Rdh10tm1.1Ics
Targeted Allele Detail
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Symbol: |
Rdh10tm1.1Ics |
Name: |
retinol dehydrogenase 10 (all-trans); targeted mutation 1.1, Mouse Clinical Institute |
MGI ID: |
MGI:5294926 |
Synonyms: |
Rdh10L- |
Gene: |
Rdh10 Location: Chr1:16176106-16202774 bp, + strand Genetic Position: Chr1, 4.94 cM
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Alliance: |
Rdh10tm1.1Ics page
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Shorter digits and soft tissue hindlimb syndactyly in Rdh10tm1.1Ics/Rdh10tm1.1Ics and Rdh10tm2Ics/Rdh10tm2Ics adults
Show the 3 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:177362
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Insertion
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Mutation details: Cre-mediated recombination removed exons 3 and 4. This deletion removes three residues that are indispensible for catalytic activity.
(J:177362)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Rdh10 Mutation: |
20 strains or lines available
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Original: |
J:177362 Rhinn M, et al., Involvement of retinol dehydrogenase 10 in embryonic patterning and rescue of its loss of function by maternal retinaldehyde treatment. Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16687-92 |
All: |
5 reference(s) |
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