Ank2
Gene Detail

Symbol Name ID

Ank2 ankyrin 2, brain MGI:88025

Synonyms

Ank-2, Ankyrin-2, ankyrin B, Ankyrin-B

Feature Type

protein coding gene

Genetic Map

Chromosome 3

56.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr3:126921607-126998452 bp, - strand From NCBI annotation of GRCm38   76846 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

Gene Tree: Ank2

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Homozygous mutation of this gene results in death by postnatal day 8, although some animals survive to P20. Mutant animals display reduced body size, impaired balance and locomotion, brain structure dysmorphologies, abnormal lens, and optic nerve degeneration.

 
Phenotype Images(5)

Gene Ontology (GO) classifications

All GO classifications: (72 annotations)

Process	apoptotic process, atrial cardiac muscle cell to AV node cell communication, ...
Component	A band, cell junction, ...
Function	ATPase binding, ion channel binding, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (45)    Tissues (35)    Images (10)
Theiler Stages: 15, 17, 19, 22, 23, 26, 28

Assay Type	Results
RNA in situ	32
RT-PCR	13

cDNA source data(20)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(22) cDNA(21) Primer pair(1)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000032826 (Evidence)
Entrez Gene	109676 (Evidence)
DFCI	TC1578300, TC1584408, TC1591980, TC1597280, TC1597806, TC1603015, TC1604160, TC1607343, TC1613433, TC1627089, TC1680089, TC1698674, TC1706804
DoTS	DT.101309119, DT.101709892, DT.101738671, DT.111066914, DT.111067001, DT.527983, DT.91335500, DT.91337939, DT.91347203, DT.91553351, DT.91584277, DT.97388946, DT.99842888
NIA Mouse Gene Index	U024623
Consensus CDS Project	CCDS38625.1
International Mouse Knockout Project Status	Ank2

Sequences

Length	Strain/Species
genomic	109676	NCBI Gene Model | MGI Sequence Detail	76846	C57BL/6J
transcript	NM_178655	RefSeq | MGI Sequence Detail	5790	C57BL/6
polypeptide	Q8C8R3	UniProt | EBI | MGI Sequence Detail	3898	Not Applicable

All sequences(62) RefSeq(4) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(638 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002110	Ankyrin repeat
InterPro	IPR020683	Ankyrin repeat-containing domain
InterPro	IPR000488	Death domain
InterPro	IPR011029	Death-like domain
InterPro	IPR000906	ZU5
Protein Ontology	PR:000004034	ankyrin-2

Graphical View of Protein Domain Structure

References

(Earliest) J:11441 Peters LL, et al., Purkinje cell degeneration associated with erythroid ankyrin deficiency in nb/nb mice. J Cell Biol. 1991 Sep;114(6):1233-41
(Latest) J:190418 Kashef F, et al., Ankyrin-B protein in heart failure: identification of a new component of metazoan cardioprotection. J Biol Chem. 2012 Aug 31;287(36):30268-81
All references(68)

Other accession IDs

MGD-MRK-1325, MGD-MRK-1328, MGI:2139799, MGI:2139987