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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm3(CAG-flpo/ERT2)Alj
targeted mutation 3, Alexandra L Joyner
MGI:5432216
Summary 4 genotypes


Genotype
MGI:5432788
hm1
Allelic
Composition		 Gt(ROSA)26Sortm3(CAG-flpo/ERT2)Alj/Gt(ROSA)26Sortm3(CAG-flpo/ERT2)Alj
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm3(CAG-flpo/ERT2)Alj mutation (2 available); any Gt(ROSA)26Sor mutation (942 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:186310 )
• mice are viable and fertile with no reported phenotypic abnormalities




Genotype
MGI:6286134
cn2
Allelic
Composition		 Gt(ROSA)26Sortm3(CAG-flpo/ERT2)Alj/Gt(ROSA)26Sor+
Npm1tm1Trow/Npm1+
Genetic
Background		 B6.Cg-Gt(ROSA)26Sortm3(CAG-flpo/ERT2)Alj Npm1tm1Trow
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm3(CAG-flpo/ERT2)Alj mutation (2 available); any Gt(ROSA)26Sor mutation (942 available)
Npm1tm1Trow mutation (1 available); any Npm1 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal bone marrow hematopoietic cell morphology ( J:272803 )
• increase in total number of colony forming units are found in whole bone marrow cells 4 months post-tamoxifen injection
increased granulocyte monocyte progenitor cell number ( J:272803 )
• expansion of granulocyte and granulocyte-macrophage colony types are found in whole bone marrow cells 4 months post-tamoxifen injection
decreased hematopoietic stem cell number ( J:272803 )
• decrease in frequency and total number of long term hematopoietic stem cells 4 months post-tamoxifen injection
• decrease in total number of short term hematopoietic stem cells 4 months post-tamoxifen injection
abnormal bone marrow cell physiology ( J:272803 )
• bone marrow cells transplanted into lethally irradiated recipients and treated with pIpC and tamoxifen results in death in a 29% of animals in a 440 day period due to myeloproliferative disorder




Genotype
MGI:6286136
cn3
Allelic
Composition		 Dnmt3atm1Trow/Dnmt3a+
Gt(ROSA)26Sortm3(CAG-flpo/ERT2)Alj/Gt(ROSA)26Sor+
Npm1tm1Trow/Npm1+
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 B6.Cg-Gt(ROSA)26Sortm3(CAG-flpo/ERT2)Alj Npm1tm1Trow Dnmt3atm1Trow Tg(Mx1-cre)1Cgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt3atm1Trow mutation (1 available); any Dnmt3a mutation (138 available)
Gt(ROSA)26Sortm3(CAG-flpo/ERT2)Alj mutation (2 available); any Gt(ROSA)26Sor mutation (942 available)
Npm1tm1Trow mutation (1 available); any Npm1 mutation (33 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal bone marrow cell physiology ( J:272803 )
• bone marrow cells transplanted into lethally irradiated recipients and treated with pIpC and tamoxifen results in death in a 100% of animals in a 440 day period
• in 33% of mice death is the result of myeloproliferative disorder (MPD)
• in 67% of mice death is the result of mixed myelodysplastic syndrome and myeloproliferative disorder (MDS/MPD)
• bone marrow cells from MDS/MPD or MPD primary transplants transplanted into sublethally irradiated secondary recipients results in 100% lethality due to acute myeloid leukemia (AML)




Genotype
MGI:5474767
cn4
Allelic
Composition		 Smarce1tm1Tich/Smarce1tm2.1Tich
Gt(ROSA)26Sortm3(CAG-flpo/ERT2)Alj/Gt(ROSA)26Sor+
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm3(CAG-flpo/ERT2)Alj mutation (2 available); any Gt(ROSA)26Sor mutation (942 available)
Smarce1tm1Tich mutation (0 available); any Smarce1 mutation (28 available)
Smarce1tm2.1Tich mutation (0 available); any Smarce1 mutation (28 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:194195 )
N
• tamoxifen-treated mice exhibit no gross functional defects in mature T cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory