Atp6ap2^tm1.1Aich
Targeted Allele Detail

Summary

• Symbol: Atp6ap2^tm1.1Aich
• Name: ATPase, H+ transporting, lysosomal accessory protein 2; targeted mutation 1.1, Atsuhiro Ichihara
• MGI ID: MGI:4836029
• Synonyms: PRR^flox
• Gene: Atp6ap2 Location: ChrX:12454040-12483288 bp, + strand Genetic Position: ChrX, 7.42 cM
• Alliance: Atp6ap2^tm1.1Aich page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:165020
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and was followed by an FRT flanked neomycin and a second loxP site. A third loxP site was placed immedicately downstream of exon 2. Properly targeted mice were bred to mice expressing flp recombinase in order to remove the neomycin selection cassette and leave exon 2 surrounded by loxP sites. (J:165020)

Expression

In Mice Carrying this Mutation:	1 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	18 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atp6ap2 Mutation: 9 strains or lines available

References

• Original: J:165020 Kinouchi K, et al., The (pro)renin receptor/ATP6AP2 is essential for vacuolar H+-ATPase assembly in murine cardiomyocytes. Circ Res. 2010 Jul 9;107(1):30-4
• All: 27 reference(s)