Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ALX1
  • Mouse genes Alx1
  • Rat genes Alx1
  • Zfish genes alx1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Alx1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ALX1	IDA		Human	PMID:9753625
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Alx1	IDA		Mouse	PMID:9847249
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Alx1	IDA		Rat	PMID:12390248|RGD:10047318
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Alx1	IMP		Rat	PMID:12929931|RGD:1358475
Molecular Function	GO:0005515	protein binding	ALX1	IPI	UniProtKB:O94829	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	ALX1	IPI	UniProtKB:O95833	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALX1	IPI	UniProtKB:P02743	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALX1	IPI	UniProtKB:P07492	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALX1	IPI	UniProtKB:P10276	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALX1	IPI	UniProtKB:P29692-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALX1	IPI	UniProtKB:Q8IUH3-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALX1	IPI	UniProtKB:Q8N7B6-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALX1	IPI	UniProtKB:Q8NGH7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALX1	IPI	UniProtKB:Q92993	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALX1	IPI	UniProtKB:Q96N76	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALX1	IPI	UniProtKB:Q96RE9-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALX1	IPI	UniProtKB:Q9BYR3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Alx1	IPI	UniProtKB:Q09472	Mouse	MGI:MGI:4835153|PMID:12929931
Molecular Function	GO:0005515	protein binding	Alx1	IPI	PR:O35137	Mouse	PMID:9847249
Molecular Function	GO:0042803	protein homodimerization activity	Alx1	IDA		Rat	PMID:12390248|RGD:10047318
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ALX1	IDA		Human	PMID:9753625
Molecular Function	GO:0043565	sequence-specific DNA binding	Alx1	IDA		Mouse	PMID:9847249
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ALX1	IDA		Human	PMID:28473536
Cellular Component	GO:0005794	Golgi apparatus	ALX1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016604	nuclear body	ALX1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	ALX1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	ALX1	IDA		Human	PMID:23288509
Cellular Component	GO:0005634	nucleus	ALX1	IDA		Human	PMID:9753625
Cellular Component	GO:0005634	nucleus	Alx1	IDA		Mouse	MGI:MGI:4835153|PMID:12929931
Cellular Component	GO:0005634	nucleus	Alx1	IDA		Rat	PMID:12390248|RGD:10047318
Cellular Component	GO:0005634	nucleus	Alx1	IDA		Rat	PMID:12929931|RGD:1358475
Cellular Component	GO:0005667	transcription regulator complex	Alx1	IDA		Mouse	PMID:9847249
Biological Process	GO:0009952	anterior/posterior pattern specification	Alx1	IGI	MGI:MGI:108359	Mouse	PMID:9847249
Biological Process	GO:0048593	camera-type eye morphogenesis	alx1	IMP	ZFIN:ZDB-GENO-221004-4	Zfish	PMID:35142342
Biological Process	GO:0048593	camera-type eye morphogenesis	alx1	IGI	ZFIN:ZDB-GENO-221004-5	Zfish	PMID:35142342
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	alx1	IMP	ZFIN:ZDB-MRPHLNO-130227-1	Zfish	PMID:23059813
Biological Process	GO:0030326	embryonic limb morphogenesis	Alx1	IGI	MGI:MGI:108359	Mouse	PMID:9847249
Biological Process	GO:0048702	embryonic neurocranium morphogenesis	alx1	IMP	ZFIN:ZDB-GENO-221004-4	Zfish	PMID:35142342
Biological Process	GO:0048702	embryonic neurocranium morphogenesis	alx1	IGI	ZFIN:ZDB-GENO-221004-5	Zfish	PMID:35142342
Biological Process	GO:0048704	embryonic skeletal system morphogenesis	Alx1	IGI	MGI:MGI:108359	Mouse	PMID:9847249
Biological Process	GO:0048704	embryonic skeletal system morphogenesis	Alx1	IGI	MGI:MGI:108359	Mouse	PMID:15728667
Biological Process	GO:0014031	mesenchymal cell development	Alx1	IMP	MGI:MGI:1857553	Mouse	PMID:8673125
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Alx1	IMP		Rat	PMID:12390248|RGD:10047318
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ALX1	IDA		Human	PMID:8756334
Biological Process	GO:0001755	neural crest cell migration	alx1	IGI	ZFIN:ZDB-GENO-221004-4,ZFIN:ZDB-CRISPR-221003-1	Zfish	PMID:35142342
Biological Process	GO:0001755	neural crest cell migration	alx1	IMP	ZFIN:ZDB-MRPHLNO-130227-1	Zfish	PMID:23059813
Biological Process	GO:0001843	neural tube closure	Alx1	IMP	MGI:MGI:1857553	Mouse	PMID:8673125
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ALX1	IMP		Human	PMID:23288509
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ALX1	IDA		Human	PMID:9753625
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Alx1	IMP		Rat	PMID:12390248|RGD:10047318
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Alx1	IDA		Rat	PMID:12929931|RGD:1358475
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	ALX1	IMP		Human	PMID:23288509
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ALX1	IDA		Human	PMID:9753625
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Alx1	IDA		Mouse	PMID:9847249
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Alx1	IGI	MGI:MGI:108359	Mouse	PMID:9847249
Biological Process	GO:0060021	roof of mouth development	Alx1	IGI	MGI:MGI:108359	Mouse	PMID:9847249
Biological Process	GO:0048864	stem cell development	Alx1	IMP	MGI:MGI:1857553	Mouse	PMID:8673125

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern