Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ALX4
  • Mouse genes Alx4
  • Rat genes Alx4
  • Zfish genes alx4a,alx4b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Alx4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Alx4	IDA		Mouse	MGI:MGI:1314705|PMID:9847249
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Alx4	IDA		Mouse	PMID:9847249
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Alx4	IDA		Mouse	PMID:11696550
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Alx4	IDA		Mouse	PMID:9786416
Molecular Function	GO:0071837	HMG box domain binding	Alx4	IPI	UniProtKB:O55170	Mouse	MGI:MGI:5284787|PMID:16582099
Molecular Function	GO:0005515	protein binding	ALX4	IPI	UniProtKB:Q8NA54	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALX4	IPI	UniProtKB:Q9HBI0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Alx4	IPI	PR:Q8C8B0	Mouse	PMID:9847249
Molecular Function	GO:0005515	protein binding	Alx4	IPI	UniProtKB:Q08999	Mouse	PMID:9786416
Molecular Function	GO:0005515	protein binding	Alx4	IPI	PR:P27782	Mouse	PMID:11696550
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Alx4	IDA		Mouse	MGI:MGI:1314705|PMID:9847249
Molecular Function	GO:0043565	sequence-specific DNA binding	Alx4	IDA		Mouse	PMID:9786416
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ALX4	IDA		Human	PMID:28473536
Cellular Component	GO:0005654	nucleoplasm	ALX4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	ALX4	IDA		Human	PMID:19692347
Cellular Component	GO:0005634	nucleus	Alx4	IDA		Mouse	PMID:9374397
Cellular Component	GO:0005634	nucleus	Alx4	IDA		Mouse	PMID:9786416
Cellular Component	GO:0005667	transcription regulator complex	Alx4	IPI	PR:P27782	Mouse	PMID:11696550
Cellular Component	GO:0005667	transcription regulator complex	Alx4	IDA		Mouse	PMID:9847249
Biological Process	GO:0009952	anterior/posterior pattern specification	Alx4	IGI	MGI:MGI:104621	Mouse	PMID:9847249
Biological Process	GO:0009952	anterior/posterior pattern specification	Alx4	IMP	MGI:MGI:1857484	Mouse	PMID:9374397
Biological Process	GO:0009952	anterior/posterior pattern specification	Alx4	IMP	MGI:MGI:1857484	Mouse	PMID:9847249
Biological Process	GO:0048565	digestive tract development	Alx4	IMP	MGI:MGI:1857484	Mouse	PMID:9268572
Biological Process	GO:0042733	embryonic digit morphogenesis	Alx4	IGI	MGI:MGI:88180	Mouse	PMID:9272948
Biological Process	GO:0042733	embryonic digit morphogenesis	Alx4	IMP	MGI:MGI:1857484	Mouse	PMID:9268572
Biological Process	GO:0035115	embryonic forelimb morphogenesis	Alx4	IGI	MGI:MGI:1277097	Mouse	PMID:11641221
Biological Process	GO:0035116	embryonic hindlimb morphogenesis	Alx4	IGI	MGI:MGI:1277097	Mouse	PMID:11641221
Biological Process	GO:0048704	embryonic skeletal system morphogenesis	Alx4	IMP	MGI:MGI:1856069	Mouse	PMID:15728667
Biological Process	GO:0048704	embryonic skeletal system morphogenesis	Alx4	IGI	MGI:MGI:1277097	Mouse	PMID:11641221
Biological Process	GO:0048704	embryonic skeletal system morphogenesis	Alx4	IGI	MGI:MGI:104621	Mouse	PMID:9847249
Biological Process	GO:0048704	embryonic skeletal system morphogenesis	Alx4	IGI	MGI:MGI:104621	Mouse	PMID:15728667
Biological Process	GO:0048704	embryonic skeletal system morphogenesis	Alx4	IGI	MGI:MGI:1277097	Mouse	PMID:15728667
Biological Process	GO:0001942	hair follicle development	ALX4	IMP		Human	PMID:19692347
Biological Process	GO:0035108	limb morphogenesis	Alx4	IMP	MGI:MGI:1857484	Mouse	PMID:9847249
Biological Process	GO:0035108	limb morphogenesis	Alx4	IMP	MGI:MGI:1857484	Mouse	PMID:9374397
Biological Process	GO:0035108	limb morphogenesis	Alx4	IGI	MGI:MGI:104621	Mouse	PMID:9847249
Biological Process	GO:0007517	muscle organ development	Alx4	IMP	MGI:MGI:1857484	Mouse	PMID:9374397
Biological Process	GO:0007389	pattern specification process	Alx4	IGI	MGI:MGI:1277097	Mouse	PMID:11641221
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Alx4	IGI	MGI:MGI:104621	Mouse	PMID:9847249
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Alx4	IDA		Mouse	PMID:9847249
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Alx4	IDA		Mouse	PMID:9786416
Biological Process	GO:0009791	post-embryonic development	Alx4	IMP	MGI:MGI:1857484	Mouse	PMID:9268572
Biological Process	GO:0042981	regulation of apoptotic process	Alx4	IGI	MGI:MGI:1277097	Mouse	PMID:11641221
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Alx4	IDA		Mouse	PMID:11696550
Biological Process	GO:0060021	roof of mouth development	Alx4	IGI	MGI:MGI:104621	Mouse	PMID:9847249
Biological Process	GO:0048705	skeletal system morphogenesis	Alx4	IMP	MGI:MGI:1857484	Mouse	PMID:9374397

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern