Igs2^{em1(Rnu6-RNAi:mt-Cytb)Lixg}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Igs2^{em1(Rnu6-RNAi:mt-Cytb)Lixg}
• Name: intergenic site 2; endonuclease-mediated mutation 1, Xingguo Liu
• MGI ID: MGI:8220101
• Synonyms: H11^sh187
• Gene: Igs2 Location: Chr11:3195460-3195497 bp Genetic Position: Chr11, Syntenic
• Alliance: Igs2^{em1(Rnu6-RNAi:mt-Cytb)Lixg} page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Knockdown, Modified isoform(s))
• Mutation: Insertion
• Igs2^{em1(Rnu6-RNAi:mt-Cytb)Lixg} involves 1 genes/genome features (mt-Cytb) View all
• Mutation details: CRISPR/cas9 mediated recombination inserted a U6-shCytb-187AA-polyT construct. This construct is designed to knockdown expression of an 187 amino acid long protein encoded by mt-Cytb but translated in the cytosol not the mitochondria. (J:365610)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igs2 Mutation: 72 strains or lines available

References

• Original: J:365610 Hu Z, et al., A novel protein CYTB-187AA encoded by the mitochondrial gene CYTB modulates mammalian early development. Cell Metab. 2024 Apr 29
• All: 1 reference(s)