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Alox5 Gene Detail
Summary
  • Symbol
    Alox5
  • Name
    arachidonate 5-lipoxygenase
  • Synonyms
    5LO, 5-LO, 5-LOX, 5LX
  • Feature Type
    protein coding gene
  • IDs
    MGI:87999
    NCBI Gene: 11689
  • Gene Overview
    MyGene.info: ALOX5
Location & Maps
more
  • Sequence Map
    Chr6:116410077-116461178 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      51102 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 53.79 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    ALOX5, arachidonate 5-lipoxygenase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ALOX5, arachidonate 5-lipoxygenase
    Orthology source: HomoloGene
  • Synonyms
    5-LO, 5-LOX, 5LPG, LOG5
  • Links
    NCBI Gene ID: 240
    neXtProt AC: NX_P09917

  • Chr Location
    10q11.2; chr10:45374176-45446121 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human ALOX5 associations

Human Disease Mouse Models
       Asthma, Susceptibility to   OMIM: 600807
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 2 alleles in 4 genetic backgrounds
    104 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Nullizygous mice show altered inflammatory responses. One null mutation causes resistance to lethal anaphylaxis, abnormal eicosanoid production and neutrophil recruitment while another leads to increased body fat, bone density, leptin and VLDL cholesterol levels and resistance to autoimmune uveitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036516 VEGA Gene Model | MGI Sequence Detail 51102 C57BL/6J ±  kb
transcript OTTMUST00000093640 VEGA | MGI Sequence Detail 2821 Not Applicable  
polypeptide OTTMUSP00000051997 VEGA | MGI Sequence Detail 674 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    450 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 35
    Genomic 1
    cDNA 34

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-1286, MGI:2141502
References
more
  • Summaries
    All 157
    Developmental Gene Expression 3
    Gene Ontology 9
    Phenotypes 104
  • Earliest
    J:19332 Funk CD, et al., Targeted gene disruption by homologous recombination. Toward an understanding of specific blood cell functions. Ann N Y Acad Sci. 1994 Apr 18;714:253-8
  • Latest
    J:229695 Lasky CE, et al., Macrophage Polarization during Murine Lyme Borreliosis. Infect Immun. 2015 Jul;83(7):2627-35

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory