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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Igs2em1(Rnu6-RNAi:mt-Cytb)Lixg
endonuclease-mediated mutation 1, Xingguo Liu
MGI:8220101
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Igs2em1(Rnu6-RNAi:mt-Cytb)Lixg/Igs2em1(Rnu6-RNAi:mt-Cytb)Lixg involves: C57BL/6J MGI:8220148
ht2
 		Igs2em1(Rnu6-RNAi:mt-Cytb)Lixg/Igs2+ involves: C57BL/6J MGI:8220147


Genotype
MGI:8220148
hm1
Allelic
Composition		 Igs2em1(Rnu6-RNAi:mt-Cytb)Lixg/Igs2em1(Rnu6-RNAi:mt-Cytb)Lixg
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igs2em1(Rnu6-RNAi:mt-Cytb)Lixg mutation (0 available); any Igs2 mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal ovarian follicle number ( J:365610 )
• decreased number of follicles, but no change in the ratio of primordial, growing, mature, and atretic follicles
reduced female fertility ( J:365610 )
• reduced litter sizes when females are crossed to wild-type males
• however, male fertility is similar to wild-type
decreased litter size ( J:365610 )
• when females are crossed to wild-type males

endocrine/exocrine glands
abnormal ovarian follicle number ( J:365610 )
• decreased number of follicles, but no change in the ratio of primordial, growing, mature, and atretic follicles




Genotype
MGI:8220147
ht2
Allelic
Composition		 Igs2em1(Rnu6-RNAi:mt-Cytb)Lixg/Igs2+
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igs2em1(Rnu6-RNAi:mt-Cytb)Lixg mutation (0 available); any Igs2 mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal ovarian follicle number ( J:365610 )
• decreased number of follicles, but no change in the ratio of primordial, growing, mature, and atretic follicles

reproductive system
abnormal ovarian follicle number ( J:365610 )
• decreased number of follicles, but no change in the ratio of primordial, growing, mature, and atretic follicles
reduced female fertility ( J:365610 )
• reduced litter sizes when females are crossed to wild-type males
• however, male fertility is similar to wild-type
decreased litter size ( J:365610 )
• when females are crossed to wild-type males




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory