All Phenotypes Tbx18<tm4(cre)Akis> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tbx18^tm4(cre)Akis
targeted mutation 4, Andreas Kispert
MGI:3841145

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Tbx18^tm1Akis/Tbx18^tm4(cre)Akis	involves: 129S1/SvImJ	MGI:5576975
cn2	Hprt1^{tm4(CAG-Tbx18*,-Venus)Akis}/Y Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Tbx18^tm4(cre)Akis/Tbx18⁺	involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * NMRI	MGI:5576973
cn3	Hprt1^{tm4(CAG-Tbx18*,-Venus)Akis}/Y Tbx18^tm4(cre)Akis/Tbx18⁺	involves: 129S1/SvImJ * NMRI	MGI:5576974
cn4	Hprt1^{tm3(CAG-Tbx18,-Venus)Akis}/Y Tbx18^tm4(cre)Akis/Tbx18⁺	involves: 129S1/SvImJ * NMRI	MGI:5576972
cn5	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Tbx18^tm4(cre)Akis/Tbx18⁺ Wt1^tm1Jae/Wt1^tm1Jae	involves: 129S4/SvJae	MGI:3841149
cn6	Hprt1^{tm1(CAG-Sox9,-EGFP)Akis}/Y Tbx18^tm4(cre)Akis/Tbx18⁺	involves: 129/Sv * 129S1/SvImJ * NMRI	MGI:4849535

Allelic Composition	Tbx18^tm1Akis/Tbx18^tm4(cre)Akis
Genetic Background	involves: 129S1/SvImJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx18^tm1Akis mutation (0 available); any Tbx18 mutation (36 available)
Tbx18^tm4(cre)Akis mutation (0 available); any Tbx18 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:210076 )

N	• mice exhibit normal epicardial development at E18.5

Allelic Composition	Hprt1^{tm4(CAG-Tbx18*,-Venus)Akis}/Y Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Tbx18^tm4(cre)Akis/Tbx18⁺
Genetic Background	involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * NMRI

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} mutation (10 available); any Gt(ROSA)26Sor mutation (944 available)
Hprt1^{tm4(CAG-Tbx18*,-Venus)Akis} mutation (0 available); any Hprt1 mutation (1274 available)
Tbx18^tm4(cre)Akis mutation (0 available); any Tbx18 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal epicardium development ( J:210076 )

• epicardial cells exhibit premature smooth muscle cell differentiation and fail to invade into the right ventricular myocardium unlike in wild-type mice

Allelic Composition	Hprt1^{tm4(CAG-Tbx18*,-Venus)Akis}/Y Tbx18^tm4(cre)Akis/Tbx18⁺
Genetic Background	involves: 129S1/SvImJ * NMRI

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1^{tm4(CAG-Tbx18*,-Venus)Akis} mutation (0 available); any Hprt1 mutation (1274 available)
Tbx18^tm4(cre)Akis mutation (0 available); any Tbx18 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:210076 )

• mice die at E14.5

cardiovascular system

cardiovascular system phenotype ( J:210076 )

N	• cardiomyocytes apoptosis and size are normal

abnormal sinus venosus morphology ( J:210076 )

• sinus horn defects

heart hypoplasia ( J:210076 )

thin ventricle myocardium compact layer ( J:210076 )

• beginning at E12.5 and worsening at E14.5

abnormal pericardium morphology ( J:210076 )

decreased fetal cardiomyocyte proliferation ( J:210076 )

• in the right ventricular myocardium at E12.5 and E13.5

cellular

decreased fetal cardiomyocyte proliferation ( J:210076 )

• in the right ventricular myocardium at E12.5 and E13.5

muscle

thin ventricle myocardium compact layer ( J:210076 )

• beginning at E12.5 and worsening at E14.5

decreased fetal cardiomyocyte proliferation ( J:210076 )

• in the right ventricular myocardium at E12.5 and E13.5

Allelic Composition	Hprt1^{tm3(CAG-Tbx18,-Venus)Akis}/Y Tbx18^tm4(cre)Akis/Tbx18⁺
Genetic Background	involves: 129S1/SvImJ * NMRI

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1^{tm3(CAG-Tbx18,-Venus)Akis} mutation (0 available); any Hprt1 mutation (1274 available)
Tbx18^tm4(cre)Akis mutation (0 available); any Tbx18 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:210076 )

• although present in Mendelian ratios at E18.5, mice are not recovered after birth

cardiovascular system

cardiovascular system phenotype ( J:210076 )

N	• heart morphology is normal at E18.5

Allelic Composition	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Tbx18^tm4(cre)Akis/Tbx18⁺ Wt1^tm1Jae/Wt1^tm1Jae
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1Sor mutation (8 available); any Gt(ROSA)26Sor mutation (944 available)
Tbx18^tm4(cre)Akis mutation (0 available); any Tbx18 mutation (36 available)
Wt1^tm1Jae mutation (3 available); any Wt1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal epicardium development ( J:147421 )

• the formation of the epicardium is severely compromised in E12.5 embryos

Allelic Composition	Hprt1^{tm1(CAG-Sox9,-EGFP)Akis}/Y Tbx18^tm4(cre)Akis/Tbx18⁺
Genetic Background	involves: 129/Sv * 129S1/SvImJ * NMRI

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1^{tm1(CAG-Sox9,-EGFP)Akis} mutation (0 available); any Hprt1 mutation (1274 available)
Tbx18^tm4(cre)Akis mutation (0 available); any Tbx18 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

abnormal ureter morphology ( J:166547 )

• mice exhibit excessive deposition of glycosamiglycans/mucopolysaccharides compared with wild-type mice

• the composition of ureter extracellular matrix is altered compared to in wild-type mice

• however, radial patterning of ureteric mesenchyme is normal

abnormal ureter smooth muscle morphology ( J:166547 )

• mice exhibit disorganized smooth muscle layers in the ureters with round smooth muscle cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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