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Phenotypes Associated with This Genotype
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phenotype observed in females
phenotype observed in males
N normal phenotype
• often exhibit scratching behavior suggestive of chronic pruritus

hematopoietic system
• large numbers of mast cells are present in and around the skin lesions

immune system
• large numbers of mast cells are present in and around the skin lesions

• no growth of pelage hair throughout life
• mice become completely hairless and smooth skinned in adulthood
• curly juvenile hair begins to appear thinly over the body starting at 5 days of age; lose juvenile hair progressively with age and become hairless by 12 weeks of age
• some hair follicle cysts filled with eosinophilic mass appear in the hypodermis within a few days after birth and increase in number and size until the 12th week of age
• thin vibrissae
• crooked vibrissae
• vibrissae are lost at around 12 weeks of age
• thickness of the dermis is increased due to proliferation of inflammatory cells and collagen bundles
• epidermis adjacent to lesions shows hyperkeratosis
• in regions of lesions
• in regions of lesions
• epidermis shows desquamation, with separation from the basal layer
• develop ulcerative skin lesions starting at 10 weeks of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
atopic dermatitis DOID:3310 OMIM:603165

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory