About   Help   FAQ
Adamts13
Gene Detail
Symbol

Name
ID
Adamts13
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13
MGI:2685556
Synonyms
LOC279028, vWF-CP mRNA for von Willebrand factor-cleaving
Feature Type
protein coding gene
Genetic Map
Chromosome 2
19.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:26973416-27009628 bp, + strand
From VEGA annotation of GRCm38

  36213 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:16372  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ADAMTS13
Gene Tree: Adamts13

Human
homologs
ADAMTS13, ADAM metallopeptidase with thrombospondin type 1 motif, 13
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 11093
neXtProt AC: NX_Q76LX8

Human Synonyms: ADAM-TS13, ADAMTS-13, C9orf8, vWF-CP, VWFCP

Human Chr (Location): 9q34; chr9:133414339-133459403 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ADAMTS13

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(2) Spontaneous(1) Targeted(8)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation of this gene results in thrombocytopenia, decreased survival, and increased susceptibility to developing thrombotic thrombocytopenic purpura after shiga toxin injection. On a different background, mutants are viable and fertile.
 
Human Diseases Modeled in Mice Using Adamts13 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Adamts13 interacts with 31 markers (Mir24-1, Mir24-2, Mir137, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process blood coagulation, hemostasis, ...
Component extracellular region, extracellular space, ...
Function endopeptidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (1)    Tissues (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 1
cDNA source data(2)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA ADAMTS13    NEW 
Molecular
reagents
All nucleic(5) cDNA(2) Primer pair(1) Other(2)
Microarray probesets(1)
Other database
links
VEGA Gene Model OTTMUSG00000011842 (Evidence)
Ensembl Gene Model ENSMUSG00000014852 (Evidence)
Entrez Gene 279028 (Evidence)
UniGene 330084
DFCI TC1595101
DoTS DT.101346340, DT.94386939, DT.103581928
EC 3.4.24.87
Consensus CDS Project CCDS15820.1, CCDS71010.1
International Mouse Phenotyping Consortium Status Adamts13
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011842 VEGA Gene Model | MGI Sequence Detail 36213 C57BL/6J ±  kb
transcript OTTMUST00000027822 VEGA | MGI Sequence Detail 4506 Not Applicable 
polypeptide OTTMUSP00000012637 VEGA | MGI Sequence Detail 1426 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(19) UniProt(3)
Polymorphisms
SNPs within 2kb(329 from dbSNP Build 137)    SNPs within 2kb including multiple locations(331)
Protein-related
information
ResourceIDDescription
InterPro IPR000859 CUB domain
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR001590 Peptidase M12B, ADAM/reprolysin
InterPro IPR013273 Peptidase M12B, ADAM-TS
InterPro IPR000884 Thrombospondin, type 1 repeat
Protein Ontology PR:000003728 a disintegrin and metalloproteinase with thrombospondin motifs 13
References
(Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:219914 Concepcion D, et al., Nxf1 Natural Variant E610G Is a Semi-dominant Suppressor of IAP-Induced RNA Processing Defects. PLoS Genet. 2015 Apr;11(4):e1005123
All references(54)
Disease annotation references (2)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/30/2015
MGI 5.22
The Jackson Laboratory