Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Alox5

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes ALOX5
- Mouse genes Alox5
- Rat genes Alox5
- Zfish genes alox5a
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Alox5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004051	arachidonate 5-lipoxygenase activity	ALOX5	IDA		Human	PMID:19022417
Molecular Function	GO:0004051	arachidonate 5-lipoxygenase activity	ALOX5	IDA		Human	PMID:21233389
Molecular Function	GO:0004051	arachidonate 5-lipoxygenase activity	ALOX5	IDA		Human	PMID:22516296
Molecular Function	GO:0004051	arachidonate 5-lipoxygenase activity	ALOX5	IDA		Human	PMID:23246375
Molecular Function	GO:0004051	arachidonate 5-lipoxygenase activity	ALOX5	IDA		Human	PMID:24282679
Molecular Function	GO:0004051	arachidonate 5-lipoxygenase activity	ALOX5	IDA		Human	PMID:24893149
Molecular Function	GO:0004051	arachidonate 5-lipoxygenase activity	ALOX5	IDA		Human	PMID:8615788
Molecular Function	GO:0004051	arachidonate 5-lipoxygenase activity	ALOX5	IDA		Human	PMID:8631361
Molecular Function	GO:0004051	arachidonate 5-lipoxygenase activity	Alox5	IMP		Mouse	MGI:MGI:6392995\|PMID:31642348
Molecular Function	GO:0004051	arachidonate 5-lipoxygenase activity	Alox5	IDA		Mouse	MGI:MGI:5551713\|PMID:23246375
Molecular Function	GO:0004051	arachidonate 5-lipoxygenase activity	alox5a	IDA		Zfish	PMID:26456699
Molecular Function	GO:0008391	arachidonic acid monooxygenase activity	alox5a	IDA		Zfish	PMID:25025884
Molecular Function	GO:0005506	iron ion binding	ALOX5	IDA		Human	PMID:21233389
Molecular Function	GO:0004464	leukotriene-C4 synthase activity	alox5a	IDA		Zfish	PMID:26456699
Molecular Function	GO:0005515	protein binding	ALOX5	IPI	UniProtKB:Q14019	Human	PMID:11297527
Molecular Function	GO:0005515	protein binding	ALOX5	IPI	UniProtKB:P09917	Human	PMID:11785969
Molecular Function	GO:0005515	protein binding	ALOX5	IPI	UniProtKB:Q9CQI6	Human	PMID:11785969
Molecular Function	GO:0005515	protein binding	ALOX5	IPI	UniProtKB:Q14019	Human	PMID:16924104
Molecular Function	GO:0005515	protein binding	ALOX5	IPI	UniProtKB:Q9UPY3	Human	PMID:19022417
Molecular Function	GO:0005515	protein binding	ALOX5	IPI	UniProtKB:P20292	Human	PMID:19233132
Molecular Function	GO:0005515	protein binding	ALOX5	IPI	UniProtKB:Q16873	Human	PMID:19233132
Molecular Function	GO:0005515	protein binding	ALOX5	IPI	UniProtKB:P07947	Human	PMID:24860872
Molecular Function	GO:0005515	protein binding	ALOX5	IPI	UniProtKB:P08631	Human	PMID:24860872
Molecular Function	GO:0005515	protein binding	ALOX5	IPI	UniProtKB:P09769	Human	PMID:24860872
Molecular Function	GO:0005515	protein binding	ALOX5	IPI	UniProtKB:P17612	Human	PMID:24860872
Molecular Function	GO:0005515	protein binding	ALOX5	IPI	UniProtKB:P50221	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ALOX5	IPI	UniProtKB:Q04864	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ALOX5	IPI	UniProtKB:Q6UWX4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ALOX5	IPI	UniProtKB:Q86Y26	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ALOX5	IPI	UniProtKB:Q8IYX8-2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ALOX5	IPI	UniProtKB:Q8N0S2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ALOX5	IPI	UniProtKB:Q96MT8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ALOX5	IPI	UniProtKB:Q9Y6D9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ALOX5	IPI	UniProtKB:Q6P2R3	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	ALOX5	IPI	UniProtKB:Q6UWX4	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	ALOX5	IPI	UniProtKB:Q8N0S2	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	ALOX5	IPI	UniProtKB:Q96MT8-3	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	ALOX5	IPI	UniProtKB:Q9Y6D9	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	ALOX5	IPI	UniProtKB:P27986	Human	PMID:26210919
Molecular Function	GO:0005515	protein binding	ALOX5	IPI	UniProtKB:Q86Y26	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	ALOX5	IPI	UniProtKB:Q96MT8	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	ALOX5	IPI	UniProtKB:A6NGQ2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALOX5	IPI	UniProtKB:O43716	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALOX5	IPI	UniProtKB:P14061	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALOX5	IPI	UniProtKB:P31025	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALOX5	IPI	UniProtKB:Q6FHY5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALOX5	IPI	UniProtKB:Q6PII3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALOX5	IPI	UniProtKB:Q8IYJ2-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALOX5	IPI	UniProtKB:Q96MT8-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALOX5	IPI	UniProtKB:Q9P0N9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALOX5	IPI	UniProtKB:Q9Y6D9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALOX5	IPI	UniProtKB:Q7Z699	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ALOX5	IPI	UniProtKB:P62993	Human	PMID:7929073
Molecular Function	GO:0005515	protein binding	Alox5	IPI	PR:P30355	Mouse	PMID:19075240
Molecular Function	GO:0005515	protein binding	Alox5	IPI	RGD:2097	Rat	PMID:19075240\|RGD:2313889
Cellular Component	GO:0005737	cytoplasm	Alox5	IDA		Mouse	PMID:12140292
Cellular Component	GO:0005737	cytoplasm	Alox5	IDA		Rat	PMID:15107407\|RGD:1578311
Cellular Component	GO:0005829	cytosol	ALOX5	IDA		Human	PMID:19233132
Cellular Component	GO:0030425	dendrite	Alox5	IDA		Rat	PMID:16606359\|RGD:1626156
Cellular Component	GO:0005615	extracellular space	ALOX5	HDA		Human	PMID:22664934
Cellular Component	GO:0005635	nuclear envelope	ALOX5	IDA		Human	PMID:19233132
Cellular Component	GO:0005635	nuclear envelope	Alox5	IDA		Rat	PMID:16606359\|RGD:1626156
Cellular Component	GO:0005641	nuclear envelope lumen	ALOX5	IDA		Human	PMID:8245774
Cellular Component	GO:0016363	nuclear matrix	ALOX5	IDA		Human	PMID:19233132
Cellular Component	GO:0031965	nuclear membrane	ALOX5	IDA		Human	PMID:8245774
Cellular Component	GO:0005654	nucleoplasm	ALOX5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Alox5	IDA		Mouse	PMID:12140292
Cellular Component	GO:0005634	nucleus	Alox5	IDA		Rat	PMID:16606359\|RGD:1626156
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ALOX5	IDA		Human	PMID:19022417
Cellular Component	GO:0042383	sarcolemma	Alox5	IDA		Rat	PMID:15107407\|RGD:1578311
Biological Process	GO:0002526	acute inflammatory response	Alox5	IMP		Rat	PMID:20204486\|RGD:2317525
Biological Process	GO:0019369	arachidonic acid metabolic process	alox5a	IDA		Zfish	PMID:25025884
Biological Process	GO:0036336	dendritic cell migration	Alox5	IMP		Mouse	MGI:MGI:3713164\|PMID:17392829
Biological Process	GO:0042593	glucose homeostasis	Alox5	IMP		Mouse	MGI:MGI:3803402\|PMID:18421434
Biological Process	GO:0006959	humoral immune response	Alox5	IMP		Mouse	MGI:MGI:4881865\|PMID:21224059
Biological Process	GO:0006954	inflammatory response	Alox5	IMP	MGI:MGI:1857125	Mouse	PMID:11867678
Biological Process	GO:0090594	inflammatory response to wounding	alox5a	IMP	ZFIN:ZDB-GENO-211028-8	Zfish	PMID:32868902
Biological Process	GO:0002232	leukocyte chemotaxis involved in inflammatory response	ALOX5	IMP		Human	PMID:17114001
Biological Process	GO:0002523	leukocyte migration involved in inflammatory response	Alox5	IMP		Mouse	MGI:MGI:6392964\|PMID:28965882
Biological Process	GO:1901753	leukotriene A4 biosynthetic process	ALOX5	IDA		Human	PMID:24282679
Biological Process	GO:1901753	leukotriene A4 biosynthetic process	ALOX5	IMP		Human	PMID:31664810
Biological Process	GO:1901753	leukotriene A4 biosynthetic process	Alox5	IMP		Mouse	MGI:MGI:6392995\|PMID:31642348
Biological Process	GO:0019370	leukotriene biosynthetic process	ALOX5	IDA		Human	PMID:21233389
Biological Process	GO:0019370	leukotriene biosynthetic process	ALOX5	IDA		Human	PMID:24893149
Biological Process	GO:0019370	leukotriene biosynthetic process	Alox5	IMP		Mouse	MGI:MGI:1933116\|PMID:7809134
Biological Process	GO:0019370	leukotriene biosynthetic process	Alox5	IDA		Mouse	PMID:19075240
Biological Process	GO:0006691	leukotriene metabolic process	Alox5	IMP	MGI:MGI:1857125	Mouse	PMID:11867678
Biological Process	GO:0002540	leukotriene production involved in inflammatory response	Alox5	IMP	MGI:MGI:1933120	Mouse	PMID:9091580
Biological Process	GO:2001301	lipoxin biosynthetic process	ALOX5	IMP		Human	PMID:31664810
Biological Process	GO:0016525	negative regulation of angiogenesis	Alox5	IMP		Mouse	MGI:MGI:4948186\|PMID:21307302
Biological Process	GO:0001937	negative regulation of endothelial cell proliferation	Alox5	IMP		Mouse	MGI:MGI:4948186\|PMID:21307302
Biological Process	GO:0050728	negative regulation of inflammatory response	ALOX5	IDA		Human	PMID:21206090
Biological Process	GO:1903573	negative regulation of response to endoplasmic reticulum stress	Alox5	IMP		Mouse	MGI:MGI:5926685\|PMID:28694473
Biological Process	GO:1903671	negative regulation of sprouting angiogenesis	Alox5	IMP		Mouse	MGI:MGI:4948186\|PMID:21307302
Biological Process	GO:0061044	negative regulation of vascular wound healing	Alox5	IMP		Mouse	MGI:MGI:5562469\|PMID:24226420
Biological Process	GO:0061045	negative regulation of wound healing	Alox5	IMP		Mouse	MGI:MGI:5562469\|PMID:24226420
Biological Process	GO:0061045	negative regulation of wound healing	Alox5	IMP		Mouse	MGI:MGI:6392964\|PMID:28965882
Biological Process	GO:0030501	positive regulation of bone mineralization	Alox5	IMP		Mouse	MGI:MGI:6393219\|PMID:24906289
Biological Process	GO:1904960	positive regulation of cytochrome-c oxidase activity	Alox5	IMP		Rat	PMID:15107407\|RGD:1578311
Biological Process	GO:1904999	positive regulation of leukocyte adhesion to arterial endothelial cell	Alox5	IMP		Mouse	MGI:MGI:5619939\|PMID:23720274
Biological Process	GO:0045907	positive regulation of vasoconstriction	Alox5	IMP		Rat	PMID:16331105\|RGD:1626151
Biological Process	GO:1900407	regulation of cellular response to oxidative stress	Alox5	IMP		Mouse	MGI:MGI:5926685\|PMID:28694473
Biological Process	GO:1900015	regulation of cytokine production involved in inflammatory response	Alox5	IMP		Mouse	MGI:MGI:6392964\|PMID:28965882
Biological Process	GO:0045598	regulation of fat cell differentiation	Alox5	IMP		Mouse	MGI:MGI:6393219\|PMID:24906289
Biological Process	GO:0050727	regulation of inflammatory response	ALOX5	IMP		Human	PMID:17114001
Biological Process	GO:0050727	regulation of inflammatory response	Alox5	IMP		Mouse	MGI:MGI:5926685\|PMID:28694473
Biological Process	GO:0050727	regulation of inflammatory response	Alox5	IMP		Mouse	MGI:MGI:69361\|PMID:7969451
Biological Process	GO:0050727	regulation of inflammatory response	Alox5	IMP		Mouse	MGI:MGI:1933116\|PMID:7809134
Biological Process	GO:0106014	regulation of inflammatory response to wounding	Alox5	IMP		Mouse	MGI:MGI:6392964\|PMID:28965882
Biological Process	GO:0050796	regulation of insulin secretion	Alox5	IMP		Mouse	MGI:MGI:3803402\|PMID:18421434
Biological Process	GO:1903426	regulation of reactive oxygen species biosynthetic process	ALOX5	IMP		Human	PMID:26210919
Biological Process	GO:0055093	response to hyperoxia	Alox5	IEP		Rat	PMID:12490039\|RGD:4890420
Biological Process	GO:0007584	response to nutrient	Alox5	IEP		Rat	PMID:16956363\|RGD:1626155
Biological Process	GO:0019233	sensory perception of pain	Alox5	IMP		Rat	PMID:19580807\|RGD:2317533

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.