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Gene Expression Data
Assay Details
Assay
Reference: J:233142 Hilton MJ, et al., Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. Nat Med. 2008 Mar;14(3):306-14
Assay type: RNA in situ
MGI Accession ID: MGI:7593622
Gene symbol: Mmp13
Gene name: matrix metallopeptidase 13
Probe: Mmp13 probe
Probe preparation: Antisense RNA
Results
Specimen 3b WT: embryonic day 18.5; Notch1tm2Rko/Notch1tm2Rko, Notch2tm3Grid/Notch2tm3Grid (more )
Structure Level Pattern Image Note
TS26: epiphyseal plate Strong Regionally restricted 3b Mmp13 WT Expressed at high levels in a single row of terminal hypertrophic chondrocytes at the chondro-osseous junction.
Specimen 3b PNN: embryonic day 18.5; Notch1tm2Rko/Notch1tm1Con, Notch2tm3Grid/Notch2tm3Grid, Tg(Prrx1-cre)1Cjt/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: epiphyseal plate Strong Regionally restricted 3b Mmp13 PNN Expressed at a lower level in many rows of hypertrophic cells before eventually reaching the higher level in the mutant.
Specimen 3c WT: embryonic day 14.5; Notch1tm2Rko/Notch1tm2Rko, Notch2tm3Grid/Notch2tm3Grid (more )
Structure Level Pattern Image Note
TS22: tibia cartilage condensation Present Regionally restricted 3c Mmp13 WT Expressed in a band of terminal hypotrophic chondrocytes.
Specimen 3c PNN: embryonic day 14.5; Notch1tm2Rko/Notch1tm1Con, Notch2tm3Grid/Notch2tm3Grid, Tg(Prrx1-cre)1Cjt/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: tibia cartilage condensation Present Regionally restricted 3c Mmp13 PNN Markedly reduced number of positive terminal hypotrophic chondrocytes, compared with the control.
Specimen S3c Control E18.5: embryonic day 18.5; Psen2tm1Bdes/Psen2tm1Bdes (more )
Structure Level Pattern Image Note
TS26: epiphyseal plate Present Regionally restricted S3c E18.5 control Expressed at high levels in a single row of terminal hypertrophic chondrocytes at the chondro-osseous junction.
Specimen S3c PPS E18.5: embryonic day 18.5; Psen1tm2Shn/Psen1tm2Shn, Psen2tm1Bdes/Psen2tm1Bdes, Tg(Prrx1-cre)1Cjt/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: epiphyseal plate Present Regionally restricted S3c E18.5 PPS Expressed at a lower level in many rows of hypertrophic cells before eventually reaching the higher level in the mutant.
Specimen S3c Control E14.5: embryonic day 14.5; Psen2tm1Bdes/Psen2tm1Bdes (more )
Structure Level Pattern Image Note
TS22: tibia cartilage condensation Present Regionally restricted S3c E14.5 control Expressed in a band of terminal hypotrophic chondrocytes.
Specimen S3c PPS E14.5: embryonic day 14.5; Psen1tm2Shn/Psen1tm2Shn, Psen2tm1Bdes/Psen2tm1Bdes, Tg(Prrx1-cre)1Cjt/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: tibia cartilage condensation Present Regionally restricted S3c E14.5 PPS Markedly reduced number of positive terminal hypotrophic chondrocytes, compared with the control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory