Phenotypes associated with this allele

• Allele Symbol: Rdh10^tm1.1Ics
• Allele Name: targeted mutation 1.1, Mouse Clinical Institute
• Allele ID: MGI:5294926
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rdh10^tm1.1Ics/Rdh10^tm1.1Ics	involves: C57BL/6 * SJL	MGI:5294947

Genotype
MGI:5294947

hm1

• Allelic Composition: Rdh10^tm1.1Ics/Rdh10^tm1.1Ics
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Morphological abnormalities of Rdh10^tm1.1Ics/Rdh10^tm1.1Ics and Rdh10^tm2Ics/Rdh10^tm2Ics embryos

mortality/aging

lethality during fetal growth through weaning, complete penetrance ( J:177362 )

• no mice are recovered postnatally

embryonic lethality during organogenesis, complete penetrance ( J:177362 )

• some mice die between E10.5 and E12.5

• however, long-term supplementation of maternal diet with retinaldehyde survive postnatally

embryo

embryo phenotype ( J:177362 )

N • supplementation of maternal diet with retinaldehyde rescues embryonic defects

embryo tissue necrosis ( J:177362 )

• embryos are sometimes necrotic at E10.5

abnormal pharyngeal arch morphology ( J:177362 )

• posterior to second arches

abnormal embryo development ( J:177362 )

• compacted cervical/upper trunk region at E9-E9.5

• supplementation of maternal diet with retinoic acid partially rescues embryonic defects

incomplete embryo turning ( J:177362 )

abnormal mesoderm development ( J:177362 )

• cervical mesoderm patterning is abnormal

caudal body truncation ( J:177362 )

• at E9-E9.5

embryonic growth retardation ( J:177362 )

• at E10.5

small forelimb buds ( J:177362 )

• forelimb buds are hypoplastic or almost undetectable

cardiovascular system

persistent truncus arteriosus ( J:177362 )

abnormal heart development ( J:177362 )

• hearts exhibit no distinct left-right atria, misaligned putative ventricles, and poor myocardial trabeculation

abnormal heart tube morphology ( J:177362 )

abnormal cardiovascular system physiology ( J:177362 )

• mice exhibit abnormal blood stasis suggesting cardiovascular failure

craniofacial

abnormal craniofacial development ( J:177362 )

• truncated nasal process

abnormal pharyngeal arch morphology ( J:177362 )

• posterior to second arches

facial cleft ( J:177362 )

• severe nasal/facial clefting at E12.5

limbs/digits/tail

abnormal limb morphology ( J:177362 )

• after long-term retinaldehyde treatment, mice exhibit distal limb defects with shortened digits and soft tissue syndactyly particularly evident for hindlimb digits

small forelimb buds ( J:177362 )

• forelimb buds are hypoplastic or almost undetectable

brachydactyly ( J:177362 )

• in mice rescued by long-term retinaldehyde treatment particularly evident for hindlimb digits

syndactyly ( J:177362 )

• in mice rescued by long-term retinaldehyde treatment particularly evident for hindlimb digits

vision/eye

small lens ( J:177362 )

abnormal eye development ( J:177362 )

• despite developing intracranially, eyes are not visible at E12.5

decreased ventral retina size ( J:177362 )

hearing/vestibular/ear

abnormal otic vesicle morphology ( J:177362 )

• small, sometimes duplicated

small otic vesicle ( J:177362 )

digestive/alimentary system

abnormal intestine morphology ( J:177362 )

• poor morphological differentiation

abnormal stomach morphology ( J:177362 )

• poor morphological differentiation

growth/size/body

facial cleft ( J:177362 )

• severe nasal/facial clefting at E12.5

embryonic growth retardation ( J:177362 )

• at E10.5

behavior/neurological

circling ( J:177362 )

• in mice rescued by long-term retinaldehyde treatment

endocrine/exocrine glands

pancreas hypoplasia ( J:177362 )

liver/biliary system

liver hypoplasia ( J:177362 )

nervous system

abnormal hindbrain development ( J:177362 )

renal/urinary system

renal hypoplasia ( J:177362 )

respiratory system

absent lungs ( J:177362 )

cellular

embryo tissue necrosis ( J:177362 )

• embryos are sometimes necrotic at E10.5