	complement component C1q complex binding	APCS	IDA		Human	PMID:23544079
Molecular Function	GO:0042802	identical protein binding	APCS	IPI	UniProtKB:P02743	Human	PMID:19372378
Molecular Function	GO:0042802	identical protein binding	APCS	IPI	UniProtKB:P02743	Human	PMID:22396542
Molecular Function	GO:0042802	identical protein binding	APCS	IPI	UniProtKB:P02743	Human	PMID:23850452
Molecular Function	GO:0008142	oxysterol binding	crp7	IDA		Zfish	PMID:30653529
Molecular Function	GO:0005515	protein binding	APCS	IPI	UniProtKB:P11226	Human	PMID:21106539
Molecular Function	GO:0005515	protein binding	APCS	IPI	UniProtKB:Q9Y5P4-1	Human	PMID:22396542
Molecular Function	GO:0005515	protein binding	APCS	IPI	UniProtKB:Q9Y5P4-2	Human	PMID:22396542
Molecular Function	GO:0005515	protein binding	APCS	IPI	UniProtKB:Q15699	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APCS	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0046790	virion binding	APCS	IDA		Human	PMID:23544079
Cellular Component	GO:0072562	blood microparticle	APCS	HDA		Human	PMID:22516433
Cellular Component	GO:0062023	collagen-containing extracellular matrix	APCS	HDA		Human	PMID:20551380
Cellular Component	GO:0062023	collagen-containing extracellular matrix	APCS	HDA		Human	PMID:27559042
Cellular Component	GO:0070062	extracellular exosome	APCS	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	APCS	HDA		Human	PMID:23533145
Cellular Component	GO:0005576	extracellular region	APCS	HDA		Human	PMID:27068509
Cellular Component	GO:0005615	extracellular space	APCS	IDA		Human	PMID:14607961
Cellular Component	GO:0005615	extracellular space	APCS	HDA		Human	PMID:20551380
Cellular Component	GO:0005615	extracellular space	APCS	IDA		Human	PMID:23544079
Cellular Component	GO:0005634	nucleus	APCS	HDA		Human	PMID:21630459
Cellular Component	GO:0032991	protein-containing complex	Apcs	IDA		Rat	PMID:12676928|RGD:1582508
Biological Process	GO:0051607	defense response to virus	crp6	IDA		Zfish	PMID:28915434
Biological Process	GO:0051607	defense response to virus	crp1	IDA		Zfish	PMID:28915434
Biological Process	GO:0051607	defense response to virus	crp7	IDA		Zfish	PMID:28915434
Biological Process	GO:0051607	defense response to virus	crp2	IDA		Zfish	PMID:28915434
Biological Process	GO:0045087	innate immune response	APCS	IDA		Human	PMID:23544079
Biological Process	GO:0044869	negative regulation by host of viral exo-alpha-sialidase activity	APCS	IDA		Human	PMID:23544079
Biological Process	GO:0044871	negative regulation by host of viral glycoprotein metabolic process	APCS	IDA		Human	PMID:23544079
Biological Process	GO:1903016	negative regulation of exo-alpha-sialidase activity	APCS	IDA		Human	PMID:23544079
Biological Process	GO:1903019	negative regulation of glycoprotein metabolic process	APCS	IDA		Human	PMID:23544079
Biological Process	GO:0045656	negative regulation of monocyte differentiation	APCS	IDA		Human	PMID:14607961
Biological Process	GO:0046597	negative regulation of viral entry into host cell	APCS	IDA		Human	PMID:23544079
Biological Process	GO:0048525	negative regulation of viral process	APCS	IDA		Human	PMID:23544079
Biological Process	GO:0065003	protein-containing complex assembly	Apcs	IPI	RGD:3088|RGD:2075|RGD:3305|RGD:708488|ChEBI:35156|ChEBI:26020	Rat	PMID:12676928|RGD:1582508
Biological Process	GO:0009617	response to bacterium	crp2	IDA		Zfish	PMID:16630661

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern