Alox5
Gene Detail

Symbol Name ID

Alox5 arachidonate 5-lipoxygenase MGI:87999

Synonyms

5LO, 5-LO, 5-LOX, 5LX

Feature Type

protein coding gene

Genetic Map

Chromosome 6

53.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr6:116410077-116461178 bp, - strand From VEGA annotation of GRCm38   51102 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:561  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: arachidonate 5-lipoxygenase
Gene Tree: Alox5

Human homologs

Human Homolog		ALOX5, arachidonate 5-lipoxygenase
NCBI Gene ID		240
neXtProt AC		NX_P09917
Human Synonyms		5-LO, 5-LOX, 5LPG, LOG5
Human Chr (Location)		10q11.2; chr10:45869624-45941567 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ALOX5

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Nullizygous mice show altered inflammatory responses. One null mutation causes resistance to lethal anaphylaxis, abnormal eicosanoid production and neutrophil recruitment while another leads to increased body fat, bone density, leptin and VLDL cholesterol levels and resistance to autoimmune uveitis.

 

Gene Ontology (GO) classifications

All GO classifications: (33 annotations)

Process	acute inflammatory response, arachidonic acid metabolic process, ...
Component	cytoplasm, cytosol, ...
Function	arachidonate 5-lipoxygenase activity, iron ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (94)    Tissues (94)   
Theiler Stages: 22

Assay Type	Results
RNA in situ	94

cDNA source data(34)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(35) Genomic(1) cDNA(34)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000036516 (Evidence)
Ensembl Gene Model	ENSMUSG00000025701 (Evidence)
Entrez Gene	11689 (Evidence)
UniGene	41072
DFCI	TC1582829, TC1640626, TC1648673, TC1648945
DoTS	DT.110483153, DT.490623, DT.94294351, DT.97338506, DT.99853905
EC	1.13.11.34
Consensus CDS Project	CCDS20452.1
International Mouse Knockout Project Status	Alox5

Sequences

Length	Strain/Species
genomic	OTTMUSG00000036516	VEGA Gene Model | MGI Sequence Detail	51102	C57BL/6J
transcript	OTTMUST00000093640	VEGA | MGI Sequence Detail	2821	Not Applicable
polypeptide	OTTMUSP00000051997	VEGA | MGI Sequence Detail	674	Not Applicable

All sequences(58) RefSeq(2) UniProt(6)

Polymorphisms

RFLP(1) : SNPs(322 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008976	Lipase/lipooxygenase, PLAT/LH2
InterPro	IPR000907	Lipoxygenase
InterPro	IPR020834	Lipoxygenase, conserved site
InterPro	IPR013819	Lipoxygenase, C-terminal
InterPro	IPR020833	Lipoxygenase, iron binding site
InterPro	IPR001024	Lipoxygenase, LH2
InterPro	IPR001885	Lipoxygenase, mammalian
Protein Ontology	PR:000003961	arachidonate 5-lipoxygenase

References

(Earliest) J:19332 Funk CD, et al., Targeted gene disruption by homologous recombination. Toward an understanding of specific blood cell functions. Ann N Y Acad Sci. 1994 Apr 18;714:253-8
(Latest) J:194022 Chou VP, et al., Differential contribution of lipoxygenase isozymes to nigrostriatal vulnerability. Neuroscience. 2013 Jan 3;228:73-82
All references(133)

Other accession IDs

MGD-MRK-1286, MGI:2141502