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Angpt2
Gene Detail
Symbol

Name
ID
Angpt2
angiopoietin 2
MGI:1202890
Synonyms
Ang2, Ang-2
Feature Type
protein coding gene
Genetic Map
Chromosome 8
10.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:18690263-18741562 bp, - strand
From VEGA annotation of GRCm38

  51300 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22401  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ANGPT2
Gene Tree: Angpt2

Human
homologs
ANGPT2, angiopoietin 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 285
neXtProt AC: NX_O15123

Human Synonyms: AGPT2, ANG2

Human Chr (Location): 8p23.1; chr8:6499651-6563263 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene results in impaired angiogenesis, abnormal lymphatic development and function, and ultimately postnatal lethality.
 
Interactions
Angpt2 interacts with 250 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process angiogenesis, blood vessel morphogenesis, ...
Component cell projection, extracellular region, ...
Function metal ion binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (64 records)
Data Summary: Results (178)    Tissues (122)    Images (40)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 127
Northern blot 3
Western blot 4
RT-PCR 44
cDNA source data(30)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA ANGPT2 ; Xenbase angpt2 ; ZFIN angpt2b    NEW 
Molecular
reagents
All nucleic(39) cDNA(31) Primer pair(7) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000036075 (Evidence)
Ensembl Gene Model ENSMUSG00000031465 (Evidence)
Entrez Gene 11601 (Evidence)
UniGene 439874
DFCI TC1677999, TC1594076, TC1582239
DoTS DT.528366
NIA Mouse Gene Index U029620
Consensus CDS Project CCDS22125.1
International Mouse Phenotyping Consortium Status Angpt2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036075 VEGA Gene Model | MGI Sequence Detail 51300 C57BL/6J ±  kb
transcript OTTMUST00000092685 VEGA | MGI Sequence Detail 3560 Not Applicable 
polypeptide OTTMUSP00000051287 VEGA | MGI Sequence Detail 496 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(70 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
InterPro IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
InterPro IPR014715 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
InterPro IPR020837 Fibrinogen, conserved site
Protein Ontology PR:000004024 angiopoietin-2
References
(Earliest) J:4639 Fujisawa-Sehara A, et al., Upstream region of the myogenin gene confers transcriptional activation in muscle cell lineages during mouse embryogenesis. Biochem Biophys Res Commun. 1993 Mar 15;191(2):351-6
(Latest) J:217497 Morioka T, et al., An important role of endothelial hairy-related transcription factors in mouse vascular development. Genesis. 2014 Nov;52(11):897-906
All references(118)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory