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Adam19
Gene Detail
Symbol

Name
ID
Adam19
a disintegrin and metallopeptidase domain 19 (meltrin beta)
MGI:105377
Synonyms
Mltnb
Feature Type
protein coding gene
Genetic Map
Chromosome 11
27.54 cM, cytoband A5-B1.1
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr11:46055992-46147343 bp, + strand
From VEGA annotation of GRCm38

  91352 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74925  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Adam19

Human
homologs
Human Homolog ADAM19, ADAM metallopeptidase domain 19
NCBI Gene ID 8728
neXtProt AC  NX_Q9H013
Human Synonyms  MADDAM, MLTNB
Human Chr (Location)  5q33.3; chr5:157477304-157575823 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(156) : Gene trapped(151) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit cardiac developmental defects and die perinatally.
 
Interactions
Adam19 interacts with 389 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process heart development, membrane protein ectodomain proteolysis, ...
Component integral component of membrane, membrane
Function hydrolase activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (130)    Tissues (88)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 17
RNA in situ 96
Western blot 7
RT-PCR 10
cDNA source data(81)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(84) cDNA(82) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000005488 (Evidence)
Ensembl Gene ModelENSMUSG00000011256 (Evidence)
Entrez Gene11492 (Evidence)
UniGene89940
DFCITC1577379, TC1698210, TC1658784, TC1709332
DoTSDT.489807, DT.103587201, DT.101377299
NIA Mouse Gene IndexU012500
EC3.4.24.-
Consensus CDS ProjectCCDS24571.1
International Mouse Knockout Project StatusAdam19
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005488 VEGA Gene Model | MGI Sequence Detail 91352 C57BL/6J ±  kb
transcript OTTMUST00000012216 VEGA | MGI Sequence Detail 6383 Not Applicable 
polypeptide OTTMUSP00000005634 VEGA | MGI Sequence Detail 920 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(8) UniProt(9)
Polymorphisms
RFLP(2) : SNPs within 2kb(602 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006586 ADAM, cysteine-rich
InterPro IPR001762 Blood coagulation inhibitor, Disintegrin
InterPro IPR018358 Disintegrin, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR001590 Peptidase M12B, ADAM/reprolysin
InterPro IPR002870 Peptidase M12B, propeptide
Protein Ontology PR:000003714 disintegrin and metalloproteinase domain-containing protein 19
References
(Earliest) J:30529 Yagami-Hiromasa T, et al., A metalloprotease-disintegrin participating in myoblast fusion [see comments]. Nature. 1995 Oct 19;377(6550):652-6
(Latest) J:213829 Bard-Chapeau EA, et al., Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects. PLoS One. 2014;9(2):e89397
All references(60)
Other
accession IDs
MGD-MRK-33046, MGI:2144353

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory