Adamts13
Gene Detail

Symbol Name ID

Adamts13 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13 MGI:2685556

Synonyms

LOC279028, vWF-CP mRNA for von Willebrand factor-cleaving

Feature Type

protein coding gene

Genetic Map

Chromosome 2

19.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr2:26973416-27009628 bp, + strand From VEGA annotation of GRCm38   36213 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:16372  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Adamts13

Human homologs

Human Homolog		ADAMTS13, ADAM metallopeptidase with thrombospondin type 1 motif, 13
NCBI Gene ID		11093
neXtProt AC		NX_Q76LX8
Human Synonyms		13, ADAM-TS, ADAM-TS13, ADAMTS-13, C9orf8, TTP, vWF-CP, VWFCP
Human Chr (Location)		9q34; chr9:136279459-136324508 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ADAMTS13

Alleles and phenotypes

All alleles(10) : Targeted(7) Gene trapped(2) Spontaneous(1)
 

Homozygous mutation of this gene results in thrombocytopenia, decreased survival, and increased susceptibility to developing thrombotic thrombocytopenic purpura after shiga toxin injection. On a different background, mutants are viable and fertile.

 
Human Diseases Modeled Using Mouse Adamts13 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	blood coagulation, hemostasis, ...
Component	extracellular region, extracellular space, ...
Function	endopeptidase activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (1)    Tissues (1)   
Theiler Stages: 11

Assay Type	Results
RT-PCR	1

cDNA source data(2)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(5) cDNA(2) Primer pair(1) Other(2)
Microarray probesets(1)

Other database links

VEGA Gene Model	OTTMUSG00000011842 (Evidence)
Ensembl Gene Model	ENSMUSG00000014852 (Evidence)
Entrez Gene	279028 (Evidence)
UniGene	330084
DFCI	TC1595101
DoTS	DT.101346340, DT.103581928, DT.94386939
EC	3.4.24.87
Consensus CDS Project	CCDS15820.1
International Mouse Knockout Project Status	Adamts13

Sequences

Length	Strain/Species
genomic	OTTMUSG00000011842	VEGA Gene Model | MGI Sequence Detail	36213	C57BL/6J
transcript	OTTMUST00000027822	VEGA | MGI Sequence Detail	4506	Not Applicable
polypeptide	OTTMUSP00000012637	VEGA | MGI Sequence Detail	1426	Not Applicable

All sequences(28) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(148 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000859	CUB
InterPro	IPR024079	Metallopeptidase, catalytic domain
InterPro	IPR001590	Peptidase M12B, ADAM/reprolysin
InterPro	IPR013273	Peptidase M12B, ADAM-TS
InterPro	IPR000884	Thrombospondin, type 1 repeat
Protein Ontology	PR:000003728	A disintegrin and metalloproteinase with thrombospondin motifs 13

References

(Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:192140 De Meyer SF, et al., Protective anti-inflammatory effect of ADAMTS13 on myocardial ischemia/reperfusion injury in mice. Blood. 2012 Dec 20;120(26):5217-23
All references(49)