All Phenotypes Brca1<tm3.1Rjbr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Brca1^tm3.1Rjbr
targeted mutation 3.1, Richard J Baer
MGI:5494435

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Brca1^tm3.1Rjbr/Brca1^tm3.1Rjbr	involves: 129 * C57BL/6	MGI:5494453
ht2	Brca1^tm2Arge/Brca1^tm3.1Rjbr	involves: 129 * C57BL/6	MGI:5494454
cn3	Brca1^tm2.1Cxd/Brca1^tm3.1Rjbr Trp53^tm3Tyj/Trp53⁺ Wap^tm1(cre)Arge/Wap⁺	involves: 129S1/Sv * 129S4/SvJae * 129S6/SvEvTac * C57BL/6	MGI:5494461
cn4	Brca1^tm2.1Cxd/Brca1^tm3.1Rjbr Wap^tm1(cre)Arge/Wap⁺	involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6	MGI:5494459
cn5	Brca1^tm1Thl/Brca1^tm3.1Rjbr Kras^tm4Tyj/Kras⁺ Trp53^tm1Thl/Trp53^tm1Thl Tg(Pdx1-cre)6Tuv/0	involves: 129S4/SvJae * C57BL/6 * FVB/N	MGI:5494462

Allelic Composition	Brca1^tm3.1Rjbr/Brca1^tm3.1Rjbr
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm3.1Rjbr mutation (1 available); any Brca1 mutation (113 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:177853 )

N	• mice are born at the expected Mendelian ratio and survived to adulthood

reproductive system

azoospermia ( J:177853 )

• seminiferous tubules lack elongated spermatids and spermatozoa

small testis ( J:177853 )

arrest of spermatogenesis ( J:177853 )

male infertility ( J:177853 )

growth/size/body

decreased body weight ( J:177853 )

• modest

cellular

cellular phenotype ( J:177853 )

N	• mouse embryonic fibroblasts exhibit normal cellular proliferation, chromosomal stability, senescence induction, centrosome number, spindle formation, resistance to genotoxic stress and ubiquitin foci formation at sites of DNA damage

azoospermia ( J:177853 )

• seminiferous tubules lack elongated spermatids and spermatozoa

neoplasm

neoplasm ( J:177853 )

N	• mice do not exhibit increased spontaneous tumor formation

endocrine/exocrine glands

small testis ( J:177853 )

Allelic Composition	Brca1^tm2Arge/Brca1^tm3.1Rjbr
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm2Arge mutation (0 available); any Brca1 mutation (113 available)
Brca1^tm3.1Rjbr mutation (1 available); any Brca1 mutation (113 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:177853 )

N	• mice do not exhibit increased spontaneous tumor formation

Allelic Composition	Brca1^tm2.1Cxd/Brca1^tm3.1Rjbr Trp53^tm3Tyj/Trp53⁺ Wap^tm1(cre)Arge/Wap⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm2.1Cxd mutation (1 available); any Brca1 mutation (113 available)
Brca1^tm3.1Rjbr mutation (1 available); any Brca1 mutation (113 available)
Trp53^tm3Tyj mutation (3 available); any Trp53 mutation (232 available)
Wap^tm1(cre)Arge mutation (0 available); any Wap mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor latency ( J:177853 )

• compared with Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Trp53^tm3Tyj/Trp53^tm3Tyj Wap^tm1(cre)Arge/Wap^tm1(cre)Arge

Allelic Composition	Brca1^tm2.1Cxd/Brca1^tm3.1Rjbr Wap^tm1(cre)Arge/Wap⁺
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm2.1Cxd mutation (1 available); any Brca1 mutation (113 available)
Brca1^tm3.1Rjbr mutation (1 available); any Brca1 mutation (113 available)
Wap^tm1(cre)Arge mutation (0 available); any Wap mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:177853 )

N	• unlike in mice with Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Wap^tm1(cre)Arge/Wap⁺, mice remain tumor free over a 24-month observation period

Allelic Composition	Brca1^tm1Thl/Brca1^tm3.1Rjbr Kras^tm4Tyj/Kras⁺ Trp53^tm1Thl/Trp53^tm1Thl Tg(Pdx1-cre)6Tuv/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm1Thl mutation (1 available); any Brca1 mutation (113 available)
Brca1^tm3.1Rjbr mutation (1 available); any Brca1 mutation (113 available)
Kras^tm4Tyj mutation (9 available); any Kras mutation (76 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
Trp53^tm1Thl mutation (0 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor latency ( J:177853 )

• as in Kras^tm4Tyj/Kras⁺ Tg(Ipf1-cre)6Tuv Trp53^tm1Thl/Trp53^tm1Thlmice succumb to pancreatic tumors with an average latency of 65 days

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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