Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ADAM19
  • Mouse genes Adam19
  • Rat genes Adam19
  • Zfish genes adam19a,adam19b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Adam19

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004222	metalloendopeptidase activity	ADAM19	IMP		Human	PMID:11162584
Molecular Function	GO:0004222	metalloendopeptidase activity	ADAM19	IMP		Human	PMID:17112471
Molecular Function	GO:1902945	metalloendopeptidase activity involved in amyloid precursor protein catabolic process	ADAM19	IMP		Human	PMID:17112471
Molecular Function	GO:0005515	protein binding	ADAM19	IPI	UniProtKB:Q7SIH1	Human	PMID:11162584
Molecular Function	GO:0005515	protein binding	ADAM19	IPI	UniProtKB:P05067	Human	PMID:17112471
Molecular Function	GO:0005515	protein binding	ADAM19	IPI	UniProtKB:O95153	Human	PMID:25825872
Molecular Function	GO:0005515	protein binding	ADAM19	IPI	UniProtKB:Q8TE68	Human	PMID:25825872
Molecular Function	GO:0005515	protein binding	Adam19	IPI	UniProtKB:O89032	Mouse	MGI:MGI:6158822|PMID:12615925
Molecular Function	GO:0005515	protein binding	Adam19	IPI	UniProtKB:Q99962	Mouse	MGI:MGI:3687666|PMID:10531379
Molecular Function	GO:0005515	protein binding	Adam19	IPI	UniProtKB:Q9UI95	Mouse	MGI:MGI:3828416|PMID:10527948
Molecular Function	GO:0017124	SH3 domain binding	Adam19	IMP		Mouse	MGI:MGI:6158822|PMID:12615925
Cellular Component	GO:0062023	collagen-containing extracellular matrix	ADAM19	HDA		Human	PMID:28344315
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Adam19	HDA		Mouse	MGI:MGI:6201834|PMID:22159717
Cellular Component	GO:0005794	Golgi apparatus	Adam19	IDA		Mouse	PMID:11116142
Cellular Component	GO:0005634	nucleus	ADAM19	IDA		Human	PMID:19727588
Biological Process	GO:0042987	amyloid precursor protein catabolic process	ADAM19	IMP		Human	PMID:17112471
Biological Process	GO:0007507	heart development	Adam19	IMP	MGI:MGI:3028702	Mouse	PMID:14673146
Biological Process	GO:0007507	heart development	Adam19	IMP	MGI:MGI:3620562	Mouse	PMID:14975714
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	Adam19	IDA		Mouse	PMID:11116142
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	Adam19	IMP		Mouse	PMID:11116142
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	Adam19	IMP	MGI:MGI:3620562	Mouse	PMID:14975714
Biological Process	GO:0001890	placenta development	ADAM19	IEP		Human	PMID:19727588
Biological Process	GO:2000049	positive regulation of cell-cell adhesion mediated by cadherin	ADAM19	IDA		Human	PMID:19727588
Biological Process	GO:0010628	positive regulation of gene expression	ADAM19	IDA		Human	PMID:19727588
Biological Process	GO:0016485	protein processing	ADAM19	IMP		Human	PMID:17112471

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern