Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll1tm1Mjo mutation
(3 available);
any
Dll1 mutation
(46 available)
Tg(Six2-EGFP/cre)1Amc mutation
(1 available)
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renal/urinary system
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• nephron development is mildly disrupted
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Droshatm1Litt mutation
(1 available);
any
Drosha mutation
(96 available)
Tg(Six2-EGFP/cre)1Amc mutation
(1 available)
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renal/urinary system
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• increased apoptosis of cortical and central mesenchymal and epithelial cells
• normal apoptosis of stromal cells
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• increase in stromal tissue in newborns
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• cystic dilation of renal tubules in newborns
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• no mature glomeruli in E18.5 embryos and in newborns
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• reduced number of glomeruli in E16.5 embryos
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• reduced number of S-shaped bodies in E13.5 embryos with further reduction at E16.5
• immature comma- and S-shaped bodies in E16.5 embryos
• no mature glomeruli in E18.5 embryos and in newborns
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• thin and discontinuous cortical nephrogenic zone
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• smaller kidneys with reduced tubular structures in newborns
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• cystic dilation in newborns
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• at least one absent kidney in 36% of E16.5 embryos, both absent in 6.5%
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mortality/aging
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• early perinatal mortality: no offspring beyond weaning stage
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cellular
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• increased apoptosis of cortical and central mesenchymal and epithelial cells
• normal apoptosis of stromal cells
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behavior/neurological
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• smaller milk spot in newborns
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cardiovascular system
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• causing death within hours of birth
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homeostasis/metabolism
growth/size/body
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• cystic dilation of renal tubules in newborns
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respiratory system
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• causing death within hours of birth
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm2(tetO-LIN28B)Gqda mutation
(1 available);
any
Col1a1 mutation
(160 available)
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy mutation
(5 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Tg(Six2-EGFP/cre)1Amc mutation
(1 available)
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renal/urinary system
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• mice develop cystic kidneys when transgene expression is induced with doxycycline early in embryonic development or in adult mice
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neoplasm
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N |
• mice do not develop renal tumors following doxycycline induction
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growth/size/body
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• mice develop cystic kidneys when transgene expression is induced with doxycycline early in embryonic development or in adult mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(EIF1AX-Lin28a)#Gqda mutation
(0 available)
Tg(Six2-EGFP/cre)1Amc mutation
(1 available)
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renal/urinary system
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• mice develop cystic kidneys
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neoplasm
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N |
• mice do not develop renal tumors
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growth/size/body
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• mice develop cystic kidneys
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1.1(CAG-YFP/DROSHA*E1147K)Gess mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Tg(Six2-EGFP/cre)1Amc mutation
(1 available)
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cellular
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• increased apoptosis of epithelial cells and in nephrogenic zone
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growth/size/body
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• severe growth retardation
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homeostasis/metabolism
renal/urinary system
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• increased apoptosis of epithelial cells and in nephrogenic zone
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• extensive protein deposits in kidney tubules by age P28
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• reduced and patchy Six2, absent Sited1 and early loss of Wt1 expression in E16.5 embryos
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• severely impaired tubular maturation
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• at least one absent kidney in 23% of E16.5 embryos, both absent in 1.8%
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mortality/aging
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N |
• viable; survive from 38 to 283 days
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neoplasm
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N |
• no kidney tumor development in mice up to 283 days old
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jag1tm1Frad mutation
(0 available);
any
Jag1 mutation
(76 available)
Tg(Six2-EGFP/cre)1Amc mutation
(1 available)
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renal/urinary system
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N |
• nephron development appears essentially normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jag1tm1Frad mutation
(0 available);
any
Jag1 mutation
(76 available)
Tg(Six2-EGFP/cre)1Amc mutation
(1 available)
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renal/urinary system
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• nephron number is highly reduced
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll1tm1Mjo mutation
(3 available);
any
Dll1 mutation
(46 available)
Jag1tm1Frad mutation
(0 available);
any
Jag1 mutation
(76 available)
Tg(Six2-EGFP/cre)1Amc mutation
(1 available)
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renal/urinary system
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N |
• nephron development appears essentially normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll1tm1Mjo mutation
(3 available);
any
Dll1 mutation
(46 available)
Jag1tm1Frad mutation
(0 available);
any
Jag1 mutation
(76 available)
Tg(Six2-EGFP/cre)1Amc mutation
(1 available)
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renal/urinary system
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• almost all nephrons are absent
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll1tm1Mjo mutation
(3 available);
any
Dll1 mutation
(46 available)
Jag1tm1Frad mutation
(0 available);
any
Jag1 mutation
(76 available)
Tg(Six2-EGFP/cre)1Amc mutation
(1 available)
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renal/urinary system
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• podocytes are almost entirely absent; one allele of Dll1 cannot support podocyte production
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll1tm1Mjo mutation
(3 available);
any
Dll1 mutation
(46 available)
Jag1tm1Frad mutation
(0 available);
any
Jag1 mutation
(76 available)
Tg(Six2-EGFP/cre)1Amc mutation
(1 available)
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renal/urinary system
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• nephron number is severely compromised, but some podocytes form
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp6ap2tm1.1Aich mutation
(0 available);
any
Atp6ap2 mutation
(9 available)
Tg(Six2-EGFP/cre)1Amc mutation
(1 available)
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mortality/aging
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• mice die within 48 hours of birth
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renal/urinary system
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• kidneys have many cysts in the cortex and outer medulla at P0
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• thin kidney cortex at P0
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• kidneys have many cysts in the cortex and outer medulla at P0
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• decreased nephrogenesis, with premature depletion of the progenitor cell population within the cap mesenchyme
• the cap mesenchyme shows fewer proliferating cells, however apoptosis is no different from controls
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• marker analysis shows reduced inductive and differentiation response within the metanephric mesenchyme
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• kidneys lack a well-defined nephrogenic zone at P0
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• kidneys are reduced in size at E13.5 and in newborns
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• kidney weight is lower in newborns
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• nephron structure volume compared to total kidney volume is reduced at E12.5
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• developing glomeruli volume and average size are reduced at E12.5
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• nascent nephrons reach the renal vesicle stage but do not develop beyond
• kidneys show less developed epithelial structures at E13.5, with embryos having few vesicles and comma-shaped nephron structures
• all stages of nephron development are reduced at P0 and marker analysis shows that nephron induction and specification of proximal nephron segments are impaired at birth
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• the number of S-shaped bodies is reduced at E12.5
• however, renal vesicle number is not different at E12.5
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• the number of comma-shaped bodies is reduced at E12.5
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• decrease in the number of nephrons at P0
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• ureteric bud branching is reduced at E13.5
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growth/size/body
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• kidneys have many cysts in the cortex and outer medulla at P0
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• kidneys have many cysts in the cortex and outer medulla at P0
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp6ap2tm1.1Aich mutation
(0 available);
any
Atp6ap2 mutation
(9 available)
Tg(Six2-EGFP/cre)1Amc mutation
(1 available)
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renal/urinary system
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• increase in urinary albumin excretion
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• focal glomerulosclerosis
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• kidney weight is reduced at 2 months of age
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnnm2tm1Hmik mutation
(0 available);
any
Cnnm2 mutation
(98 available)
Tg(Six2-EGFP/cre)1Amc mutation
(1 available)
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cardiovascular system
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• in untreated animals and in mice subjected to unilateral nephrectomy and deoxycorticosterone acetate (DOCA)-salt treatment
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homeostasis/metabolism
growth/size/body
mortality/aging
Analysis Tools
