Phenotypes associated with this allele

• Allele Symbol: Igs2⁺
• Allele Name: wild type
• Allele ID: MGI:5461155
• Summary: 10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Igs2^em1(Rnu6-RNAi:mt-Cytb)Lixg/Igs2^+	involves: C57BL/6J	MGI:8220147
ht2	Igs2^em1(Alb-Golm1)Jdon/Igs2^+	involves: C57BL/6N	MGI:6718457
cn3	Igs2^tm1(CAG-Met)Zsu/Igs2^+ Pten^tm1Hwu/Pten^tm1Hwu Tg(Pbsn-cre)4Prb/0	involves: 129 * C57BL/6 * DBA/2 * FVB/N	MGI:6507866
cn4	Igs2^tm1(CAG-Met)Zsu/Igs2^+ Tg(Pbsn-cre)4Prb/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 * FVB/N	MGI:6507865
cn5	Ctnnb1^tm1Mmt/Ctnnb1^+ Igs2^tm1(CAG-Met)Zsu/Igs2^+ Tg(Pbsn-cre)4Prb/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 * FVB/N	MGI:6507888
cn6	Kansl1^em1Cya/Kansl1^em1Cya Tg(CAG-cre/Esr1*)5Amc/0 Igs2^tm1(CAG-mt-Keima)Fink/Igs2^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA * FVB/N	MGI:7763627
cn7	Igs2^em53(Myh6-cre/ERT2)Gpt/Igs2^+ Stx17^em1Gpt/Stx17^em1Gpt	involves: C57BL/6JGpt	MGI:7608030
cn8	Kansl1^em1Cya/Kansl1^+ Tg(CAG-cre/Esr1*)5Amc/0 Igs2^tm1(CAG-mt-Keima)Fink/Igs2^+	Not Specified	MGI:7763629
cx9	Igs2^tm1(CAG-mt-Keima)Fink/Igs2^+ Lamp2^tm1Psa/Lamp2^tm1Psa	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	MGI:6259616
cx10	Igs2^tm1(CAG-mt-Keima)Fink/Igs2^+ Kansl1^em1.1Cya/Kansl1^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N	MGI:7763626

Genotype
MGI:8220147

ht1

• Allelic Composition: Igs2^{em1(Rnu6-RNAi:mt-Cytb)Lixg}/Igs2⁺
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal ovarian follicle number ( J:365610 )

♀ • decreased number of follicles, but no change in the ratio of primordial, growing, mature, and atretic follicles

reproductive system

abnormal ovarian follicle number ( J:365610 )

♀ • decreased number of follicles, but no change in the ratio of primordial, growing, mature, and atretic follicles

reduced female fertility ( J:365610 )

♀ • reduced litter sizes when females are crossed to wild-type males

♀ • however, male fertility is similar to wild-type

decreased litter size ( J:365610 )

♀ • when females are crossed to wild-type males

Genotype
MGI:6718457

ht2

• Allelic Composition: Igs2^{em1(Alb-Golm1)Jdon}/Igs2⁺
• Genetic Background: involves: C57BL/6N

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:306528 )

♂ • mice show a higher hepatocellular carcinoma incidence, heavier liver to body weight ratio and larger tumor diameter following induction with DEN/CCl4

♂ • DEN/CCl4-induced mice show a reduction in CD8+ T cell numbers and an induction of tumor-associated macrophages in tumors

increased susceptibility to injury ( J:306528 )

♂ • in a CCl4-induced liver injury model, mice show more severe inflammation, liver function injury, and liver fibrosis than wild-type mice

neoplasm

increased incidence of tumors by chemical induction ( J:306528 )

♂ • mice show a higher hepatocellular carcinoma incidence, heavier liver to body weight ratio and larger tumor diameter following induction with DEN/CCl4

♂ • DEN/CCl4-induced mice show a reduction in CD8+ T cell numbers and an induction of tumor-associated macrophages in tumors

immune system

decreased CD8-positive, alpha-beta T cell number ( J:306528 )

♂ • DEN/CCl4-induced mice show a reduction in CD8+ T cell numbers

♂ • however, no changes in percentages of other immune cells, including regulatory T cells, CD4+ T cells, B cells, and natural killer cells are seen in DEN/CCl4-induced mice

hematopoietic system

decreased CD8-positive, alpha-beta T cell number ( J:306528 )

♂ • DEN/CCl4-induced mice show a reduction in CD8+ T cell numbers

♂ • however, no changes in percentages of other immune cells, including regulatory T cells, CD4+ T cells, B cells, and natural killer cells are seen in DEN/CCl4-induced mice

Genotype
MGI:6507866

cn3

• Allelic Composition: Igs2^{tm1(CAG-Met)Zsu}/Igs2⁺; Pten^tm1Hwu/Pten^tm1Hwu; Tg(Pbsn-cre)4Prb/0
• Genetic Background: involves: 129 * C57BL/6 * DBA/2 * FVB/N

endocrine/exocrine glands

increased prostate gland tumor incidence ( J:268934 )

♂ • mice develop prostatic sarcomatoid carcinoma

♂ • mice show a more aggressive prostatic tumor phenotype than single conditional Pten^tm1Hwu mice

increased prostate gland adenocarcinoma incidence ( J:268934 )

♂ • mice develop prostatic adenocarcinomas and invasive carcinomas

increased prostate intraepithelial neoplasia incidence ( J:268934 )

♂ • 5 of 5 mice develop multifocal high grade intraepithelial neoplasia (PIN) before 4 months of age

neoplasm

increased prostate gland tumor incidence ( J:268934 )

♂ • mice develop prostatic sarcomatoid carcinoma

♂ • mice show a more aggressive prostatic tumor phenotype than single conditional Pten^tm1Hwu mice

increased prostate gland adenocarcinoma incidence ( J:268934 )

♂ • mice develop prostatic adenocarcinomas and invasive carcinomas

increased prostate intraepithelial neoplasia incidence ( J:268934 )

♂ • 5 of 5 mice develop multifocal high grade intraepithelial neoplasia (PIN) before 4 months of age

increased metastatic potential ( J:268934 )

♂ • prostate cancer metastasis after 10 months of age with 62.5% of mice showing metastatic lesions

♂ • metastasis to lungs and periprostatic lymph nodes is seen

♂ • mice show an overall more invasive tumor phenotype than single conditional Pten^tm1Hwu mice

increased carcinoma incidence ( J:268934 )

♂ • 1 of 5 mice show invasive pancreatic carcinoma at 4-10 months and 6 of 8 mice develop invasive carcinoma after 10 months of age; 5 of 8 mice have invasive carcinoma with epithelial-mesenchymal transition and 5 of 8 mice have invasive carcinoma with metastasis

♂ • mice exhibit a transition from prostatic adenocarcinoma and invasive carcinoma lesions to pathology resembling prostatic sarcamoid carcinomas

♂ • sarcamoid carcinomas show spindle-like tumor cells, tumor cells with a multitude of mitotic figures, and haphazard acini and lobules of pleomorphic cells, indicating that these lesions possess mesenchymal morphology and proliferative and invasive features

reproductive system

increased prostate gland tumor incidence ( J:268934 )

♂ • mice develop prostatic sarcomatoid carcinoma

♂ • mice show a more aggressive prostatic tumor phenotype than single conditional Pten^tm1Hwu mice

increased prostate gland adenocarcinoma incidence ( J:268934 )

♂ • mice develop prostatic adenocarcinomas and invasive carcinomas

increased prostate intraepithelial neoplasia incidence ( J:268934 )

♂ • 5 of 5 mice develop multifocal high grade intraepithelial neoplasia (PIN) before 4 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:268934

Genotype
MGI:6507865

cn4

• Allelic Composition: Igs2^{tm1(CAG-Met)Zsu}/Igs2⁺; Tg(Pbsn-cre)4Prb/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 * FVB/N

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:268934 )

N • mice do not show any obvious pathological changes in prostate tissues from birth to 20 months of age

increased prostate intraepithelial neoplasia incidence ( J:268934 )

• mice administered recombinant human hepatocyte growth factor at 6 months of age show lesions of typical low-grade prostatic intraepithelial neoplasia not seen in hepatocyte growth factor-administered wild-type mice

• however, hepatocyte growth factor-administered mice do not develop prostate carcinomas

reproductive system

increased prostate intraepithelial neoplasia incidence ( J:268934 )

• mice administered recombinant human hepatocyte growth factor at 6 months of age show lesions of typical low-grade prostatic intraepithelial neoplasia not seen in hepatocyte growth factor-administered wild-type mice

• however, hepatocyte growth factor-administered mice do not develop prostate carcinomas

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:268934 )

• mice administered recombinant human hepatocyte growth factor at 6 months of age show lesions of typical low-grade prostatic intraepithelial neoplasia not seen in hepatocyte growth factor-administered wild-type mice

• however, hepatocyte growth factor-administered mice do not develop prostate carcinomas

Genotype
MGI:6507888

cn5

• Allelic Composition: Ctnnb1^tm1Mmt/Ctnnb1⁺; Igs2^{tm1(CAG-Met)Zsu}/Igs2⁺; Tg(Pbsn-cre)4Prb/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 * FVB/N

endocrine/exocrine glands

increased prostate gland adenocarcinoma incidence ( J:284956 )

♂ • mice develop aggressive adenocarcinomas that occur with much higher frequency than in single Ctnnb1^tm1Mmt conditional mutants, developing prostatic invasive adenocarcinomas as early as 7 months of age

♂ • 4 of 4 mice show intracystic adenocarcinoma at 6-9 months of age, with 1 of 4 mice showing invasive adenocarcinoma

♂ • 13 of 13 mice show intracystic adenocarcinoma at 9 months or older, with 5 of 13 showing invasive adenocarcinoma

increased prostate intraepithelial neoplasia incidence ( J:284956 )

♂ • mice develop PIN lesions starting at 4-6 weeks of age, with 5 of 5 mice showing high grade PIN before 6 months of age

♂ • mice develop more severe PIN lesions and faster disease progression than single Ctnnb1^tm1Mmt conditional mutants

♂ • lesions in the anterior, dorsal, and lateral prostate lobes are more severe than in the ventral prostate

♂ • typical cribriform and papilliferous structures completely fill the lumen of prostatic glands

neoplasm

increased prostate gland adenocarcinoma incidence ( J:284956 )

♂ • mice develop aggressive adenocarcinomas that occur with much higher frequency than in single Ctnnb1^tm1Mmt conditional mutants, developing prostatic invasive adenocarcinomas as early as 7 months of age

♂ • 4 of 4 mice show intracystic adenocarcinoma at 6-9 months of age, with 1 of 4 mice showing invasive adenocarcinoma

♂ • 13 of 13 mice show intracystic adenocarcinoma at 9 months or older, with 5 of 13 showing invasive adenocarcinoma

increased prostate intraepithelial neoplasia incidence ( J:284956 )

♂ • mice develop PIN lesions starting at 4-6 weeks of age, with 5 of 5 mice showing high grade PIN before 6 months of age

♂ • mice develop more severe PIN lesions and faster disease progression than single Ctnnb1^tm1Mmt conditional mutants

♂ • lesions in the anterior, dorsal, and lateral prostate lobes are more severe than in the ventral prostate

♂ • typical cribriform and papilliferous structures completely fill the lumen of prostatic glands

reproductive system

increased prostate gland adenocarcinoma incidence ( J:284956 )

♂ • mice develop aggressive adenocarcinomas that occur with much higher frequency than in single Ctnnb1^tm1Mmt conditional mutants, developing prostatic invasive adenocarcinomas as early as 7 months of age

♂ • 4 of 4 mice show intracystic adenocarcinoma at 6-9 months of age, with 1 of 4 mice showing invasive adenocarcinoma

♂ • 13 of 13 mice show intracystic adenocarcinoma at 9 months or older, with 5 of 13 showing invasive adenocarcinoma

increased prostate intraepithelial neoplasia incidence ( J:284956 )

♂ • mice develop PIN lesions starting at 4-6 weeks of age, with 5 of 5 mice showing high grade PIN before 6 months of age

♂ • mice develop more severe PIN lesions and faster disease progression than single Ctnnb1^tm1Mmt conditional mutants

♂ • lesions in the anterior, dorsal, and lateral prostate lobes are more severe than in the ventral prostate

♂ • typical cribriform and papilliferous structures completely fill the lumen of prostatic glands

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:284956

Genotype
MGI:7763627

cn6

• Allelic Composition: Kansl1^em1Cya/Kansl1^em1Cya; Tg(CAG-cre/Esr1*)5Amc/0; Igs2^{tm1(CAG-mt-Keima)Fink}/Igs2⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA * FVB/N

cellular

abnormal mitophagy ( J:327464 )

• hippocampal neurons treated with tamoxifen exhibit low mitophagic activity at 7 days in vitro

homeostasis/metabolism

abnormal mitophagy ( J:327464 )

• hippocampal neurons treated with tamoxifen exhibit low mitophagic activity at 7 days in vitro

Genotype
MGI:7608030

cn7

• Allelic Composition: Igs2^{em53(Myh6-cre/ERT2)Gpt}/Igs2⁺; Stx17^em1Gpt/Stx17^em1Gpt
• Genetic Background: involves: C57BL/6JGpt

cardiovascular system

abnormal heart morphology ( J:345305 )

• high-fat diet induced cardiac fibrosis is alleviated in tamoxifen treated mice

• no abnormalities in cardiac morphology in tamoxifen treated mice on a normal diet

abnormal myocardial fiber morphology ( J:345305 )

• high-fat diet induced increase in cardiomyocyte cross-sectional are is alleviated in tamoxifen treated mice

abnormal cardiovascular system physiology ( J:345305 )

• alleviation of high-fat diet induced cardiac oxidative stress and lipid peroxidation in tamoxifen treated mice

abnormal cardiac muscle contractility ( J:345305 )

• reduction in the high-fat diet induced decreases in ejection fraction and fractional shortening in tamoxifen treated mice

growth/size/body

growth/size/body region phenotype ( J:345305 )

N • no difference in body weight in tamoxifen treated mice on a high fat diet compared to diet matched controls

muscle

abnormal myocardial fiber morphology ( J:345305 )

• high-fat diet induced increase in cardiomyocyte cross-sectional are is alleviated in tamoxifen treated mice

abnormal cardiac muscle contractility ( J:345305 )

• reduction in the high-fat diet induced decreases in ejection fraction and fractional shortening in tamoxifen treated mice

Genotype
MGI:7763629

cn8

• Allelic Composition: Kansl1^em1Cya/Kansl1⁺; Tg(CAG-cre/Esr1*)5Amc/0; Igs2^{tm1(CAG-mt-Keima)Fink}/Igs2⁺
• Genetic Background: Not Specified

cellular

abnormal mitophagy ( J:327464 )

• hippocampal neurons treated with tamoxifen exhibit low mitophagic activity at 7 days in vitro

• infection of lentiviral Stx17 into tamoxifen-treated neurons leads to partial restoration of mitophagic activity

homeostasis/metabolism

abnormal mitophagy ( J:327464 )

• hippocampal neurons treated with tamoxifen exhibit low mitophagic activity at 7 days in vitro

• infection of lentiviral Stx17 into tamoxifen-treated neurons leads to partial restoration of mitophagic activity

Genotype
MGI:6259616

cx9

• Allelic Composition: Igs2^{tm1(CAG-mt-Keima)Fink}/Igs2⁺; Lamp2^tm1Psa/Lamp2^tm1Psa
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

cardiovascular system

abnormal myocardial fiber physiology ( J:253728 )

♀ • cardiomyocytes from 20 week old mice exhibit impaired delivery of damaged mitochondria to the lysosomes for degradation and increased accumulation of damaged mitochondria in the cytoplasm and within autophagic vacuoles

cellular

abnormal mitophagy ( J:253728 )

♀ • cardiomyocytes from 20 week old mice exhibit impaired delivery of damaged mitochondria to the lysosomes for degradation and increased accumulation of damaged mitochondria in the cytoplasm and within autophagic vacuoles

homeostasis/metabolism

abnormal mitophagy ( J:253728 )

♀ • cardiomyocytes from 20 week old mice exhibit impaired delivery of damaged mitochondria to the lysosomes for degradation and increased accumulation of damaged mitochondria in the cytoplasm and within autophagic vacuoles

muscle

abnormal myocardial fiber physiology ( J:253728 )

♀ • cardiomyocytes from 20 week old mice exhibit impaired delivery of damaged mitochondria to the lysosomes for degradation and increased accumulation of damaged mitochondria in the cytoplasm and within autophagic vacuoles

Genotype
MGI:7763626

cx10

• Allelic Composition: Igs2^{tm1(CAG-mt-Keima)Fink}/Igs2⁺; Kansl1^em1.1Cya/Kansl1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

cellular

abnormal mitophagy ( J:327464 )

• basal mitophagic levels of hippocampus and heart are reduced

homeostasis/metabolism

abnormal mitophagy ( J:327464 )

• basal mitophagic levels of hippocampus and heart are reduced