About   Help   FAQ
Angpt2 Gene Detail
Summary
  • Symbol
    Angpt2
  • Name
    angiopoietin 2
  • Synonyms
    Ang2, Ang-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202890
    NCBI Gene: 11601
  • Gene Overview
    MyGene.info: ANGPT2
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:18690263-18741562 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 10.30 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    69 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1202890
protein coding gene Chr8:18690263-18741562 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033404
protein coding gene Chr8:16155893-16210705 (-)
A/J MGP_AJ_G0033385
protein coding gene Chr8:15599228-15650480 (-)
AKR/J MGP_AKRJ_G0033315
protein coding gene Chr8:16052360-16106053 (-)
BALB/cJ MGP_BALBcJ_G0033385
protein coding gene Chr8:15708474-15764290 (-)
C3H/HeJ MGP_C3HHeJ_G0033098
protein coding gene Chr8:16248675-16301453 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033897
protein coding gene Chr8:16693101-16746092 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030863
protein coding gene Chr8:14915535-14965825 (-)
CAST/EiJ MGP_CASTEiJ_G0032420
protein coding gene Chr8:16099283-16152419 (-)
CBA/J MGP_CBAJ_G0033071
protein coding gene Chr8:17404424-17463398 (-)
DBA/2J MGP_DBA2J_G0033225
protein coding gene Chr8:15557555-15608649 (-)
FVB/NJ MGP_FVBNJ_G0033173
protein coding gene Chr8:15565430-15617049 (-)
LP/J MGP_LPJ_G0033318
protein coding gene Chr8:16178543-16233763 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033210
protein coding gene Chr8:17573677-17629245 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033914
protein coding gene Chr8:16078119-16130023 (-)
PWK/PhJ MGP_PWKPhJ_G0032133
protein coding gene Chr8:15575275-15627558 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031974
protein coding gene Chr8:16000590-16051262 (-)
WSB/EiJ MGP_WSBEiJ_G0032536
protein coding gene Chr8:16162529-16215871 (-)



Homology
more
  • Human Ortholog
    ANGPT2, angiopoietin 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ANGPT2, angiopoietin 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AGPT2, ANG2
  • Links
    NCBI Gene ID: 285
    neXtProt AC: NX_O15123
    UniProt: O15123

  • Chr Location
    8p23.1; chr8:6499651-6563420 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 22401
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ANGPT2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 1 genetic background
    15 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene results in impaired angiogenesis, abnormal lymphatic development and function, and ultimately postnatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11601 NCBI Gene Model | MGI Sequence Detail 51300 C57BL/6J ±  kb
    transcript NM_007426 RefSeq | MGI Sequence Detail 3560 C57BL/6  
    polypeptide O35608 UniProt | EBI | MGI Sequence Detail 496 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000004024 angiopoietin-2
    • InterPro Domains
      IPR028844 Angiopoietin-2
      IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
      IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
      IPR014715 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
      IPR020837 Fibrinogen, conserved site
      IPR036056 Fibrinogen-like, C-terminal
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 32
      Primer pair 8
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 155
      Developmental Gene Expression 77
      Gene Ontology 11
      Phenotypes 23
    • Earliest
      J:4639 Fujisawa-Sehara A, et al., Upstream region of the myogenin gene confers transcriptional activation in muscle cell lineages during mouse embryogenesis. Biochem Biophys Res Commun. 1993 Mar 15;191(2):351-6
    • Latest
      J:258670 Mahany EB, et al., Obesity and High-Fat Diet Induce Distinct Changes in Placental Gene Expression and Pregnancy Outcome. Endocrinology. 2018 Apr 1;159(4):1718-1733

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory