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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Acaa1aem1Syki
endonuclease-mediated mutation 1, Soo-Youl Kim
MGI:8245457
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Acaa1aem1Syki/Acaa1a+ Not Specified MGI:8246630
cn2
 		Acaa1aem1Syki/Acaa1a+
Krastm4Tyj/Kras+
Trp53tm2Tyj/Trp53+
Tg(Pdx1-cre)6Tuv/0 		involves: 129S4/SvJae * C57BL/6 * FVB/N MGI:8246631


Genotype
MGI:8246630
ht1
Allelic
Composition		 Acaa1aem1Syki/Acaa1a+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acaa1aem1Syki mutation (0 available); any Acaa1a mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:371968 )
• heterozygous mice do not show any obvious phenotype under normal conditions




Genotype
MGI:8246631
cn2
Allelic
Composition		 Acaa1aem1Syki/Acaa1a+
Krastm4Tyj/Kras+
Trp53tm2Tyj/Trp53+
Tg(Pdx1-cre)6Tuv/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acaa1aem1Syki mutation (0 available); any Acaa1a mutation (19 available)
Krastm4Tyj mutation (11 available); any Kras mutation (68 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
Trp53tm2Tyj mutation (2 available); any Trp53 mutation (236 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased tumor-free survival time ( J:371968 )
• mice exhibit a median survival of 19 weeks, that is 3 weeks longer than that of KPC mice alone (Krastm4Tyj/Kras+ Trp53tm2Tyj/Trp53+ Tg(Pdx1-cre)6Tuv/0 mice that are wild-type for Acaa1a)
• at 22 weeks, the survival rate is 34% versus 0% observed in KPC mice alone, indicating an improvement in the overall survival of KPC mice

neoplasm
decreased tumor cell proliferation ( J:371968 )
• percentage of Ki-67 positive cells in pancreatic cancer tissue is significantly lower than that in KPC mice alone
decreased tumor growth/size ( J:371968 )
• immunohistochemical staining for Ki-67 in pancreatic cancer tissue indicates that the Ki-67-positive area is reduced by 96% relative to KPC mice alone, consistent with suppressed tumor growth

homeostasis/metabolism
enhanced autophagy ( J:371968 )
• average H-score for LC3-II in pancreatic cancer tissue is 2.3 times higher than that in KPC mice alone, suggesting increased autophagy

cellular
enhanced autophagy ( J:371968 )
• average H-score for LC3-II in pancreatic cancer tissue is 2.3 times higher than that in KPC mice alone, suggesting increased autophagy




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory