Phenotypes associated with this allele

• Allele Symbol: Lepr^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5692557
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lepr^tm1b(EUCOMM)Wtsi/Lepr^tm1b(EUCOMM)Wtsi	C57BL/6N-Lepr^tm1b(EUCOMM)Wtsi/H	MGI:5797628

Genotype
MGI:5797628

hm1

• Allelic Composition: Lepr^{tm1b(EUCOMM)Wtsi}/Lepr^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Lepr^{tm1b(EUCOMM)Wtsi}/H
• Cell Lines: EPD0548_5_G08

Data Sources

IMPC Data for Lepr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased total body fat amount ( J:211773 )

IMPC - HAR

behavior/neurological

decreased exploration in new environment ( J:211773 )

IMPC - HAR

increased anxiety-related response ( J:211773 )

IMPC - HAR

impaired righting response ( J:211773 )

IMPC - HAR

limb grasping ( J:211773 )

IMPC - HAR

tremors ( J:211773 )

IMPC - HAR

trunk curl ( J:211773 )

IMPC - HAR

abnormal locomotor behavior ( J:211773 )

IMPC - HAR

abnormal gait ( J:211773 )

IMPC - HAR

decreased locomotor activity ( J:211773 )

IMPC - HAR

cardiovascular system

decreased heart weight ( J:211773 )

IMPC - HAR

endocrine/exocrine glands

small seminal vesicle ( J:211773 )

♂

IMPC - HAR

growth/size/body

decreased lean body mass ( J:211773 )

IMPC - HAR

enlarged liver ( J:211773 )

IMPC - HAR

hematopoietic system

increased eosinophil cell number ( J:211773 )

IMPC - HAR

increased hematocrit ( J:211773 )

IMPC - HAR

increased hemoglobin content ( J:211773 )

IMPC - HAR

increased mean corpuscular hemoglobin ( J:211773 )

♂

IMPC - HAR

increased mean corpuscular volume ( J:211773 )

IMPC - HAR

increased red blood cell distribution width ( J:211773 )

IMPC - HAR

increased neutrophil cell number ( J:211773 )

IMPC - HAR

thrombocytopenia ( J:211773 )

♂

IMPC - HAR

increased mean platelet volume ( J:211773 )

♂

IMPC - HAR

increased monocyte cell number ( J:211773 )

♀

IMPC - HAR

decreased leukocyte cell number ( J:211773 )

♂

IMPC - HAR

decreased lymphocyte cell number ( J:211773 )

IMPC - HAR

decreased spleen weight ( J:211773 )

IMPC - HAR

homeostasis/metabolism

increased circulating fructosamine level ( J:211773 )

IMPC - HAR

increased circulating glucose level ( J:211773 )

IMPC - HAR

increased circulating cholesterol level ( J:211773 )

IMPC - HAR

increased circulating HDL cholesterol level ( J:211773 )

IMPC - HAR

decreased circulating triglyceride level ( J:211773 )

♀

IMPC - HAR

increased circulating calcium level ( J:211773 )

IMPC - HAR

increased circulating iron level ( J:211773 )

♀

IMPC - HAR

increased circulating phosphate level ( J:211773 )

IMPC - HAR

increased circulating potassium level ( J:211773 )

♀

IMPC - HAR

increased circulating alanine transaminase level ( J:211773 )

IMPC - HAR

increased circulating alkaline phosphatase level ( J:211773 )

IMPC - HAR

increased circulating amylase level ( J:211773 )

♂

IMPC - HAR

increased circulating aspartate transaminase level ( J:211773 )

IMPC - HAR

increased circulating serum albumin level ( J:211773 )

IMPC - HAR

increased circulating total protein level ( J:211773 )

IMPC - HAR

decreased circulating chloride level ( J:211773 )

IMPC - HAR

immune system

increased eosinophil cell number ( J:211773 )

IMPC - HAR

increased neutrophil cell number ( J:211773 )

IMPC - HAR

increased monocyte cell number ( J:211773 )

♀

IMPC - HAR

decreased leukocyte cell number ( J:211773 )

♂

IMPC - HAR

decreased lymphocyte cell number ( J:211773 )

IMPC - HAR

decreased spleen weight ( J:211773 )

IMPC - HAR

liver/biliary system

enlarged liver ( J:211773 )

IMPC - HAR

reproductive system

small seminal vesicle ( J:211773 )

♂

IMPC - HAR

female infertility ( J:211773 )

♀

IMPC - HAR

male infertility ( J:211773 )

♂

IMPC - HAR

skeleton

abnormal bone structure ( J:211773 )

♀

IMPC - HAR

decreased bone mineral content ( J:211773 )

IMPC - HAR

decreased bone mineral density ( J:211773 )

IMPC - HAR