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Adam19 Gene Detail
Summary
  • Symbol
    Adam19
  • Name
    a disintegrin and metallopeptidase domain 19 (meltrin beta)
  • Synonyms
    Mltnb
  • Feature Type
    protein coding gene
  • IDs
    MGI:105377
    NCBI Gene: 11492
  • Gene Overview
    MyGene.info: ADAM19
Location & Maps
more
  • Sequence Map
    Chr11:46055992-46147343 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      91352 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ADAM19, ADAM metallopeptidase domain 19
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ADAM19, ADAM metallopeptidase domain 19
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FKSG34, MADDAM, MLTNB
  • Links
    NCBI Gene ID: 8728
    neXtProt AC: NX_Q9H013

  • Chr Location
    5q33.3; chr5:157477304-157575823 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    157
  • Chemically induced (other)
    1
  • Gene trapped
    151
  • Targeted
    5
  • Genomic Mutations
    1 involving Adam19
  • Incidental Mutations
Homozygous null mice exhibit cardiac developmental defects and die perinatally.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005488 VEGA Gene Model | MGI Sequence Detail 91352 C57BL/6J ±  kb
transcript OTTMUST00000012216 VEGA | MGI Sequence Detail 6383 Not Applicable  
polypeptide OTTMUSP00000005634 VEGA | MGI Sequence Detail 920 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    601 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 84
    cDNA 82
    Primer pair 1
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-33046, MGI:2144353
References
more
  • Summaries
    All 55
    Developmental Gene Expression 13
    Gene Ontology 7
    Phenotypes 19
  • Earliest
    J:30529 Yagami-Hiromasa T, et al., A metalloprotease-disintegrin participating in myoblast fusion [see comments]. Nature. 1995 Oct 19;377(6550):652-6
  • Latest
    J:213829 Bard-Chapeau EA, et al., Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects. PLoS One. 2014;9(2):e89397

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory