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Angpt2
Gene Detail
 Symbol
Name
ID
Angpt2
angiopoietin 2
MGI:1202890
Synonyms Ang2, Ang-2
Feature Type protein coding gene
Genetic Map
Chromosome 8
10.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:18690263-18741562 bp, - strand
From VEGA annotation of GRCm38

  51300 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22401  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Angpt2

Human
homologs
Human Homolog ANGPT2, angiopoietin 2
NCBI Gene ID 285
neXtProt AC  NX_O15123
Human Synonyms  AGPT2, ANG2
Human Chr (Location)  8p23.1; chr8:6499651-6563263 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene results in impaired angiogenesis, abnormal lymphatic development and function, and ultimately postnatal lethality.
 
Interactions
Angpt2 interacts with 250 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process angiogenesis, blood vessel morphogenesis, ...
Component cell projection, extracellular region, ...
Function metal ion binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (63 records)
Data Summary: Results (178)    Tissues (122)    Images (40)
Theiler Stages: 14, 17, 19, 20, 21, 22, 23, 24, 25, 27, 28
Assay TypeResults
RNA in situ 127
Northern blot 3
Western blot 4
RT-PCR 44
cDNA source data(30)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(39) cDNA(31) Primer pair(7) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000036075 (Evidence)
Ensembl Gene ModelENSMUSG00000031465 (Evidence)
Entrez Gene11601 (Evidence)
UniGene439874
DFCITC1582239, TC1594076, TC1677999
DoTSDT.528366
NIA Mouse Gene IndexU029620
Consensus CDS ProjectCCDS22125.1
International Mouse Knockout Project StatusAngpt2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036075 VEGA Gene Model | MGI Sequence Detail 51300 C57BL/6J ±  kb
transcript OTTMUST00000092685 VEGA | MGI Sequence Detail 3560 Not Applicable 
polypeptide OTTMUSP00000051287 VEGA | MGI Sequence Detail 496 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(70 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
InterPro IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
InterPro IPR014715 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
InterPro IPR020837 Fibrinogen, conserved site
Protein Ontology PR:000004024 angiopoietin-2
References (Earliest) J:4639 Fujisawa-Sehara A, et al., Upstream region of the myogenin gene confers transcriptional activation in muscle cell lineages during mouse embryogenesis. Biochem Biophys Res Commun. 1993 Mar 15;191(2):351-6
(Latest) J:207486 Hu J, et al., Endothelial cell-derived angiopoietin-2 controls liver regeneration as a spatiotemporal rheostat. Science. 2014 Jan 24;343(6169):416-9
All references(115)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory