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Ank2
Gene Detail
 Symbol
Name
ID
Ank2
ankyrin 2, brain
MGI:88025
Synonyms Ank-2, Ankyrin-2, ankyrin B, Ankyrin-B, Gm4392
Feature Type protein coding gene
Genetic Map
Chromosome 3
56.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr3:126921606-127499259 bp, - strand
From VEGA annotation of GRCm38

  577654 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
Gene Tree: Ank2
Alleles
and
phenotypes
All alleles(63) : Gene trapped(62) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in death by postnatal day 8, although some animals survive to P20. Mutant animals display reduced body size, impaired balance and locomotion, brain structure dysmorphologies, abnormal lens, and optic nerve degeneration.
 
Phenotype Images(5)
Gene Ontology
(GO)
classifications
All GO classifications: (73 annotations)
Process atrial cardiac muscle cell action potential, atrial cardiac muscle cell to AV node cell communication, ...
Component A band, cell, ...
Function ATPase binding, ion channel binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (45)    Tissues (35)    Images (10)
Theiler Stages: 15, 17, 19, 22, 23, 26, 28
Assay TypeResults
RNA in situ 32
RT-PCR 13
cDNA source data(20)
External Resources: Allen Institute   ArrayExpress
Molecular
reagents
All nucleic(22) cDNA(21) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000043348 (Evidence)
Ensembl Gene ModelENSMUSG00000032826 (Evidence)
Entrez Gene100043364, 109676
DFCITC1584408, TC1591980, TC1597280, TC1597806, TC1603015, TC1604160, TC1607343, TC1613433, TC1627089, TC1680089, TC1698674, TC1706804
DoTSDT.527983, DT.101309119, DT.101709892, DT.101738671, DT.111066914, DT.111067001, DT.91335500, DT.91337939, DT.91347203, DT.91553351, DT.91584277, DT.97388946, DT.99842888
NIA Mouse Gene IndexU024623
Consensus CDS ProjectCCDS38625.1
International Mouse Knockout Project StatusAnk2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043348 VEGA Gene Model | MGI Sequence Detail 577654 C57BL/6J ±  kb
transcript OTTMUST00000113760 VEGA | MGI Sequence Detail 13514 Not Applicable 
polypeptide OTTMUSP00000063564 VEGA | MGI Sequence Detail 3954 Not Applicable 

For the selected sequences
All sequences(189) UniProt(23)
Polymorphisms RFLP(1) : SNPs within 2kb(8290 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR000488 Death domain
InterPro IPR011029 Death-like domain
InterPro IPR000906 ZU5
Protein Ontology PR:000004034 ankyrin-2
References (Earliest) J:11441 Peters LL, et al., Purkinje cell degeneration associated with erythroid ankyrin deficiency in nb/nb mice. J Cell Biol. 1991 Sep;114(6):1233-41
(Latest) J:196688 Wolf RM, et al., Atrial fibrillation and sinus node dysfunction in human ankyrin-B syndrome: a computational analysis. Am J Physiol Heart Circ Physiol. 2013 May;304(9):H1253-66
All references(75)
Other
accession IDs
MGD-MRK-1325, MGD-MRK-1328, MGI:2139799, MGI:2139987, MGI:3782577

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory