Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ANGPT2
  • Mouse genes Angpt2
  • Rat genes Angpt2
  • Zfish genes angpt2a,angpt2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Angpt2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	ANGPT2	IPI	UniProtKB:Q02763	Human	PMID:20708158
Molecular Function	GO:0005515	protein binding	Angpt2	IPI	PR:Q02858	Mouse	PMID:9204896
Molecular Function	GO:0005515	protein binding	Angpt2	IPI	PR:A2AVA0	Mouse	PMID:28179430
Molecular Function	GO:0030971	receptor tyrosine kinase binding	ANGPT2	IPI	UniProtKB:Q02763	Human	PMID:19922791
Cellular Component	GO:0042995	cell projection	Angpt2	IDA		Rat	PMID:18272601|RGD:2314193
Cellular Component	GO:0005615	extracellular space	ANGPT2	IDA		Human	PMID:9660821
Cellular Component	GO:0005615	extracellular space	Angpt2	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Cellular Component	GO:0005615	extracellular space	Angpt2	IDA		Rat	PMID:16628643|RGD:2314213
Cellular Component	GO:0005634	nucleus	Angpt2	IDA		Rat	PMID:18272601|RGD:2314193
Cellular Component	GO:0005886	plasma membrane	Angpt2	IDA		Rat	PMID:18272601|RGD:2314193
Biological Process	GO:0001525	angiogenesis	Angpt2	IGI	MGI:MGI:103178	Mouse	PMID:16778080
Biological Process	GO:0001525	angiogenesis	Angpt2	IEP		Rat	PMID:16439712|RGD:2314218
Biological Process	GO:0031100	animal organ regeneration	Angpt2	IEP		Rat	PMID:16437624|RGD:1626165
Biological Process	GO:0001568	blood vessel development	angpt2b	IGI	ZFIN:ZDB-GENO-100622-10,ZFIN:ZDB-MRPHLNO-100609-3	Zfish	PMID:20156556
Biological Process	GO:0048514	blood vessel morphogenesis	Angpt2	IMP	MGI:MGI:3040929	Mouse	PMID:15579434
Biological Process	GO:0071363	cellular response to growth factor stimulus	Angpt2	IEP		Rat	PMID:16176970|RGD:2314221
Biological Process	GO:0010467	gene expression	ANGPT2	IDA		Human	PMID:28179430
Biological Process	GO:0007281	germ cell development	Angpt2	IEP		Rat	PMID:18996974|RGD:2314172
Biological Process	GO:0072012	glomerulus vasculature development	Angpt2	IMP		Rat	PMID:20056745|RGD:8554659
Biological Process	GO:0060135	maternal process involved in female pregnancy	Angpt2	IEP		Rat	PMID:16452728|RGD:2314217
Biological Process	GO:0016525	negative regulation of angiogenesis	Angpt2	IDA		Mouse	PMID:9204896
Biological Process	GO:0043537	negative regulation of blood vessel endothelial cell migration	ANGPT2	IDA		Human	PMID:9660821
Biological Process	GO:0010812	negative regulation of cell-substrate adhesion	Angpt2	IDA		Mouse	PMID:9846489
Biological Process	GO:0050928	negative regulation of positive chemotaxis	ANGPT2	IDA		Human	PMID:9660821
Biological Process	GO:0045766	positive regulation of angiogenesis	Angpt2	IMP		Rat	PMID:15542434|RGD:2314235
Biological Process	GO:0014823	response to activity	Angpt2	IEP		Rat	PMID:18342145|RGD:2314190
Biological Process	GO:0009749	response to glucose	Angpt2	IEP		Rat	PMID:15048134|RGD:2314240
Biological Process	GO:0001666	response to hypoxia	Angpt2	IEP		Rat	PMID:17943991|RGD:2314202
Biological Process	GO:0009612	response to mechanical stimulus	Angpt2	IEP		Rat	PMID:19012730|RGD:8662390
Biological Process	GO:0014070	response to organic cyclic compound	Angpt2	IEP		Rat	PMID:19672036|RGD:2313934
Biological Process	GO:0009314	response to radiation	Angpt2	IEP		Rat	PMID:15208265|RGD:2314237
Biological Process	GO:0048014	Tie signaling pathway	ANGPT2	IDA		Human	PMID:19922791
Biological Process	GO:0001944	vasculature development	angpt2b	IMP	ZFIN:ZDB-MRPHLNO-100609-4	Zfish	PMID:25147335

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern