Psen1^tm2Shn
Targeted Allele Detail

Summary

• Symbol: Psen1^tm2Shn
• Name: presenilin 1; targeted mutation 2, Jie Shen
• MGI ID: MGI:2449304
• Synonyms: fPS1, fPsen1, Presenilin 1 floxed, PS1^C, Psen1^f
• Gene: Psen1 Location: Chr12:83734926-83781869 bp, + strand Genetic Position: Chr12, 38.84 cM
• Alliance: Psen1^tm2Shn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71606
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A single loxP site was inserted into intron 1 and a loxP-flanked hygromycin and thymidine kinase selection cassette was inserted into intron 3. The drug selection cassette was removed in ES cells by transient Cre expression in ES cells prior to the production of mice. The final allele has single loxP sites flanking exons 2 and 3. (J:60306)

Disease models

Expression

In Mice Carrying this Mutation:

52110 assay results 4 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Psen1 Mutation: 46 strains or lines available

References

• Original: J:71606 Yu H, et al., App processing and synaptic plasticity in presenilin-1 conditional knockout mice. Neuron. 2001 Sep 13;31(5):713-26
• All: 45 reference(s)