Analysis Tools
mortality/aging
|
• mice die between E16.5 and E18.5
|
cellular
| N |
• mouse embryonic fibroblasts exhibit normal sensitivity to UV or hydroxyurea treatment
|
|
• of mouse embryonic fibroblasts and enhanced by methoxyamine treatment
|
|
• of mouse embryonic fibroblasts
|
|
• of mouse embryonic fibroblasts
|
|
• partially impaired in methylmethanesulfonate- and methoxyamine-treated mouse embryonic fibroblasts
|
respiratory system
absent lungs
(
J:167544
)
|
• complete absence of lungs in all embryos
|
|
• at E11.5 and E12.5, mice lack developing pulmonary epithelium unlike wild-type mice
• however, respiratory endoderm is initially specified normally
|
|
• early arrest in tracheal development
• separation of the trachea from the esophagus stalls early
|
|
• at E12.5, absent in all but one mice
|
growth/size/body
|
• at E15.5, E16.5, and E18.5
|
cardiovascular system
|
• secondary to absence of lungs, mice exhibit a caudal drop of the atrium relative to the ventricle compared to in wild-type mice
|
nervous system
exencephaly
(
J:167544
)
|
• in 25% of mice
|
hematopoietic system
|
• secondary to absence of lungs
|
homeostasis/metabolism
|
• partially impaired in methylmethanesulfonate- and methoxyamine-treated mouse embryonic fibroblasts
|
immune system
|
• secondary to absence of lungs
|
endocrine/exocrine glands
|
• secondary to absence of lungs
|
