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Angpt2 Gene Detail
Summary
  • Symbol
    Angpt2
  • Name
    angiopoietin 2
  • Synonyms
    Ang2, Ang-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202890
    NCBI Gene: 11601
  • Gene Overview
    MyGene.info: ANGPT2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr8:18690263-18741562 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      51300 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 10.30 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ANGPT2, angiopoietin 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ANGPT2, angiopoietin 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AGPT2, ANG2
  • Links
    NCBI Gene ID: 285
    neXtProt AC: NX_O15123
    UniProt: O15123

  • Chr Location
    8p23.1; chr8:6499651-6563420 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 22401
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ANGPT2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 2 alleles in 1 genetic background
    15 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene results in impaired angiogenesis, abnormal lymphatic development and function, and ultimately postnatal lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000036075 VEGA Gene Model | MGI Sequence Detail 51300 C57BL/6J ±  kb
    transcript OTTMUST00000092685 VEGA | MGI Sequence Detail 3560 Not Applicable  
    polypeptide OTTMUSP00000051287 VEGA | MGI Sequence Detail 496 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      69 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000004024 angiopoietin-2
    • InterPro Domains
      IPR028844 Angiopoietin-2
      IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
      IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
      IPR014715 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
      IPR020837 Fibrinogen, conserved site
      IPR036056 Fibrinogen-like, C-terminal
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 32
      Primer pair 8
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 156
      Developmental Gene Expression 77
      Gene Ontology 11
      Phenotypes 23
    • Earliest
      J:4639 Fujisawa-Sehara A, et al., Upstream region of the myogenin gene confers transcriptional activation in muscle cell lineages during mouse embryogenesis. Biochem Biophys Res Commun. 1993 Mar 15;191(2):351-6
    • Latest
      J:258670 Mahany EB, et al., Obesity and High-Fat Diet Induce Distinct Changes in Placental Gene Expression and Pregnancy Outcome. Endocrinology. 2018 Apr 1;159(4):1718-1733

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory