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Alox5
Gene Detail
 Symbol
Name
ID
Alox5
arachidonate 5-lipoxygenase
MGI:87999
Synonyms 5LO, 5-LO, 5-LOX, 5LX
Feature Type protein coding gene
Genetic Map
Chromosome 6
53.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr6:116410077-116461178 bp, - strand
From VEGA annotation of GRCm38

  51102 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:561  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: arachidonate 5-lipoxygenase
Gene Tree: Alox5

Human
homologs
Human Homolog ALOX5, arachidonate 5-lipoxygenase
NCBI Gene ID 240
neXtProt AC  NX_P09917
Human Synonyms  5-LO, 5-LOX, 5LPG, LOG5
Human Chr (Location)  10q11.2; chr10:45374176-45446119 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ALOX5
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Nullizygous mice show altered inflammatory responses. One null mutation causes resistance to lethal anaphylaxis, abnormal eicosanoid production and neutrophil recruitment while another leads to increased body fat, bone density, leptin and VLDL cholesterol levels and resistance to autoimmune uveitis.
 
Interactions
Alox5 interacts with 118 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process acute inflammatory response, arachidonic acid metabolic process, ...
Component cytoplasm, cytosol, ...
Function arachidonate 5-lipoxygenase activity, dioxygenase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (94)    Tissues (94)   
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(34)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(35) Genomic(1) cDNA(34)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000036516 (Evidence)
Ensembl Gene ModelENSMUSG00000025701 (Evidence)
Entrez Gene11689 (Evidence)
UniGene41072
DFCITC1582829, TC1640626, TC1648673, TC1648945
DoTSDT.110483153, DT.490623, DT.94294351, DT.97338506, DT.99853905
EC1.13.11.34
Consensus CDS ProjectCCDS20452.1
International Mouse Knockout Project StatusAlox5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036516 VEGA Gene Model | MGI Sequence Detail 51102 C57BL/6J ±  kb
transcript OTTMUST00000093640 VEGA | MGI Sequence Detail 2821 Not Applicable 
polypeptide OTTMUSP00000051997 VEGA | MGI Sequence Detail 674 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(2) UniProt(6)
Polymorphisms RFLP(1) : SNPs within 2kb(458 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008976 Lipase/lipooxygenase, PLAT/LH2
InterPro IPR000907 Lipoxygenase
InterPro IPR020834 Lipoxygenase, conserved site
InterPro IPR013819 Lipoxygenase, C-terminal
InterPro IPR020833 Lipoxygenase, iron binding site
InterPro IPR001024 Lipoxygenase, LH2
InterPro IPR001885 Lipoxygenase, mammalian
Protein Ontology PR:000003961 arachidonate 5-lipoxygenase
References (Earliest) J:19332 Funk CD, et al., Targeted gene disruption by homologous recombination. Toward an understanding of specific blood cell functions. Ann N Y Acad Sci. 1994 Apr 18;714:253-8
(Latest) J:212558 da Silva-Souza HA, et al., Inhibitors of the 5-lipoxygenase arachidonic acid pathway induce ATP release and ATP-dependent organic cation transport in macrophages. Biochim Biophys Acta. 2014 Jul;1838(7):1967-77
All references(145)
Other
accession IDs
MGD-MRK-1286, MGI:2141502

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory