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Alox5 Gene Detail
Summary
  • Symbol
    Alox5
  • Name
    arachidonate 5-lipoxygenase
  • Synonyms
    5LO, 5-LO, 5-LOX, 5LX
  • Feature Type
    protein coding gene
  • IDs
    MGI:87999
    NCBI Gene: 11689
  • Gene Overview
    MyGene.info: ALOX5
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr6:116410077-116461178 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      51102 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 53.79 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    ALOX5, arachidonate 5-lipoxygenase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ALOX5, arachidonate 5-lipoxygenase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    5-LO, 5-LOX, 5LPG, LOG5
  • Links
    NCBI Gene ID: 240
    neXtProt AC: NX_P09917
    UniProt: P09917

  • Chr Location
    10q11.21; chr10:45374166-45446121 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human ALOX5 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 2 alleles in 4 genetic backgrounds
    117 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Nullizygous mice show altered inflammatory responses. One null mutation causes resistance to lethal anaphylaxis, abnormal eicosanoid production and neutrophil recruitment while another leads to increased body fat, bone density, leptin and VLDL cholesterol levels and resistance to autoimmune uveitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000036516 VEGA Gene Model | MGI Sequence Detail 51102 C57BL/6J ±  kb
    transcript OTTMUST00000093640 VEGA | MGI Sequence Detail 2821 Not Applicable  
    polypeptide OTTMUSP00000051997 VEGA | MGI Sequence Detail 674 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      450 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      Genomic 1
      cDNA 34

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1286, MGI:2141502
    References
    more
    • Summaries
      All 183
      Developmental Gene Expression 5
      Gene Ontology 9
      Phenotypes 117
    • Earliest
      J:19332 Funk CD, et al., Targeted gene disruption by homologous recombination. Toward an understanding of specific blood cell functions. Ann N Y Acad Sci. 1994 Apr 18;714:253-8
    • Latest
      J:255349 Rauch F, et al., Crispr-Cas9 engineered osteogenesis imperfecta type V leads to severe skeletal deformities and perinatal lethality in mice. Bone. 2018 Feb;107:131-142

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory