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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Smotm2.1Amc
targeted mutation 2.1, Andrew P McMahon
MGI:4834775
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Smotm2Amc/Smotm2.1Amc
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ 		involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J * CBA/J MGI:4843924
cn2
 		Smotm2Amc/Smotm2.1Amc
Nkx2-5tm1(cre)Rjs/Nkx2-5+ 		involves: 129S7/SvEvBrd * 129X1/SvJ MGI:4843927
cn3
 		Smotm2Amc/Smotm2.1Amc
Tg(Mpz-cre)94Imeg/0 		involves: 129X1/SvJ MGI:4843926
cn4
 		Smotm2Amc/Smotm2.1Amc
Tg(Tek-cre)12Flv/0 		involves: 129X1/SvJ * C57BL/6 MGI:4843921
cn5
 		Smotm2Amc/Smotm2.1Amc
Tg(Tnnt2-cre)5Blh/0 		involves: 129X1/SvJ * C57BL/6 * DBA/2 MGI:4843922
cn6
 		Smotm2Amc/Smotm2.1Amc
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		involves: 129X1/SvJ * C57BL/6J * CBA/J MGI:4843923


Genotype
MGI:4843924
cn1
Allelic
Composition		 Smotm2Amc/Smotm2.1Amc
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (10 available); any Gt(ROSA)26Sor mutation (1046 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (25 available)
Smotm2.1Amc mutation (0 available); any Smo mutation (44 available)
Smotm2Amc mutation (2 available); any Smo mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
decreased cardiac neural crest cell number ( J:135134 )
• the number of cardiac neural crest cells reaching the outflow tract is moderately reduced compared to in wild-type mice
impaired cardiac neural crest cell differentiation ( J:135134 )
• mice exhibit abnormal patterning of cardiac neural crest cells compared to in wild-type mice

cardiovascular system
decreased cardiac neural crest cell number ( J:135134 )
• the number of cardiac neural crest cells reaching the outflow tract is moderately reduced compared to in wild-type mice
impaired cardiac neural crest cell differentiation ( J:135134 )
• mice exhibit abnormal patterning of cardiac neural crest cells compared to in wild-type mice

nervous system
decreased cardiac neural crest cell number ( J:135134 )
• the number of cardiac neural crest cells reaching the outflow tract is moderately reduced compared to in wild-type mice
impaired cardiac neural crest cell differentiation ( J:135134 )
• mice exhibit abnormal patterning of cardiac neural crest cells compared to in wild-type mice

cellular
impaired cardiac neural crest cell differentiation ( J:135134 )
• mice exhibit abnormal patterning of cardiac neural crest cells compared to in wild-type mice




Genotype
MGI:4843927
cn2
Allelic
Composition		 Smotm2Amc/Smotm2.1Amc
Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic
Background		 involves: 129S7/SvEvBrd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx2-5tm1(cre)Rjs mutation (1 available); any Nkx2-5 mutation (21 available)
Smotm2.1Amc mutation (0 available); any Smo mutation (44 available)
Smotm2Amc mutation (2 available); any Smo mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal artery morphology ( J:135134 )
• at E10.5 and E18.5, mice exhibit abnormal arch-artery patterning compared to in wild-type mice
abnormal cardiac outflow tract development ( J:135134 )
• at E10.5, mice exhibit short outflow tract compared with wild-type mice
• mice exhibit cell death in the anterior heart field unlike in wild-type mice

embryo
abnormal neural crest cell apoptosis ( J:135134 )
• mice exhibit cell death in neural crest cells unlike in wild-type mice
abnormal neural crest cell migration ( J:135134 )
• mice exhibit abnormal neural crest cells localization and septation defects compared with wild-type mice

cellular
abnormal neural crest cell apoptosis ( J:135134 )
• mice exhibit cell death in neural crest cells unlike in wild-type mice
abnormal neural crest cell migration ( J:135134 )
• mice exhibit abnormal neural crest cells localization and septation defects compared with wild-type mice




Genotype
MGI:4843926
cn3
Allelic
Composition		 Smotm2Amc/Smotm2.1Amc
Tg(Mpz-cre)94Imeg/0
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smotm2.1Amc mutation (0 available); any Smo mutation (44 available)
Smotm2Amc mutation (2 available); any Smo mutation (44 available)
Tg(Mpz-cre)94Imeg mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal cardiovascular development ( J:135134 )
• authors state that mice exhibit identical cardiac defects as observed in Smotm2Amc/Smotm2.1Amc Tg(Wnt1-cre)11Rth mice




Genotype
MGI:4843921
cn4
Allelic
Composition		 Smotm2Amc/Smotm2.1Amc
Tg(Tek-cre)12Flv/0
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smotm2.1Amc mutation (0 available); any Smo mutation (44 available)
Smotm2Amc mutation (2 available); any Smo mutation (44 available)
Tg(Tek-cre)12Flv mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:135134 )
N
• mice exhibit normal outflow tract development




Genotype
MGI:4843922
cn5
Allelic
Composition		 Smotm2Amc/Smotm2.1Amc
Tg(Tnnt2-cre)5Blh/0
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smotm2.1Amc mutation (0 available); any Smo mutation (44 available)
Smotm2Amc mutation (2 available); any Smo mutation (44 available)
Tg(Tnnt2-cre)5Blh mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:135134 )
N
• mice exhibit normal outflow tract development




Genotype
MGI:4843923
cn6
Allelic
Composition		 Smotm2Amc/Smotm2.1Amc
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (25 available)
Smotm2.1Amc mutation (0 available); any Smo mutation (44 available)
Smotm2Amc mutation (2 available); any Smo mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal artery morphology ( J:135134 )
• at E10.5 and E18.5, mice exhibit arch-artery defects compared with wild-type mice
pulmonary artery hypoplasia ( J:135134 )
• in 4 of 23 mice
abnormal cardiac outflow tract development ( J:135134 )
• mice exhibit partial septation of the outflow tract unlike wild-type mice
persistent truncus arteriosus ( J:135134 )
• in 17 of 23 mice
transposition of great arteries ( J:135134 )
• 2 of 23 mice exhibit complete separation of a transposed aorta and hypoplastic pulmonary artery unlike in wild-type mice

embryo
abnormal neural crest cell apoptosis ( J:135134 )
• mice exhibit cell death in neural crest cells unlike in wild-type mice

cellular
abnormal neural crest cell apoptosis ( J:135134 )
• mice exhibit cell death in neural crest cells unlike in wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory