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Tbx18tm1Akis
Targeted Allele Detail
Summary
Symbol: Tbx18tm1Akis
Name: T-box18; targeted mutation 1, Andreas Kispert
MGI ID: MGI:3044914
Synonyms: Tbx18-
Gene: Tbx18  Location: Chr9:87584853-87613313 bp, - strand  Genetic Position: Chr9, 47.06 cM, cytoband E3.2
Alliance: Tbx18tm1Akis page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:90513
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S1/SvImJ
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn IRES-lacZ gene followed by a floxed neo cassette were inserted into the 5'-untranslated region of exon 1 via homologous recombination deleting part of exon 1. Down-regulation and absence of RNA expression was confirmed by in situ hybridization. LacZ expression does not recapitulate endogenous expression. (J:90513)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 15 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tbx18 Mutation:  36 strains or lines available
References
Original:  J:90513 Bussen M, et al., The T-box transcription factor Tbx18 maintains the separation of anterior and posterior somite compartments. Genes Dev. 2004 May 15;18(10):1209-21
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/14/2024
MGI 6.23
The Jackson Laboratory