Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Actn4

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes ACTN4
- Mouse genes Actn4
- Rat genes Actn4
- Zfish genes actn4
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Actn4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051015	actin filament binding	ACTN4	IDA		Human	PMID:12411747
Molecular Function	GO:0051015	actin filament binding	ACTN4	IMP		Human	PMID:25918384
Molecular Function	GO:0051015	actin filament binding	Actn4	IDA		Mouse	MGI:MGI:3794927\|PMID:18332111
Molecular Function	GO:0051015	actin filament binding	Actn4	IDA		Mouse	PMID:15465019
Molecular Function	GO:0031490	chromatin DNA binding	ACTN4	IDA		Human	PMID:25411248
Molecular Function	GO:0016922	nuclear receptor binding	ACTN4	IPI	UniProtKB:P37231	Human	PMID:22351778
Molecular Function	GO:0030374	nuclear receptor coactivator activity	ACTN4	IMP		Human	PMID:22351778
Molecular Function	GO:0042974	nuclear retinoic acid receptor binding	ACTN4	IPI	UniProtKB:P10276	Human	PMID:22351778
Molecular Function	GO:0001882	nucleoside binding	ACTN4	IDA		Human	PMID:12411747
Molecular Function	GO:0005515	protein binding	ACTN4	IPI	UniProtKB:O00151	Human	PMID:10753915
Molecular Function	GO:0005515	protein binding	ACTN4	IPI	UniProtKB:Q8IVG9	Human	PMID:15619032
Molecular Function	GO:0005515	protein binding	ACTN4	IPI	UniProtKB:Q8N3V7-1	Human	PMID:15841212
Molecular Function	GO:0005515	protein binding	ACTN4	IPI	UniProtKB:Q8N3V7-3	Human	PMID:15841212
Molecular Function	GO:0005515	protein binding	ACTN4	IPI	UniProtKB:P18206	Human	PMID:15988023
Molecular Function	GO:0005515	protein binding	ACTN4	IPI	UniProtKB:O00151	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	ACTN4	IPI	UniProtKB:Q9NPC6	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	ACTN4	IPI	UniProtKB:P35222	Human	PMID:16204054
Molecular Function	GO:0005515	protein binding	ACTN4	IPI	UniProtKB:Q07157	Human	PMID:16944923
Molecular Function	GO:0005515	protein binding	ACTN4	IPI	UniProtKB:Q9NPC6	Human	PMID:19447967
Molecular Function	GO:0005515	protein binding	ACTN4	IPI	UniProtKB:P37231	Human	PMID:22351778
Molecular Function	GO:0005515	protein binding	ACTN4	IPI	UniProtKB:P46940	Human	PMID:22662192
Molecular Function	GO:0005515	protein binding	ACTN4	IPI	UniProtKB:P03466	Human	PMID:24802111
Molecular Function	GO:0005515	protein binding	ACTN4	IPI	UniProtKB:Q5L4H4	Human	PMID:24802111
Molecular Function	GO:0005515	protein binding	ACTN4	IPI	UniProtKB:P35222	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	ACTN4	IPI	UniProtKB:P19838	Human	PMID:25411248
Molecular Function	GO:0005515	protein binding	ACTN4	IPI	UniProtKB:Q04206	Human	PMID:25411248
Molecular Function	GO:0005515	protein binding	ACTN4	IPI	UniProtKB:A8K571	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ACTN4	IPI	UniProtKB:B2R8Y4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ACTN4	IPI	UniProtKB:Q9NPC6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ACTN4	IPI	UniProtKB:O60294	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	ACTN4	IPI	UniProtKB:O94875-10	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	ACTN4	IPI	UniProtKB:P50222	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	ACTN4	IPI	UniProtKB:Q9NPC6	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	ACTN4	IPI	UniProtKB:P46940	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	ACTN4	IPI	UniProtKB:Q9NPC6	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	ACTN4	IPI	UniProtKB:O00151	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	ACTN4	IPI	UniProtKB:O00151	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	ACTN4	IPI	UniProtKB:Q08043	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN4	IPI	UniProtKB:Q8IY33	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN4	IPI	UniProtKB:Q8TBB1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN4	IPI	UniProtKB:Q9NPC6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN4	IPI	UniProtKB:Q9NWQ9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Actn4	IPI	UniProtKB:P39447	Mouse	MGI:MGI:3696587\|PMID:16944923
Molecular Function	GO:0005515	protein binding	Actn4	IPI	UniProtKB:Q6ZU15	Mouse	MGI:MGI:6716979\|PMID:33228246
Molecular Function	GO:0005515	protein binding	Actn4	IPI	UniProtKB:Q3TN34	Mouse	MGI:MGI:3794927\|PMID:18332111
Molecular Function	GO:0005515	protein binding	Actn4	IPI	UniProtKB:Q3TN34	Mouse	MGI:MGI:5514064\|PMID:23890175
Molecular Function	GO:0005515	protein binding	Actn4	IPI	UniProtKB:Q04207	Mouse	MGI:MGI:5640903\|PMID:25411248
Molecular Function	GO:0005515	protein binding	Actn4	IPI	PR:Q8K4E0	Mouse	PMID:22693585
Molecular Function	GO:0005515	protein binding	Actn4	IPI	PR:E9Q9D5	Mouse	PMID:23055941
Molecular Function	GO:0005515	protein binding	Actn4	IPI	PR:P29477	Mouse	PMID:12960352
Molecular Function	GO:0005515	protein binding	Actn4	IPI	RGD:1302984	Rat	PMID:15140894\|RGD:1303994
Molecular Function	GO:0005515	protein binding	Actn4	IPI	RGD:1359203	Rat	PMID:15505042\|RGD:1359754
Molecular Function	GO:0005515	protein binding	Actn4	IPI	UniProtKB:P19357	Rat	PMID:16396496\|RGD:8553682
Molecular Function	GO:0005515	protein binding	Actn4	IPI	RGD:71058	Rat	PMID:16518874\|RGD:10054427
Molecular Function	GO:0042803	protein homodimerization activity	ACTN4	IPI	UniProtKB:O43707	Human	PMID:22351778
Molecular Function	GO:0044877	protein-containing complex binding	Actn4	IPI	RGD:620460	Rat	PMID:15331416\|RGD:1600864
Molecular Function	GO:0003723	RNA binding	ACTN4	HDA		Human	PMID:22658674
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ACTN4	IDA		Human	PMID:25411248
Molecular Function	GO:0005200	structural constituent of cytoskeleton	Actn4	IMP		Mouse	MGI:MGI:3692220\|PMID:16837921
Molecular Function	GO:0005200	structural constituent of cytoskeleton	Actn4	IMP		Mouse	MGI:MGI:2664075\|PMID:12782671
Molecular Function	GO:0003713	transcription coactivator activity	ACTN4	IMP		Human	PMID:25411248
Molecular Function	GO:0044325	transmembrane transporter binding	ACTN4	IPI	UniProtKB:Q14524	Human	PMID:19943616
Molecular Function	GO:0031625	ubiquitin protein ligase binding	Actn4	IPI	RGD:70074	Rat	PMID:10673389\|RGD:61532
Cellular Component	GO:0015629	actin cytoskeleton	ACTN4	IDA		Human	PMID:25918384
Cellular Component	GO:0015629	actin cytoskeleton	ACTN4	IDA		Human	PMID:15048094
Cellular Component	GO:0005911	cell-cell junction	Actn4	IDA		Mouse	MGI:MGI:3794927\|PMID:18332111
Cellular Component	GO:0030864	cortical actin cytoskeleton	Actn4	IDA		Mouse	MGI:MGI:3692220\|PMID:16837921
Cellular Component	GO:0030863	cortical cytoskeleton	Actn4	IDA		Mouse	PMID:12960352
Cellular Component	GO:0005737	cytoplasm	ACTN4	HDA		Human	PMID:16791210
Cellular Component	GO:0005737	cytoplasm	ACTN4	IDA		Human	PMID:22351778
Cellular Component	GO:0005737	cytoplasm	ACTN4	IDA		Human	PMID:25411248
Cellular Component	GO:0005737	cytoplasm	ACTN4	IDA		Human	PMID:9508771
Cellular Component	GO:0005737	cytoplasm	Actn4	IDA		Mouse	PMID:12960352
Cellular Component	GO:0005737	cytoplasm	Actn4	IDA		Rat	PMID:10673389\|RGD:61532
Cellular Component	GO:0070062	extracellular exosome	ACTN4	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	ACTN4	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	ACTN4	HDA		Human	PMID:21362503
Cellular Component	GO:0070062	extracellular exosome	ACTN4	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	ACTN4	HDA		Human	PMID:16502470
Cellular Component	GO:0005925	focal adhesion	ACTN4	HDA		Human	PMID:21423176
Cellular Component	GO:0005925	focal adhesion	Actn4	IDA		Mouse	MGI:MGI:3692220\|PMID:16837921
Cellular Component	GO:0043005	neuron projection	Actn4	IDA		Rat	PMID:20008558\|RGD:8553724
Cellular Component	GO:0005634	nucleus	ACTN4	IDA		Human	PMID:22351778
Cellular Component	GO:0005634	nucleus	ACTN4	IDA		Human	PMID:25411248
Cellular Component	GO:0005634	nucleus	ACTN4	IDA		Human	PMID:9508771
Cellular Component	GO:0005634	nucleus	Actn4	IDA		Rat	PMID:15942958\|RGD:1598733
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ACTN4	IDA		Human	PMID:15619032
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Actn4	IDA		Mouse	MGI:MGI:6716979\|PMID:33228246
Cellular Component	GO:0032991	protein-containing complex	ACTN4	IDA		Human	PMID:11948184
Cellular Component	GO:0032991	protein-containing complex	Actn4	IDA		Rat	PMID:15331416\|RGD:1600864
Cellular Component	GO:0032991	protein-containing complex	Actn4	IDA		Rat	PMID:15823548\|RGD:1600561
Cellular Component	GO:0031143	pseudopodium	Actn4	IDA		Mouse	MGI:MGI:3688351\|PMID:15633123
Cellular Component	GO:1990904	ribonucleoprotein complex	ACTN4	IDA		Human	PMID:17289661
Cellular Component	GO:0001725	stress fiber	Actn4	IDA		Mouse	MGI:MGI:5514064\|PMID:23890175
Cellular Component	GO:0001725	stress fiber	Actn4	IDA		Mouse	MGI:MGI:3577135\|PMID:15841212
Cellular Component	GO:0001725	stress fiber	Actn4	IDA		Rat	PMID:15505042\|RGD:1359754
Cellular Component	GO:0030018	Z disc	Actn4	IDA		Mouse	PMID:20215401
Cellular Component	GO:0030018	Z disc	Actn4	IDA		Mouse	PMID:20368620
Biological Process	GO:0051017	actin filament bundle assembly	Actn4	IDA		Mouse	MGI:MGI:3577135\|PMID:15841212
Biological Process	GO:0070830	bicellular tight junction assembly	Actn4	IMP		Mouse	MGI:MGI:3794927\|PMID:18332111
Biological Process	GO:0032835	glomerulus development	Actn4	IDA		Mouse	MGI:MGI:2664075\|PMID:12782671
Biological Process	GO:1900025	negative regulation of substrate adhesion-dependent cell spreading	ACTN4	IMP		Human	PMID:25918384
Biological Process	GO:0035357	peroxisome proliferator activated receptor signaling pathway	ACTN4	IDA		Human	PMID:22351778
Biological Process	GO:0090521	podocyte cell migration	Actn4	IMP		Mouse	MGI:MGI:3692220\|PMID:16837921
Biological Process	GO:0030335	positive regulation of cell migration	ACTN4	IMP		Human	PMID:25918384
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	ACTN4	IMP		Human	PMID:25411248
Biological Process	GO:0048549	positive regulation of pinocytosis	Actn4	IMP		Mouse	MGI:MGI:3687817\|PMID:10954430
Biological Process	GO:1902396	protein localization to bicellular tight junction	Actn4	IMP		Mouse	MGI:MGI:3794927\|PMID:18332111
Biological Process	GO:0042981	regulation of apoptotic process	Actn4	IMP		Rat	PMID:16014575\|RGD:1598732
Biological Process	GO:1903506	regulation of nucleic acid-templated transcription	ACTN4	IMP		Human	PMID:22351778
Biological Process	GO:0001666	response to hypoxia	Actn4	IEP		Rat	PMID:15942958\|RGD:1598733
Biological Process	GO:0048384	retinoic acid receptor signaling pathway	ACTN4	IDA		Human	PMID:22351778
Biological Process	GO:0033209	tumor necrosis factor-mediated signaling pathway	ACTN4	IDA		Human	PMID:25411248
Biological Process	GO:0030050	vesicle transport along actin filament	ACTN4	IMP		Human	PMID:25918384

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/14/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.