Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ADAMTS13
  • Mouse genes Adamts13
  • Rat genes Adamts13
  • Zfish genes adamts13
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Adamts13

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004175	endopeptidase activity	Adamts13	IMP	MGI:MGI:3605825	Mouse	PMID:16200209
Molecular Function	GO:0004175	endopeptidase activity	Adamts13	IDA		Rat	PMID:19652891|RGD:2315953
Molecular Function	GO:0008233	peptidase activity	Adamts13	IDA		Rat	PMID:16689760|RGD:1598737
Molecular Function	GO:0008233	peptidase activity	adamts13	IDA		Zfish	PMID:31753928
Molecular Function	GO:0005515	protein binding	ADAMTS13	IPI	UniProtKB:P04275	Human	PMID:12775718
Molecular Function	GO:0005515	protein binding	ADAMTS13	IPI	UniProtKB:P04275	Human	PMID:16221672
Molecular Function	GO:0005515	protein binding	ADAMTS13	IPI	UniProtKB:P04275	Human	PMID:18492805
Molecular Function	GO:0005515	protein binding	ADAMTS13	IPI	UniProtKB:P04275	Human	PMID:25512528
Cellular Component	GO:0005615	extracellular space	Adamts13	IDA		Rat	PMID:19652891|RGD:2315953
Biological Process	GO:0071353	cellular response to interleukin-4	Adamts13	IEP		Rat	PMID:18433458|RGD:2315954
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Adamts13	IEP		Rat	PMID:22871409|RGD:7207038
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Adamts13	IEP		Rat	PMID:18433458|RGD:2315954
Biological Process	GO:0071346	cellular response to type II interferon	Adamts13	IEP		Rat	PMID:18433458|RGD:2315954
Biological Process	GO:0043171	peptide catabolic process	ADAMTS13	IDA		Human	PMID:11535495
Biological Process	GO:0030163	protein catabolic process	Adamts13	IDA		Rat	PMID:19652891|RGD:2315953
Biological Process	GO:0006508	proteolysis	ADAMTS13	IDA		Human	PMID:11535495
Biological Process	GO:0006508	proteolysis	adamts13	IDA		Zfish	PMID:31753928
Biological Process	GO:0014075	response to amine	Adamts13	IEP		Rat	PMID:17383642|RGD:10449031
Biological Process	GO:0070670	response to interleukin-4	Adamts13	IEP		Rat	PMID:18433458|RGD:2315954
Biological Process	GO:0035864	response to potassium ion	Adamts13	IEP		Rat	PMID:17804457|RGD:8554499
Biological Process	GO:0009636	response to toxic substance	Adamts13	IEP		Rat	PMID:16689760|RGD:1598737
Biological Process	GO:0034612	response to tumor necrosis factor	Adamts13	IEP		Rat	PMID:18433458|RGD:2315954
Biological Process	GO:0034341	response to type II interferon	Adamts13	IEP		Rat	PMID:18433458|RGD:2315954

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern