Alox5 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Alox5
arachidonate 5-lipoxygenase
MGI:87999

20 phenotypes from 2 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Alox5^tm1Bhk/Alox5^tm1Bhk either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * DBA/2)	abnormal inflammatory response	J:68714
	abnormal neutrophil physiology	J:68714
	abnormal thromboxane level	J:68714
	decreased acute inflammation	J:68714
	decreased leukotriene level	J:68714
	decreased susceptibility to type I hypersensitivity reaction	J:68714
	normal hematopoietic system phenotype	J:68714
	impaired neutrophil chemotaxis	J:68714
	impaired neutrophil recruitment	J:68714
	increased prostaglandin level	J:68714
Alox5^tm1Fun/Alox5^tm1Fun B6.129S2-Alox5^tm1Fun	normal immune system phenotype	J:89268
Alox5^tm1Fun/Alox5^tm1Fun B6.129S2-Alox5^tm1Fun/J	decreased susceptibility to experimental autoimmune uveoretinitis	J:108446
	increased bone mineral density	J:104825
	increased circulating leptin level	J:104825
	increased circulating VLDL cholesterol level	J:104825
	increased total fat pad weight	J:104825
Alox5^tm1Fun/Alox5^tm1Fun involves: 129S2/SvPas * C57BL/6	abnormal immune system physiology	J:21372
	normal cardiovascular system phenotype	J:21372
	decreased inflammatory response	J:21372, J:75371
	normal hematopoietic system phenotype	J:21372
	normal immune system phenotype	J:21372
	small spleen	J:21372

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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