Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ANK2
  • Mouse genes Ank2
  • Rat genes Ank2
  • Zfish genes ank2a,ank2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ank2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051117	ATPase binding	Ank2	IPI	UniProtKB:Q6PIE5|UniProtKB:Q8VDN2	Mouse	MGI:MGI:3610760|PMID:16292983
Molecular Function	GO:0019899	enzyme binding	ANK2	IPI	UniProtKB:Q9NWT6	Human	PMID:21177872
Molecular Function	GO:0140031	phosphorylation-dependent protein binding	ANK2	IPI	UniProtKB:B3KU38	Human	PMID:25950943
Molecular Function	GO:0140031	phosphorylation-dependent protein binding	ANK2	IPI	UniProtKB:P0DPB3	Human	PMID:25950943
Molecular Function	GO:0015459	potassium channel regulator activity	Ank2	IMP	MGI:MGI:2179754	Mouse	PMID:20610380
Molecular Function	GO:0005515	protein binding	ANK2	IPI	UniProtKB:Q01082	Human	PMID:15262991
Molecular Function	GO:0005515	protein binding	ANK2	IPI	UniProtKB:Q9H310	Human	PMID:15611082
Molecular Function	GO:0005515	protein binding	ANK2	IPI	UniProtKB:P32418	Human	PMID:17178715
Molecular Function	GO:0005515	protein binding	ANK2	IPI	UniProtKB:P62993	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	ANK2	IPI	UniProtKB:P11532-5	Human	PMID:19109891
Molecular Function	GO:0005515	protein binding	ANK2	IPI	UniProtKB:Q14654	Human	PMID:19805355
Molecular Function	GO:0005515	protein binding	ANK2	IPI	UniProtKB:Q9NZN3	Human	PMID:20489164
Molecular Function	GO:0005515	protein binding	ANK2	IPI	UniProtKB:Q99246	Human	PMID:21859974
Molecular Function	GO:0005515	protein binding	ANK2	IPI	UniProtKB:O00154	Human	PMID:26949739
Molecular Function	GO:0005515	protein binding	Ank2	IPI	UniProtKB:Q61743	Mouse	MGI:MGI:4361760|PMID:19805355
Molecular Function	GO:0005515	protein binding	Ank2	IPI	PR:Q9EQP2	Mouse	PMID:20489164
Molecular Function	GO:0005515	protein binding	Ank2	IPI	PR:Q9QXY6	Mouse	PMID:20489164
Molecular Function	GO:0005515	protein binding	Ank2	IPI	PR:Q6PD03	Mouse	PMID:17416611
Molecular Function	GO:0005515	protein binding	Ank2	IPI	PR:P97952	Mouse	PMID:15272007
Molecular Function	GO:0005515	protein binding	Ank2	IPI	PR:Q62261	Mouse	PMID:15262991
Molecular Function	GO:0005515	protein binding	Ank2	IPI	PR:Q9WVK4	Mouse	PMID:20489164
Molecular Function	GO:0005515	protein binding	Ank2	IPI	PR:Q8BH64	Mouse	PMID:20489164
Molecular Function	GO:0005515	protein binding	Ank2	IPI	PR:Q61743	Mouse	PMID:20610380
Molecular Function	GO:0005515	protein binding	Ank2	IPI	RGD:3717	Rat	PMID:14593108|RGD:6767300
Molecular Function	GO:0019901	protein kinase binding	ANK2	IPI	UniProtKB:Q5VST9	Human	PMID:18782775
Molecular Function	GO:0019901	protein kinase binding	Ank2	IPI	UniProtKB:Q80ZF5	Rat	PMID:18782775|RGD:8554785
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	Ank2	IMP		Mouse	MGI:MGI:4844023|PMID:20610380
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	Ank2	IDA		Mouse	MGI:MGI:3610760|PMID:16292983
Molecular Function	GO:0030507	spectrin binding	ANK2	IPI	UniProtKB:Q01082	Human	PMID:15262991
Molecular Function	GO:0005200	structural constituent of cytoskeleton	Ank2	IDA		Rat	PMID:16687515|RGD:1599119
Molecular Function	GO:0044325	transmembrane transporter binding	ANK2	IPI	UniProtKB:Q14654	Human	PMID:20610380
Molecular Function	GO:0044325	transmembrane transporter binding	ANK2	IPI	UniProtKB:P27732	Human	PMID:21859974
Molecular Function	GO:0044325	transmembrane transporter binding	Ank2	IPI	UniProtKB:Q61743	Mouse	MGI:MGI:4844023|PMID:20610380
Molecular Function	GO:0044325	transmembrane transporter binding	Ank2	IPI	UniProtKB:P70414	Mouse	MGI:MGI:3610760|PMID:16292983
Molecular Function	GO:0044325	transmembrane transporter binding	Ank2	IPI	UniProtKB:P70673	Rat	PMID:19805355|RGD:8554464
Cellular Component	GO:0031672	A band	Ank2	IDA		Mouse	MGI:MGI:2176661|PMID:11781319
Cellular Component	GO:0031672	A band	Ank2	IDA		Mouse	MGI:MGI:3610760|PMID:16292983
Cellular Component	GO:0016323	basolateral plasma membrane	ANK2	IDA		Human	PMID:15611082
Cellular Component	GO:0043034	costamere	Ank2	IDA		Mouse	MGI:MGI:3610760|PMID:16292983
Cellular Component	GO:0005737	cytoplasm	Ank2	IDA		Mouse	PMID:15262991
Cellular Component	GO:0005856	cytoskeleton	Ank2	IDA		Rat	PMID:16687515|RGD:1599119
Cellular Component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	Ank2	IDA		Mouse	MGI:MGI:3835238|PMID:19007774
Cellular Component	GO:0014704	intercalated disc	Ank2	IDA		Mouse	MGI:MGI:2449848|PMID:12571597
Cellular Component	GO:0031430	M band	Ank2	IDA		Mouse	MGI:MGI:2449848|PMID:12571597
Cellular Component	GO:0031430	M band	Ank2	IDA		Mouse	MGI:MGI:3822951|PMID:18782775
Cellular Component	GO:0031430	M band	Ank2	IDA		Mouse	MGI:MGI:3056879|PMID:15262991
Cellular Component	GO:0031430	M band	Ank2	IMP		Mouse	MGI:MGI:5427070|PMID:21859974
Cellular Component	GO:0031430	M band	Ank2	IDA		Mouse	PMID:17416611
Cellular Component	GO:0045121	membrane raft	Ank2	IDA		Rat	PMID:16687515|RGD:1599119
Cellular Component	GO:0043005	neuron projection	Ank2	IDA		Rat	PMID:9202331|RGD:1599109
Cellular Component	GO:0033010	paranodal junction	Ank2	IDA		Mouse	PMID:16687515
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Ank2	IDA		Mouse	PMID:20489164
Cellular Component	GO:0005886	plasma membrane	ANK2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	Ank2	IMP		Mouse	MGI:MGI:5430886|PMID:18832177
Cellular Component	GO:0005886	plasma membrane	Ank2	IDA		Mouse	PMID:20489164
Cellular Component	GO:0005886	plasma membrane	Ank2	IDA		Rat	PMID:9202331|RGD:1599109
Cellular Component	GO:0014069	postsynaptic density	Ank2	IDA		Mouse	PMID:17114649
Cellular Component	GO:0042383	sarcolemma	Ank2	IMP		Mouse	MGI:MGI:5427070|PMID:21859974
Cellular Component	GO:0042383	sarcolemma	Ank2	IDA		Mouse	MGI:MGI:3610760|PMID:16292983
Cellular Component	GO:0030315	T-tubule	Ank2	IDA		Mouse	MGI:MGI:3610760|PMID:16292983
Cellular Component	GO:0030315	T-tubule	Ank2	IDA		Mouse	MGI:MGI:2449848|PMID:12571597
Cellular Component	GO:0030018	Z disc	Ank2	IDA		Mouse	MGI:MGI:3763979|PMID:17884088
Cellular Component	GO:0030018	Z disc	Ank2	IDA		Mouse	MGI:MGI:2176661|PMID:11781319
Cellular Component	GO:0030018	Z disc	Ank2	IDA		Mouse	MGI:MGI:2449848|PMID:12571597
Cellular Component	GO:0030018	Z disc	Ank2	IDA		Mouse	PMID:17416611
Biological Process	GO:0086014	atrial cardiac muscle cell action potential	ANK2	IMP		Human	PMID:17242276
Biological Process	GO:0086014	atrial cardiac muscle cell action potential	ANK2	IMP		Human	PMID:18832177
Biological Process	GO:0086014	atrial cardiac muscle cell action potential	ANK2	IMP		Human	PMID:21859974
Biological Process	GO:0086014	atrial cardiac muscle cell action potential	Ank2	IMP		Mouse	MGI:MGI:5427070|PMID:21859974
Biological Process	GO:0086066	atrial cardiac muscle cell to AV node cell communication	Ank2	IMP		Mouse	MGI:MGI:2449848|PMID:12571597
Biological Process	GO:0003283	atrial septum development	ANK2	IMP		Human	PMID:18832177
Biological Process	GO:0060048	cardiac muscle contraction	Ank2	IMP		Mouse	PMID:15262991
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Ank2	IMP		Mouse	MGI:MGI:5430886|PMID:18832177
Biological Process	GO:0007399	nervous system development	Ank2	IEP		Rat	PMID:9832159|RGD:1599117
Biological Process	GO:0030913	paranodal junction assembly	Ank2	IEP		Rat	PMID:16687515|RGD:1599119
Biological Process	GO:1901021	positive regulation of calcium ion transmembrane transporter activity	Ank2	IMP		Mouse	MGI:MGI:5430886|PMID:18832177
Biological Process	GO:0051928	positive regulation of calcium ion transport	Ank2	IMP		Mouse	MGI:MGI:5430886|PMID:18832177
Biological Process	GO:2001259	positive regulation of cation channel activity	Ank2	IMP		Mouse	MGI:MGI:4361760|PMID:19805355
Biological Process	GO:2001259	positive regulation of cation channel activity	Ank2	IMP		Mouse	MGI:MGI:4844023|PMID:20610380
Biological Process	GO:0010628	positive regulation of gene expression	ANK2	IGI	UniProtKB:Q8C8R3	Human	PMID:17242276
Biological Process	GO:0010628	positive regulation of gene expression	Ank2	IMP		Mouse	MGI:MGI:3771114|PMID:17242276
Biological Process	GO:0010628	positive regulation of gene expression	Ank2	IMP		Mouse	MGI:MGI:5430886|PMID:18832177
Biological Process	GO:1901018	positive regulation of potassium ion transmembrane transporter activity	Ank2	IMP		Mouse	MGI:MGI:4844023|PMID:20610380
Biological Process	GO:1901018	positive regulation of potassium ion transmembrane transporter activity	Ank2	IMP		Mouse	MGI:MGI:4361760|PMID:19805355
Biological Process	GO:0043268	positive regulation of potassium ion transport	Ank2	IMP		Mouse	MGI:MGI:4361760|PMID:19805355
Biological Process	GO:0043268	positive regulation of potassium ion transport	Ank2	IMP		Mouse	MGI:MGI:4844023|PMID:20610380
Biological Process	GO:0008104	protein localization	ANK2	IGI	UniProtKB:Q8C8R3	Human	PMID:15262991
Biological Process	GO:0008104	protein localization	ANK2	IGI	UniProtKB:Q8C8R3	Human	PMID:17242276
Biological Process	GO:0008104	protein localization	Ank2	IMP		Mouse	MGI:MGI:3771114|PMID:17242276
Biological Process	GO:0008104	protein localization	Ank2	IMP		Mouse	PMID:17416611
Biological Process	GO:0008104	protein localization	Ank2	IMP		Mouse	PMID:15262991
Biological Process	GO:0034394	protein localization to cell surface	Ank2	IMP		Mouse	MGI:MGI:3056879|PMID:15262991
Biological Process	GO:0070972	protein localization to endoplasmic reticulum	ANK2	IGI	UniProtKB:Q8C8R3	Human	PMID:15178757
Biological Process	GO:0070972	protein localization to endoplasmic reticulum	Ank2	IMP		Mouse	MGI:MGI:2176661|PMID:11781319
Biological Process	GO:0070972	protein localization to endoplasmic reticulum	Ank2	IMP		Mouse	MGI:MGI:3044878|PMID:15178757
Biological Process	GO:0036309	protein localization to M-band	Ank2	IMP		Mouse	MGI:MGI:3056879|PMID:15262991
Biological Process	GO:0036309	protein localization to M-band	Ank2	IMP		Mouse	MGI:MGI:3822951|PMID:18782775
Biological Process	GO:0033365	protein localization to organelle	ANK2	IGI	UniProtKB:Q8C8R3	Human	PMID:15178757
Biological Process	GO:0072659	protein localization to plasma membrane	ANK2	IGI	UniProtKB:Q8C8R3	Human	PMID:17178715
Biological Process	GO:0072659	protein localization to plasma membrane	Ank2	IMP		Mouse	MGI:MGI:4361760|PMID:19805355
Biological Process	GO:0072659	protein localization to plasma membrane	Ank2	IMP		Mouse	MGI:MGI:5427070|PMID:21859974
Biological Process	GO:0072659	protein localization to plasma membrane	Ank2	IMP		Mouse	MGI:MGI:5430886|PMID:18832177
Biological Process	GO:0072659	protein localization to plasma membrane	Ank2	IMP		Mouse	PMID:20489164
Biological Process	GO:0072659	protein localization to plasma membrane	Ank2	IGI	UniProtKB:Q9NZN3	Mouse	PMID:20489164
Biological Process	GO:0072659	protein localization to plasma membrane	Ank2	IMP	MGI:MGI:2179754	Mouse	PMID:20610380
Biological Process	GO:0036371	protein localization to T-tubule	Ank2	IMP		Mouse	MGI:MGI:3610760|PMID:16292983
Biological Process	GO:0050821	protein stabilization	Ank2	IMP		Mouse	MGI:MGI:5430893|PMID:17178715
Biological Process	GO:0098910	regulation of atrial cardiac muscle cell action potential	ANK2	IMP		Human	PMID:12571597
Biological Process	GO:0098910	regulation of atrial cardiac muscle cell action potential	Ank2	IMP		Mouse	MGI:MGI:2449848|PMID:12571597
Biological Process	GO:0098904	regulation of AV node cell action potential	Ank2	IMP		Mouse	MGI:MGI:2449848|PMID:12571597
Biological Process	GO:1901019	regulation of calcium ion transmembrane transporter activity	Ank2	IMP		Mouse	MGI:MGI:5427070|PMID:21859974
Biological Process	GO:0051924	regulation of calcium ion transport	ANK2	IGI	UniProtKB:Q8C8R3	Human	PMID:12571597
Biological Process	GO:0051924	regulation of calcium ion transport	ANK2	IGI	UniProtKB:Q8C8R3	Human	PMID:15178757
Biological Process	GO:0051924	regulation of calcium ion transport	Ank2	IMP		Mouse	MGI:MGI:2449848|PMID:12571597
Biological Process	GO:0051924	regulation of calcium ion transport	Ank2	IMP		Mouse	MGI:MGI:3044878|PMID:15178757
Biological Process	GO:0086004	regulation of cardiac muscle cell contraction	ANK2	IGI	UniProtKB:Q8C8R3	Human	PMID:17242276
Biological Process	GO:0086004	regulation of cardiac muscle cell contraction	Ank2	IMP		Mouse	MGI:MGI:3771114|PMID:17242276
Biological Process	GO:0086036	regulation of cardiac muscle cell membrane potential	Ank2	IGI	UniProtKB:Q9NZN3	Mouse	PMID:20489164
Biological Process	GO:0086036	regulation of cardiac muscle cell membrane potential	Ank2	IMP		Mouse	PMID:20489164
Biological Process	GO:0055117	regulation of cardiac muscle contraction	ANK2	IMP		Human	PMID:15178757
Biological Process	GO:0055117	regulation of cardiac muscle contraction	Ank2	IMP		Mouse	MGI:MGI:3044878|PMID:15178757
Biological Process	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling	ANK2	IMP		Human	PMID:12571597
Biological Process	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling	Ank2	IMP		Mouse	MGI:MGI:2449848|PMID:12571597
Biological Process	GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	ANK2	IGI	UniProtKB:Q8C8R3	Human	PMID:17178715
Biological Process	GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	Ank2	IMP		Mouse	MGI:MGI:5427070|PMID:21859974
Biological Process	GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	Ank2	IMP		Mouse	MGI:MGI:5430893|PMID:17178715
Biological Process	GO:2001257	regulation of cation channel activity	Ank2	IMP	MGI:MGI:2179754	Mouse	PMID:20610380
Biological Process	GO:0002027	regulation of heart rate	ANK2	IMP		Human	PMID:18832177
Biological Process	GO:0002027	regulation of heart rate	Ank2	IMP		Mouse	MGI:MGI:5430886|PMID:18832177
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	ANK2	IMP		Human	PMID:12571597
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	ANK2	IMP		Human	PMID:15178757
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	ANK2	IMP		Human	PMID:17242276
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	ANK2	IMP		Human	PMID:21859974
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	Ank2	IMP		Mouse	MGI:MGI:2176661|PMID:11781319
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	Ank2	IMP		Mouse	MGI:MGI:3044878|PMID:15178757
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	Ank2	IMP		Mouse	MGI:MGI:2449848|PMID:12571597
Biological Process	GO:0051279	regulation of release of sequestered calcium ion into cytosol	ANK2	IGI	UniProtKB:Q8C8R3	Human	PMID:17242276
Biological Process	GO:0098907	regulation of SA node cell action potential	ANK2	IMP		Human	PMID:12571597
Biological Process	GO:0098907	regulation of SA node cell action potential	ANK2	IMP		Human	PMID:18832177
Biological Process	GO:0098907	regulation of SA node cell action potential	Ank2	IMP		Mouse	MGI:MGI:2449848|PMID:12571597
Biological Process	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization	ANK2	IMP		Human	PMID:18832177
Biological Process	GO:0051597	response to methylmercury	Ank2	IEP		Rat	PMID:12949909|RGD:1599116
Biological Process	GO:0086015	SA node cell action potential	Ank2	IMP		Mouse	MGI:MGI:5430886|PMID:18832177
Biological Process	GO:0086070	SA node cell to atrial cardiac muscle cell communication	ANK2	IMP		Human	PMID:12571597
Biological Process	GO:0086070	SA node cell to atrial cardiac muscle cell communication	ANK2	IMP		Human	PMID:18832177
Biological Process	GO:0086070	SA node cell to atrial cardiac muscle cell communication	ANK2	IMP		Human	PMID:21859974
Biological Process	GO:0086070	SA node cell to atrial cardiac muscle cell communication	Ank2	IMP		Mouse	MGI:MGI:5430886|PMID:18832177
Biological Process	GO:0033292	T-tubule organization	Ank2	IMP		Mouse	MGI:MGI:3610760|PMID:16292983
Biological Process	GO:0033292	T-tubule organization	Ank2	IMP	MGI:MGI:2179754	Mouse	PMID:20610380
Biological Process	GO:0086005	ventricular cardiac muscle cell action potential	ANK2	IMP		Human	PMID:17242276

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern