| GO term: | arachidonate 5-lipoxygenase activity |
| Synonym: | 5-delta-lipoxygenase activity |
| Synonym: | 5Delta-lipoxygenase activity |
| Synonym: | 5-lipoxygenase activity |
| Synonym: | arachidonate:oxygen 5-oxidoreductase activity |
| Synonym: | arachidonic 5-lipoxygenase activity |
| Synonym: | arachidonic acid 5-lipoxygenase activity |
| Synonym: | C-5-lipoxygenase activity |
| Synonym: | delta(5)-lipoxygenase activity |
| Synonym: | delta5-lipoxygenase activity |
| Synonym: | leukotriene A4 synthase |
| Synonym: | leukotriene-A(4) synthase activity |
| Synonym: | leukotriene-A4 synthase activity |
| Synonym: | LTA synthase activity |
| GO id: | GO:0004051 |
| Definition: | Catalysis of the reaction: arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxycosa-6,8,11,14-tetraenoate. |
| Number of paths to term: | 2 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
molecular_functioncatalytic activityoxidoreductase activitydioxygenase activityoxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity1-hydroxy-2-naphthoate 1,2-dioxygenase activity2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity2,2',3-trihydroxybiphenyl dioxygenase activity2,3-dihydroxy DDT 1,2-dioxygenase activity2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity2,3-dihydroxy-p-cumate dioxygenase activity2,3-dihydroxybenzoate 2,3-dioxygenase activity2,3-dihydroxybenzoate 3,4-dioxygenase activity2,3-dihydroxybiphenyl 1,2-dioxygenase activity2,3-dihydroxydiphenyl ether dioxygenase activity2,3-dihydroxyindole 2,3-dioxygenase activity2,4'-dihydroxyacetophenone dioxygenase activity2,5-dihydroxypyridine 5,6-dioxygenase activity2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity2-aminophenol 1,6-dioxygenase activity2-mercaptobenzothiazole dioxygenase activity3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase activity3,4-dihydroxyphenanthrene dioxygenase activity3,4-dihydroxyphenylacetate 2,3-dioxygenase activity3,5-dichlorocatechol 1,2-dioxygenase activity3-carboxyethylcatechol 2,3-dioxygenase activity3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase activity3-hydroxy-2-naphthoate 2,3-dioxygenase activity3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity3-hydroxyanthranilate 3,4-dioxygenase activity4,5-dihydroxybenzo(a)pyrene dioxygenase activity4,5-dihydroxypyrene dioxygenase activity4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity4-hydroxycatechol 1,2-dioxygenase activity4-hydroxymandelate synthase activity4-hydroxyphenylpyruvate dioxygenase activity5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity5-aminosalicylate dioxygenase activity7,8-dihydroxy benzo(a)pyrene dioxygenase activity7,8-dihydroxykynurenate 8,8a-dioxygenase activity9,10-dihydroxybenzo(a)pyrene dioxygenase activityacetylacetone-cleaving enzyme activityacireductone dioxygenase (Ni2+-requiring) activityacireductone dioxygenase [iron(II)-requiring] activityarachidonate 12-lipoxygenase activityarachidonate 15-lipoxygenase activityarachidonate 5-lipoxygenase activity [GO:0004051] (2 genes, 2 annotations)arachidonate 8-lipoxygenase activitybenzo(a)pyrene 11,12-dioxygenase activitybenzo(a)pyrene 4,5-dioxygenase activitybenzo(a)pyrene 7,8-dioxygenase activitybenzo(a)pyrene 9,10-dioxygenase activitybeta-carotene 15,15'-monooxygenase activitybiphenyl-2,3-diol 1,2-dioxygenase activitycaffeate 3,4-dioxygenase activitycarbazole 1,9a-dioxygenase activitycarotenoid dioxygenase activity +catechol dioxygenase activity +chloridazon-catechol dioxygenase activitychlorite O2-lyase activitychlorocatechol 1,2-dioxygenase activitycysteamine dioxygenase activitycysteine dioxygenase activitydihydroxydibenzothiophene dioxygenase activitydihydroxyfluorene dioxygenase activity +diphenyl ether 1,2-dioxygenase activitygallate dioxygenase activitygentisate 1,2-dioxygenase activityhomogentisate 1,2-dioxygenase activityhydroquinone 1,2-dioxygenase activityhydroxyquinol 1,2-dioxygenase activityindole 2,3-dioxygenase activityindoleamine 2,3-dioxygenase activitylignostilbene alpha beta-dioxygenase activitylinoleate 11-lipoxygenase activitylinoleate 8R-lipoxygenase activitylinoleate diol synthase activitylipoxygenase activityp-cumate 2,3-dioxygenase activitypeptide-tryptophan 2,3-dioxygenase activityphenanthrene dioxygenase activityphenanthrene-4-carboxylate dioxygenase activityprotocatechuate 3,4-dioxygenase activityprotocatechuate 3,4-dioxygenase type II activityprotocatechuate 4,5-dioxygenase activitypyrene dioxygenase activitypyridine-3,4-diol dioxygenase activitypyrogallol 1,2-oxygenase activityquercetin 2,3-dioxygenase activitystizolobate synthase activitystizolobinate synthase activitystyrene dioxygenase activitysulfur dioxygenase activitysulfur oxygenase/reductase activitytetrachlorobenzene dioxygenase activitytryptophan 2,3-dioxygenase activitymolecular_functioncatalytic activityoxidoreductase activityoxidoreductase activity, acting on single donors with incorporation of molecular oxygenoxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity1-hydroxy-2-naphthoate 1,2-dioxygenase activity2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity2,2',3-trihydroxybiphenyl dioxygenase activity2,3-dihydroxy DDT 1,2-dioxygenase activity2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity2,3-dihydroxy-p-cumate dioxygenase activity2,3-dihydroxybenzoate 2,3-dioxygenase activity2,3-dihydroxybenzoate 3,4-dioxygenase activity2,3-dihydroxybiphenyl 1,2-dioxygenase activity2,3-dihydroxydiphenyl ether dioxygenase activity2,3-dihydroxyindole 2,3-dioxygenase activity2,4'-dihydroxyacetophenone dioxygenase activity2,5-dihydroxypyridine 5,6-dioxygenase activity2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity2-aminophenol 1,6-dioxygenase activity2-mercaptobenzothiazole dioxygenase activity3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase activity3,4-dihydroxyphenanthrene dioxygenase activity3,4-dihydroxyphenylacetate 2,3-dioxygenase activity3,5-dichlorocatechol 1,2-dioxygenase activity3-carboxyethylcatechol 2,3-dioxygenase activity3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase activity3-hydroxy-2-naphthoate 2,3-dioxygenase activity3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity3-hydroxyanthranilate 3,4-dioxygenase activity4,5-dihydroxybenzo(a)pyrene dioxygenase activity4,5-dihydroxypyrene dioxygenase activity4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity4-hydroxycatechol 1,2-dioxygenase activity4-hydroxymandelate synthase activity4-hydroxyphenylpyruvate dioxygenase activity5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity5-aminosalicylate dioxygenase activity7,8-dihydroxy benzo(a)pyrene dioxygenase activity7,8-dihydroxykynurenate 8,8a-dioxygenase activity9,10-dihydroxybenzo(a)pyrene dioxygenase activityacetylacetone-cleaving enzyme activityacireductone dioxygenase (Ni2+-requiring) activityacireductone dioxygenase [iron(II)-requiring] activityarachidonate 12-lipoxygenase activityarachidonate 15-lipoxygenase activityarachidonate 5-lipoxygenase activity [GO:0004051] (2 genes, 2 annotations)arachidonate 8-lipoxygenase activitybenzo(a)pyrene 11,12-dioxygenase activitybenzo(a)pyrene 4,5-dioxygenase activitybenzo(a)pyrene 7,8-dioxygenase activitybenzo(a)pyrene 9,10-dioxygenase activitybeta-carotene 15,15'-monooxygenase activitybiphenyl-2,3-diol 1,2-dioxygenase activitycaffeate 3,4-dioxygenase activitycarbazole 1,9a-dioxygenase activitycarotenoid dioxygenase activity +catechol dioxygenase activity +chloridazon-catechol dioxygenase activitychlorite O2-lyase activitychlorocatechol 1,2-dioxygenase activitycysteamine dioxygenase activitycysteine dioxygenase activitydihydroxydibenzothiophene dioxygenase activitydihydroxyfluorene dioxygenase activity +diphenyl ether 1,2-dioxygenase activitygallate dioxygenase activitygentisate 1,2-dioxygenase activityhomogentisate 1,2-dioxygenase activityhydroquinone 1,2-dioxygenase activityhydroxyquinol 1,2-dioxygenase activityindole 2,3-dioxygenase activityindoleamine 2,3-dioxygenase activitylignostilbene alpha beta-dioxygenase activitylinoleate 11-lipoxygenase activitylinoleate 8R-lipoxygenase activitylinoleate diol synthase activitylipoxygenase activityp-cumate 2,3-dioxygenase activitypeptide-tryptophan 2,3-dioxygenase activityphenanthrene dioxygenase activityphenanthrene-4-carboxylate dioxygenase activityprotocatechuate 3,4-dioxygenase activityprotocatechuate 3,4-dioxygenase type II activityprotocatechuate 4,5-dioxygenase activitypyrene dioxygenase activitypyridine-3,4-diol dioxygenase activitypyrogallol 1,2-oxygenase activityquercetin 2,3-dioxygenase activitystizolobate synthase activitystizolobinate synthase activitystyrene dioxygenase activitysulfur dioxygenase activitysulfur oxygenase/reductase activitytetrachlorobenzene dioxygenase activitytryptophan 2,3-dioxygenase activityMouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/08/2013 MGI 5.13 |
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