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Ank2
Gene Detail
Symbol

Name
ID
Ank2
ankyrin 2, brain
MGI:88025
Synonyms
Ank-2, Ankyrin-2, ankyrin B, Ankyrin-B, Gm4392
Feature Type
protein coding gene
Genetic Map
Chromosome 3
56.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr3:126921612-127499350 bp, - strand
From VEGA annotation of GRCm38

  577739 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
Gene Tree: Ank2
Mutations,
alleles, and
phenotypes
All mutations/alleles(65) : Gene trapped(62) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in death by postnatal day 8, although some animals survive to P20. Mutant animals display reduced body size, impaired balance and locomotion, brain structure dysmorphologies, abnormal lens, and optic nerve degeneration.
 
Phenotype Images(5)
Interactions
Ank2 interacts with 411 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (77 annotations)
Process atrial cardiac muscle cell action potential, atrial cardiac muscle cell to AV node cell communication, ...
Component A band, cell, ...
Function ATPase binding, ion channel binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (45)    Tissues (36)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 32
RT-PCR 13
cDNA source data(21)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase ank2 ; ZFIN ank2b    NEW 
Molecular
reagents
All nucleic(23) cDNA(22) Primer pair(1)
Microarray probesets(5)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043348 VEGA Gene Model | MGI Sequence Detail 577739 C57BL/6J ±  kb
transcript OTTMUST00000133378 VEGA | MGI Sequence Detail 5120 Not Applicable 
polypeptide OTTMUSP00000070958 VEGA | MGI Sequence Detail 1620 Not Applicable 

For the selected sequences
All sequences(254) RefSeq(74) UniProt(24)
Polymorphisms
RFLP(1) : SNPs within 2kb(8293 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR030301 Ankyrin-B
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR000488 Death domain
InterPro IPR011029 Death-like domain
InterPro IPR000906 ZU5 domain
Protein Ontology PR:000004034 ankyrin-2
References
(Earliest) J:11441 Peters LL, et al., Purkinje cell degeneration associated with erythroid ankyrin deficiency in nb/nb mice. J Cell Biol. 1991 Sep;114(6):1233-41
(Latest) J:222913 Lorenzo DN, et al., Ankyrin-B metabolic syndrome combines age-dependent adiposity with pancreatic beta cell insufficiency. J Clin Invest. 2015 Aug 3;125(8):3087-3102
All references(78)
Other
accession IDs
MGD-MRK-1325, MGD-MRK-1328, MGI:2139799, MGI:2139987, MGI:3782577

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory