Acaa1a^em1Syki
Endonuclease-mediated Allele Detail

Summary

• Symbol: Acaa1a^em1Syki
• Name: acetyl-Coenzyme A acyltransferase 1A; endonuclease-mediated mutation 1, Soo-Youl Kim
• MGI ID: MGI:8245457
• Synonyms: Acaa1a^-
• Gene: Acaa1a Location: Chr9:119170113-119179361 bp, + strand Genetic Position: Chr9, 71.33 cM, cytoband F4
• Alliance: Acaa1a^em1Syki page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to generate an exon 3 deletion that causes a premature translational stop codon. This mutation produces a truncated protein consisting of only the N-terminal 88 amino acids of the full-length 424 amino acid wild-type protein. Western blot analysis demonstrated a >50% reduction of protein expression in heterozygous mutant mice. (J:371968)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acaa1a Mutation: 19 strains or lines available

References

• Original: J:371968 Lee H, et al., ACAA1 knockout increases the survival rate of KPC mice by activating autophagy. Mol Metab. 2025 Oct;100:102237
• All: 1 reference(s)