Phenotypes Associated with This Genotype

Genotype
MGI:2667689

• Allelic Composition: Noa/Noa⁺
• Genetic Background: NOA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

excessive scratching ( J:43274 )

• often exhibit scratching behavior suggestive of chronic pruritus

hematopoietic system

cutaneous mastocytosis ( J:43274 )

• large numbers of mast cells are present in and around the skin lesions

increased IgE level ( J:43274 )

immune system

cutaneous mastocytosis ( J:43274 )

• large numbers of mast cells are present in and around the skin lesions

increased IgE level ( J:43274 )

integument

abnormal hair growth ( J:43274 )

• no growth of pelage hair throughout life

hairless ( J:43274 )

• mice become completely hairless and smooth skinned in adulthood

progressive hair loss ( J:43274 )

• curly juvenile hair begins to appear thinly over the body starting at 5 days of age; lose juvenile hair progressively with age and become hairless by 12 weeks of age

abnormal hair follicle morphology ( J:43274 )

• some hair follicle cysts filled with eosinophilic mass appear in the hypodermis within a few days after birth and increase in number and size until the 12th week of age

abnormal vibrissa morphology ( J:43274 )

• thin vibrissae

kinked vibrissae ( J:43274 )

• crooked vibrissae

loss of vibrissae ( J:43274 )

• vibrissae are lost at around 12 weeks of age

thick dermal layer ( J:43274 )

• thickness of the dermis is increased due to proliferation of inflammatory cells and collagen bundles

hyperkeratosis ( J:43274 )

• epidermis adjacent to lesions shows hyperkeratosis

thick epidermis stratum granulosum ( J:43274 )

• in regions of lesions

thick epidermis stratum spinosum ( J:43274 )

• in regions of lesions

epidermal desquamation ( J:43274 )

• epidermis shows desquamation, with separation from the basal layer

spontaneous skin ulceration ( J:43274 )

• develop ulcerative skin lesions starting at 10 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
atopic dermatitis		DOID:3310	OMIM:603165 OMIM:PS603165	J:43274