About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nudt21tm1.1Ejwpj
targeted mutation 1.1, Eric Wagner
MGI:6385854
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Foxd1tm1(GFP/cre)Amc/Foxd1+
Nudt21tm1.1Ejwpj/Nudt21tm1.1Ejwpj 		involves: 129S4/SvJae * C57BL/6 MGI:6386379
cn2
 		Nudt21tm1.1Ejwpj/Nudt21tm1.1Ejwpj
Tg(Col1a1-cre/ERT2)1Crm/0 		involves: C57BL/6J * CBA/J MGI:6386380


Genotype
MGI:6386379
cn1
Allelic
Composition		 Foxd1tm1(GFP/cre)Amc/Foxd1+
Nudt21tm1.1Ejwpj/Nudt21tm1.1Ejwpj
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxd1tm1(GFP/cre)Amc mutation (1 available); any Foxd1 mutation (11 available)
Nudt21tm1.1Ejwpj mutation (0 available); any Nudt21 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased susceptibility to injury ( J:283035 )
• bleomycin-treated mice once or repeatedly exhibit increased lung fibrosis compared with wild-type mice
• however, no increase in lethality is observed

respiratory system
pulmonary fibrosis ( J:283035 )
• increased in bleomycin-treated mice once or repeatedly




Genotype
MGI:6386380
cn2
Allelic
Composition		 Nudt21tm1.1Ejwpj/Nudt21tm1.1Ejwpj
Tg(Col1a1-cre/ERT2)1Crm/0
Genetic
Background		 involves: C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nudt21tm1.1Ejwpj mutation (0 available); any Nudt21 mutation (28 available)
Tg(Col1a1-cre/ERT2)1Crm mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased collagen level ( J:283035 )
• in the bronchial alveolar lavage fluid of bleomycin- and tamoxifen-treated mice once or repeatedly
increased susceptibility to injury ( J:283035 )
• bleomycin- and tamoxifen-treated mice exhibit increased collagen in bronchial alvealar lavage (BAL) fluid, alpha-SMA+ cells, total cell numbers (including macrophages and lymphocytes in the BAL), and exaggerated features of pulmonary fibrosis compared with wild-type mice
• however, late stage cellular inflammation and mortality are not affected

respiratory system
pulmonary fibrosis ( J:283035 )
• increased in bleomycin- and tamoxifen-treated mice once or repeatedly

immune system
increased acute inflammation ( J:283035 )
• in the early stages in the lungs of bleomycin- and tamoxifen-treated mice
• however, late stage cellular inflammation is not affected




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory