Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncstntm1.1Akli mutation
(0 available);
any
Ncstn mutation
(33 available)
Tg(VAV1-cre)1Graf mutation
(1 available)
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mortality/aging
immune system
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• splenocytes transplanted into lethally irradiated recipients induce increased myeloid cell counts in peripheral blood compared with cells from control mice
• however, transplanted cells do not induce lethal myeloid leukemia
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hematopoietic system
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• splenocytes transplanted into lethally irradiated recipients induce increased myeloid cell counts in peripheral blood compared with cells from control mice
• however, transplanted cells do not induce lethal myeloid leukemia
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growth/size/body
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncstntm1.1Akli mutation
(0 available);
any
Ncstn mutation
(33 available)
Tg(Upk2-cre,-EGFP)#Akli mutation
(0 available)
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neoplasm
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• within 2-6 months of age, mice develop bladder tumors that consist of simple and nodular hyperplasia, as well as high-grade dysplasia and carcinoma in situ showing basal characteristics
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renal/urinary system
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• within 2-6 months of age, mice develop bladder tumors that consist of simple and nodular hyperplasia, as well as high-grade dysplasia and carcinoma in situ showing basal characteristics
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• mice develop occasional unilateral hydronephrosis within 2-6 months due to ureter obstruction
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1.1(rtTA2S*M2)Whsu mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Ncstntm1.1Akli mutation
(0 available);
any
Ncstn mutation
(33 available)
Tg(tetO-cre)1Jaw mutation
(5 available)
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neoplasm
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• doxycycline (dox) treated mice rapidly develop invasive urothelial cancer
• tumors of dox treated mice are high-grade urothelial carcinomas, grow mostly with a solid, non-glandular pattern and show blunt cellular atypia and focal glandular differentiation
• tumors invade the lamina and muscularis propria
• marker analysis indicates that tumors are related to human basal BLCA3 subtype
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renal/urinary system
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• doxycycline (dox) treated mice rapidly develop invasive urothelial cancer
• tumors of dox treated mice are high-grade urothelial carcinomas, grow mostly with a solid, non-glandular pattern and show blunt cellular atypia and focal glandular differentiation
• tumors invade the lamina and muscularis propria
• marker analysis indicates that tumors are related to human basal BLCA3 subtype
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• 12 of 18 mice develop unilateral or bilateral hydronephrosis as early as 2 weeks after dox treatment due to obstruction of the upper ureter by tumor masses
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• due to bladder tumors in dox treated mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncstntm1.1Akli mutation
(0 available);
any
Ncstn mutation
(33 available)
Tg(Mx1-cre)1Cgn mutation
(7 available)
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mortality/aging
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• do not survive more than 20 weeks after induction of cre mediated recombination
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hematopoietic system
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• significant reduction of the lymphoid-biased multipotential progenitor population (L-MPP) after induction of cre mediated recombination
• striking increase in the absolute numbers of both bone marrow and spleen granulocyte/monocyte progenitors cells after induction of cre mediated recombination
• decrease of the megakaryocyte?erythrocyte progenitor population after induction of cre mediated recombination
• progenitor cells display an increase in their self-renewal capacity after induction of cre mediated recombination
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• striking peripheral blood leukocytosis after induction of cre mediated recombination
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• striking peripheral blood monocytosis after induction of cre mediated recombination
• increase in monocyte numbers in the bone marrow and liver after induction of cre mediated recombination
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• de-repression of an extended myeloid-specific program in LSK cells
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• increase in LSK numbers after induction of cre mediated recombination
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• expansion of the red pulp with diffuse infiltration by myeloid and monocytic cells after induction of cre mediated recombination
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• after induction of cre mediated recombination
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• expansion of the red pulp after induction of cre mediated recombination
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neoplasm
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• similarity to chronic myelomonocytic leukemia after induction of cre mediated recombination
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immune system
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• striking peripheral blood leukocytosis after induction of cre mediated recombination
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• striking peripheral blood monocytosis after induction of cre mediated recombination
• increase in monocyte numbers in the bone marrow and liver after induction of cre mediated recombination
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• expansion of the red pulp with diffuse infiltration by myeloid and monocytic cells after induction of cre mediated recombination
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• after induction of cre mediated recombination
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• expansion of the red pulp after induction of cre mediated recombination
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growth/size/body
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• after induction of cre mediated recombination
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncstntm1.1Akli mutation
(0 available);
any
Ncstn mutation
(33 available)
Tg(VAV1-cre)1Graf mutation
(1 available)
|
|
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mortality/aging
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• do not survive more than 20 weeks
|
hematopoietic system
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• significant reduction of the lymphoid-biased multipotential progenitor population (L-MPP)
• striking increase in the absolute numbers of both bone marrow and spleen granulocyte/monocyte progenitors cells
• decrease of the megakaryocyte?erythrocyte progenitor population
• progenitor cells display an increase in their self-renewal capacity
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• striking peripheral blood leukocytosis
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• striking peripheral blood monocytosis
• increase in monocyte numbers in the bone marrow and liver
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• de-repression of an extended myeloid-specific program in LSK cells
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• increase in LSK numbers
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• expansion of the red pulp with diffuse infiltration by myeloid and monocytic cells
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• expansion of the red pulp
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neoplasm
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• similarity to chronic myelomonocytic leukemia
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immune system
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• striking peripheral blood leukocytosis
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• striking peripheral blood monocytosis
• increase in monocyte numbers in the bone marrow and liver
|
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• expansion of the red pulp with diffuse infiltration by myeloid and monocytic cells
|
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• expansion of the red pulp
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growth/size/body
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncstntm1.1Akli mutation
(0 available);
any
Ncstn mutation
(33 available)
Tet2tm1.1Iaai mutation
(2 available);
any
Tet2 mutation
(778 available)
Tg(VAV1-cre)1Graf mutation
(1 available)
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mortality/aging
immune system
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• with massive infiltration of differentiated and blast-like myeloid cells
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• increased circulating blast-like cells at 7 weeks after birth
• massive infiltration of differentiated and blast-like myeloid cells in the spleen
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• with an increase in absolute myelomonocytic and blast-like cells 7 weeks after birth
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neoplasm
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• spleen tumor cells transplanted into lethally irradiated recipients induce increased myeloid cell counts in peripheral blood and lethality compared with cells from control mice
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• massive infiltration of differentiated and blast-like myeloid cells in the spleen
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hematopoietic system
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• with massive infiltration of differentiated and blast-like myeloid cells
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• enlarged granulocyte-macrophage progenitor (GMP) compartment
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• increased circulating blast-like cells at 7 weeks after birth
• massive infiltration of differentiated and blast-like myeloid cells in the spleen
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• with an increase in absolute myelomonocytic and blast-like cells 7 weeks after birth
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growth/size/body
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• with massive infiltration of differentiated and blast-like myeloid cells
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